REG - Coiled Therapeutics - Appointment of Non-Executive Director

Coiled TherapeuticsAnnouncement

07/05/2026 07:00

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RNS Number : 2933D  Coiled Therapeutics PLC  07 May 2026

7 May 2026

Coiled Therapeutics plc

("Coiled Therapeutics" or the "Company")

 

Appointment of Non-Executive Director

Leading oncologist joins the Board

 

Coiled Therapeutics plc (AIM: COIL), the clinical-stage oncology company
developing precision medicines for hard-to-treat cancers, announces the
appointment of Dr Andrew Dean as Non-Executive Director with immediate effect.

 

Dr. Dean brings a wealth of leadership experience from clinical, academic, and
corporate settings. He currently consults for GenesisCare, one of the world's
largest integrated cancer care providers, and serves as the Head of Oncology
at St John of God Subiaco Hospital in Western Australia, which operates the
busiest clinical trials unit of any private hospital in the region. He is
currently overseeing a number of studies into pancreatic, gastrointestinal and
gynaecological cancers.  Under his leadership, the hospital was awarded the
most outstanding site award by the Australasian GastroIntestinal Trials Group.

 

In addition to his clinical leadership, Dr. Dean serves as a board member for
Valo Therapeutics, a clinical stage immunotherapy company that develops novel
treatments for cancer and infectious diseases, and was the founder of the
award-winning health information site, virtualmedicalcentre.com.

 

His extensive research background, which includes the molecular profiling of
solid tumours and novel therapies for ovarian cancer, provides direct,
relevant expertise that aligns with Coiled Therapeutics' precision oncology
focus and its lead candidate, AO-252.

 

Commenting on the appointment, Sotirios Stergiopoulos, Chairman of Coiled
Therapeutics, said: "We are delighted to welcome Andrew to the Board of Coiled
Therapeutics. His vast experience as a clinical investigator and his deep
expertise in the development of novel cancer therapies will be of considerable
value as we advance our lead asset, AO-252.  Andrew's guidance will be
invaluable as we progress through late-stage clinical studies and work to
bring our transformative treatments to patients in need."

 

Andrew Dean, Non-Executive Director, added: "I am excited to be joining Coiled
Therapeutics as a Non-Executive Director at such a pivotal moment in the
Company's development. The recent clinical data for AO-252 is highly
promising, demonstrating a significant clinical benefit and durable responses
in a heavily pre-treated patient population. I am impressed by the innovative
science behind the Company's TACC3 inhibitor and its unique immune-modulatory
potential. I look forward to working with the Board and management team to
help guide this promising technology through the next stages of development."

 

The following disclosures are made pursuant to Schedule 2(g) of the AIM Rules
for Companies:

Dr Andrew Peter Dean, aged 63, currently holds or has held the following
directorships or partnerships in the past five years:

 

 Current                          Past five years
 Valo Therapeutics OY

 Valo Therapeutics Italy S.R.L.

 

Dr Andrew Dean currently holds 1,963,605 ordinary shares representing 0.46% of
the Company's issued share capital and holds no options or warrants over the
Company's ordinary shares.

There are no further disclosures required in accordance with AIM Rule 17 or
Schedule 2(g) of the AIM Rules for Companies.

Enquiries:

 Coiled Therapeutics plc

 Sotirios Stergiopoulos (Chairman)                                          Via Burson Buchanan

 Sridhar Vempati (CEO)

 SP Angel Corporate Finance LLP (Nominated Adviser and Joint Broker)  +44 (0)20 3470 0470

 David Hignell / Adam Cowl / Devik Mehta (Corporate Finance)

 Vadim Alexandre / Rob Rees (Corporate Broking)

 Shard Capital Partners LLP (Joint Broker)                            +44 (0)20 4530 6926

 Damon Heath

 CPS Capital Group Pty Ltd (Joint Broker)                             +61 (0)8 9223 2222

 Jason Peterson / David Valentino

 Burson Buchanan (Public Relations)                                   +44 (0)20 7466 5000

 Henry Harrison Topham / Jamie Hooper / Toto Berger

 

 

About Coiled Therapeutics plc

Coiled Therapeutics (AIM: COIL) is an AIM-listed, clinical-stage biotechnology
company focused on developing innovative precision oncology therapies. Its
lead programme, AO-252, is a novel TACC3 inhibitor currently in Phase I
clinical trials in the USA (trials ID: NCT06136884).  Coiled Therapeutics is
actively enrolling patients to test for safety and efficacy in patients whose
cancer has progressed on other treatments.   The Company is also assessing
its STAT-6 siRNA programme for immunology indications. Coiled Therapeutics is
supported by a leadership team with a proven track record in drug development
and strategic backing from A2A Pharmaceuticals.

 

About AO-252

AO-252 is a first-in-class, orally administered, brain-penetrant small
molecule inhibitor of Transforming Acidic Coiled-Coil containing protein 3
(TACC3). TACC3 is a validated oncology target that is frequently overexpressed
in many aggressive, hard-to-treat solid tumours but is dispensable in normal
adult cells, providing a wide therapeutic window.

 

By selectively disrupting cancer-critical protein-protein interactions at the
TACC3 C-terminal domain, AO-252 induces mitotic and replication stress,
impairs DNA damage repair, and triggers cancer cell death. Notably, AO-252 has
demonstrated the ability to cross the blood-brain barrier, addressing a
significant unmet medical need for the treatment of brain metastases.

 

The asset is currently in an ongoing Phase I open-label dose-escalation study
and early clinical signals have shown encouraging anti-tumour activity and a
benign safety profile, with the Company planning to initiate dose expansion
cohorts in lead indications, including prostate and ovarian cancer, during
2026.

 

For more information, please visit: www.coiledplc.com
(http://www.coiledplc.com/)

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