Xilio Therapeutics posts Q4 profit on higher collaboration revenue

Xilio Therapeutics

23/03/2026 11:38

Overview

US biotechnology firm's Q4 net income turned positive, driven by higher collaboration and license revenue

Operating expenses for Q4 increased year-over-year due to expanded R&D and clinical activities

Company extended cash runway through end of 2027

Outlook

Xilio expects to submit an IND for XTX501 in mid-2026 and start Phase 1 in H2 2026

Company anticipates nominating a masked T cell engager candidate targeting PSMA and STEAP1 in Q2 2026

Xilio expects its cash and equivalents to fund operations through end of 2027

Result Drivers

COLLABORATION REVENUE - Co said higher collaboration and license revenue was mainly due to agreements and milestone payments with AbbVie and Gilead

R&D EXPANSION - Co attributed higher R&D expenses to manufacturing for IND-enabling studies, preclinical development for XTX501, clinical activities for efarindodekin alfa, and masked T cell engager programs

WARRANT EXERCISES & MILESTONE PAYMENTS - Co said cash position improved due to warrant exercises and milestone payments under collaborations

Company press release: ID:nGNXbKpj0f

Key Details

Metric
Beat/Miss
Actual
Consensus Estimate
Q4 Net Income
$10.36 mln
Q4 Income from Operations
-$11.84 mln
Q4 Operating Expenses
$25.52 mln


Analyst Coverage

The one available analyst rating on the shares is "strong buy"

The average consensus recommendation for the biotechnology & medical research peer group is "buy."

Wall Street's median 12-month price target for Xilio Therapeutics Inc is $28.00, about 256.2% above its March 20 closing price of $7.86

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(This story was created using Reuters automation and AI based on LSEG and company data. It was checked and edited by a Reuters journalist prior to publication.)