** Shares of drug developer Zynerba Pharmaceuticals ZYNE.O
rise over four-fold to $1.37 premarket
** Drugmaker Harmony Biosciences Holdings HRMY.O says it
will acquire ZYNE for $1.11 per share
** Deal gives HRMY access to ZYNE's lead candidate being
developed for Fragile X syndrome
** Fragile X syndrome is a genetic condition that causes a
range of developmental problems, including learning disabilities
and cognitive impairment
** The drug candidate, zygel, is a cannabidiol-based gel
formulation being developed to treat FXS as well as 22q deletion
syndrome, a disorder caused by the deletion of a small piece of
chromosome 22 - HRMY
** Under the deal, ZYNE is eligible to receive up to $140
mln in milestone payments - HRMY
** Up to last close, ZYNE down 36% YTD
(Reporting by Mariam Sunny in Bengaluru)
((Mariam.ESunny@thomsonreuters.com;))