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REG - Aptamer Group PLC - Fundraise to Raise £2.83 million

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RNS Number : 6877X  Aptamer Group PLC  24 July 2024

THIS ANNOUNCEMENT (THE "ANNOUNCEMENT") AND THE INFORMATION CONTAINED IN IT, IS
NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, DIRECTLY OR
INDIRECTLY, IN OR INTO THE UNITED STATES OF AMERICA, ITS TERRITORIES AND
POSSESSIONS, ANY STATE OF THE UNITED STATES OR THE DISTRICT OF COLUMBIA
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AFRICA OR JAPAN OR ANY OTHER JURISDICTION IN WHICH SUCH PUBLICATION, RELEASE
OR DISTRIBUTION WOULD BE UNLAWFUL.

FURTHER, THIS ANNOUNCEMENT IS FOR INFORMATION PURPOSES ONLY AND IS NOT AN
OFFER OF SECURITIES IN ANY JURISDICTION.

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION.

24 July 2024

 

Aptamer Group plc

 

("Aptamer Group", "APTA" or the "Company")

 

Firm Placing, Conditional Placing and Subscription to Raise £2.83 million

Grant of Share Options

Proposed Board Changes

Related Party Transaction

Notice of General Meeting

Aptamer Group (AIM:APTA), the developer of novel Optimer® binders to enable
innovation in the life sciences industry, is pleased to announce that it has
conditionally raised £2.83 million (before expenses),  by way of a placing
and subscription (the "Fundraise") of 1,415,000,000 New Ordinary Shares at an
issue price of 0.2p per share (the "Issue Price") for working capital
purposes.

The Fundraise comprises:

·    a firm placing of 116,835,918 New Ordinary Shares (the "Firm Placing
Shares") at the Issue Price, which is not conditional on Shareholder approval
to raise approximately £0.2 million (before expenses) (the "Firm Placing");
and

 

·    a conditional placing of 1,272,164,082 New Ordinary Shares (the
"Conditional Placing Shares") at the Issue Price to raise approximately £2.5
million (before expenses) (the "Conditional Placing Shares") and a conditional
subscription for 26,000,000 New Ordinary Shares (the "Subscription Shares") to
raise £0.1 million (before expenses), each of which will require Shareholder
approval at the General Meeting.

 

The Issue Price represents a discount of approximately 63.6 per cent. to the
closing price per Ordinary Share of 0.55 pence at close of business on 23 July
2024, being the last practicable date prior to the announcement of the
Fundraise. The New Ordinary Shares will represent approximately 75.3 per cent.
of the Enlarged Issued Share Capital.

 

First Admission of the Firm Placing Shares is expected to become effective and
dealings are expected to commence at 8.00 a.m. on 29 July 2024.

Subject to the passing of the Resolutions at the General Meeting, Second
Admission of the Conditional Placing Shares and the Subscription Shares is
expected to become effective and dealings are expected to commence at 8.00
a.m. on 14 August 2024.

SPARK Advisory Partners Limited has acted as Nominated and Financial Adviser
and Turner Pope Investments (TPI) Ltd has acted as Bookrunner in relation to
the Fundraise.

Background and Reasons for the Fundraise

The Company aims to maximise the potential of its Optimer(®) binder
technology in applications across the life sciences and other industries. The
Company is a recognised global player in aptamer technology, a technology that
the Company believes can make significant inroads into the annual
c.$171billion affinity ligand market. The business model aims to deliver both
recurring fee-for-service revenue for the development of Optimer binders and
higher-value licensing revenue that could contribute significant incremental
revenues through upfront, milestones and royalty payments.

A shortfall in fee-for-service revenue in the year ended 30 June 2023 resulted
in pressure on working capital and a resultant lull in customer confidence.
This necessitated a fundraise in August 2023, the proceeds of which were used
to alleviate working capital pressure and focus on rebuilding customer
confidence and the Company's fee-for-service pipeline. This has taken time,
with expected revenue of only £0.85 million for the year ended 30 June 2024.
The Company has made good progress in rebuilding the fee-for-service pipeline
and in the final quarter of the year ended 30 June 2024 alone has reported
contract wins totalling £0.98 million.

The Company has built and extended commercial relationships which now cover
all of the top 10 pharmaceutical companies globally and many smaller life
sciences companies. This diversified customer base allows the Company to
horizon scan and pursue the most exciting opportunities for aptamer technology
with the ultimate aim to deliver higher value licensing revenue. The Company
has made strong technical progress in the year ended 30 June 2024, developing
several potentially higher value assets, from which it aims to ultimately
deliver material revenues in the form of upfront, milestone and royalty
payments.

Strategy

The Company's strategy remains to develop fee-for-service revenues to a point
at which they are generating positive net cashflow and to use the connections
and opportunities which those fee-for-service projects bring to develop and
licence material assets.  The Directors believe that these licensing
opportunities are capable of delivering higher long-term value compared to
ongoing fee-for-service work. As a result of market interest in Aptamer's
technology, reflected in the Board's success in revitalising the sales
pipeline over the past year, the Directors believe the Company's strategic
assets are now primed for licensing over the coming years, representing the
best potential value for shareholders.

Aptamer has cultivated several potentially high-value assets across its
business units, which will be further developed in collaboration with partners
with the aim of reaching licensing agreements if successful.

 

Within Aptamer Therapeutics, Optimer delivery vehicles targeting cells
associated with fibrotic liver disease have been developed through a project
with a top 15 pharmaceutical company. After demonstrating efficacy in gene
therapy delivery (in lab based testing), the Optimer is now being evaluated by
this partner, with a potential for future licensing. Interest has also been
received from other top 10 pharmaceutical and biotechnology companies.
Licensing deals in this space typically reach double-digit millions, with
potential total values exceeding £1 billion once the technology reaches
preclinical testing. The fibrotic liver Optimer has now advanced through the
drug development stage and needs preclinical evidence of its efficacy to
achieve comparable deal values for the Optimer platform as a whole and this
asset in particular. Based on the results generated with this asset, a new
agreement has been established with AstraZeneca to support exploration of the
potential of the Optimer platform to generate delivery vehicles for siRNA,
using AstraZeneca's siRNA payload.

Within Aptamer Solutions, Aptamer successfully developed an Optimer with the
potential to treat malodour, as part of a fee-for-service project with
Unilever. Assessment of the binder at Aptamer Group and Unilever has shown
good results in lab-based tests, indicative of their potential use in cosmetic
applications and treatment of malodour. The project is ongoing in Unilever's
labs, with the intention to progress to on-person functionality tests in 2024.
Based on standard cosmetic development pathways, this project is anticipated
to conclude within 2 years and, if successful, could lead to a licensing
agreement with Unilever.

Within Aptamer Diagnostics, Optimers have been developed to a novel
Alzheimer's disease biomarker to enable a rapid diagnostic as part of a
fee-for-service project with Neuro-Bio. Following the successful development
of the first Optimer, Neuro-Bio has commissioned the development of a second
Optimer to support a fully animal-free test. Negotiations are underway for the
potential downstream use of the Optimers with high single digit royalties for
Aptamer proposed across the sale of these tests. The Optimer and Optimer+
platforms will continue to provide binder development services under a
fee-for-service model for clients across the life sciences sector. The Board
believes that this approach will sustain Aptamer's overall revenue and serve
as a horizon-scanning platform that identifies high-value assets for future
development and licensing opportunities.

To achieve EBITDA break-even on fee-for-service revenue alone, Aptamer is
committed to rigorous cost management. The Company aims to reduce its fixed
cost base from approximately £3.5 million to around £2.9 million in the
coming financial year. This will be achieved through planned reductions in the
senior leadership team and office space commitments. Importantly, these cost
reductions will not compromise operational capacity or the scientific
expertise within the Group, ensuring the necessary know-how for continued
technical and commercial advancement. The revitalised fee-for-service
pipeline, now converting a higher proportion of opportunities, along with a
lower cost base, will make achieving EBITDA break-even more attainable for
Aptamer.

Key strategic milestones for the development of Optimer assets include
licensing the Optimer critical reagent and conducting on-person functionality
studies for the malodour Optimer in FY25. Additionally, Aptamer aims to
complete the project with Unilever, potentially leading to licensing, and to
deliver a rapid diagnostic for Alzheimer's disease with Neuro-Bio by FY26.

To further advance Aptamer Group's objectives, where funds permit, the company
will advance the evaluation and optimisation of the Optimer+ platform and
progress the Optimer delivery vehicles for fibrotic liver disease to secure a
committed development partner.

Board changes

In connection with the Fundraise, the following Board changes are proposed.
The following changes are conditional on and will take effect immediately
upon, Second Admission:

·    Stephen Hull (Executive Chairman) and Dean Fielding (Non-Executive
Director) will step down from the Board and leave the Company.

·    Dr Adam Hargreaves will become Non-Executive Chairman.

·    Dr Arron Tolley the current Chief Technical Officer will become Chief
Executive Officer.

·    Andrew Rapson the current Chief Financial Officer will be appointed
to the Board.

Accordingly, the directors following completion of the Fundraise will be Dr
Adam Hargreaves, Dr Arron Tolley, Dr David Bunka, and Andrew Rapson. Further
details of the Proposed Director are set out at paragraph 3 below.

The Board is actively seeking to recruit an independent Non-Executive Director
and hopes to fill this vacancy in the near term.

Share Options

The Company intends to award share options to retain and incentivise the
Directors and employees.  The number of share options granted will be up to
25 per cent. of the issued share capital as enlarged by the Fundraise.  These
options will vest subject to stretching performance targets and will vest and
exercise as follows:

(a)     33% on the share price having remained at or above 7 times the
Issue Price for at least 3 months and exercisable 6 months following vesting;

(b)     33% on the share price having remained at or above 10 times the
Issue Price for at least 3 months and exercisable 12 months following vesting;
and

(c)     33% on the share price having remained at or above 12.5 times the
Issue Price for at least 3 months and exercisable 24 months following vesting.

All in the money share options would vest in the event that the Company is
acquired (or in the event of that a person or group shall have acquired or
entered into a definitive binding agreement to acquire more than 50% of the
issued share capital of the Company or assets of the Company or its
subsidiaries representing more than 50% of the consolidated earning power of
the Company and its subsidiaries taken as a whole).

The options will have an exercise price equal to the Issue Price.

The award of these options will be a related party transaction under the AIM
Rules and will therefore be subject to the independent directors considering
the terms of the options and reaching an opinion, having consulted with SPARK,
as its nominated adviser, that the terms of the transaction are fair and
reasonable insofar as its shareholders are concerned. It is currently
envisaged that these options will be awarded following the Second Admission.

In October 2023 share options were awarded to Directors and staff with an
exercise price of 1 penny. Awardees of that option scheme will forfeit their
share options on acceptance of this latest award.

Details of the Proposed Director

Andrew Rapson - Chief Financial Officer (aged 42 years)

Andrew Rapson is a qualified chartered accountant with an accountancy career
spanning over 20 years. He has worked in an AIM environment for the last 9
years, formerly as Head of Finance for Hunters Property plc before joining
Aptamer Group plc in 2022.

Use of Proceeds

The Company intends to use £2.0 million of the net proceeds of the Fundraise
for working capital purposes, covering a two-year period in which the Company
will focus on bringing licence opportunities to fruition and continuing to
grow the fee-for-service business.

The Company intends to use the surplus funds raised in excess of £2.0 million
for research and development purposes. This includes supporting high value
projects through to commercial milestones, namely the fibrotic liver drug
delivery and Optimer+.

Current Trading and Outlook

On 8 July 2024, the Company provided a trading update, as follows:

 

Upturn in sales and order book as the year progressed

The unaudited revenue for the year was approximately £0.85 million with
£0.55 million generated in the second half of the year. Following the lull in
customer confidence caused by the acute funding problem in August 2023,
confidence had to be rebuilt with customers which translated into the
rebuilding of the sales pipeline. These efforts have led to increased revenues
in the second half of the year and an encouraging rise in order book values.
In the last quarter of the financial year, £0.98 million in orders were won
which has resulted in a total of £1.8 million in signed orders currently
being processed or awaiting processing in the laboratory.

In addition to the order book, we have a current pipeline of advanced sales
negotiations totalling £2.1 million. Consequently, Aptamer Group is
well-positioned moving into the new financial year, with ongoing work
progressing through the lab and a robust sales pipeline.

Strong technical delivery across strategic assets

Over the year, Aptamer Group has made significant technical progress on the
advancement of key Optimer assets:

·    Optimer binders for Immunohistochemistry (IHC) are continuing to be
evaluated by a top-five pharmaceutical company with the potential for
licensing. The partner has demonstrated Optimer performance in IHC assays
within its own laboratories and is expanding testing to new application areas.

·    In partnership with Neuro-Bio, Aptamer Group is advancing the second
phase of Optimer development for a rapid diagnostic test for early Alzheimer's
disease. Negotiations for downstream royalties, if successful, are under
discussion.

·    Following submission of a patent application in March for Optimer
binders that are intended for the treatment of malodour, this work is
continuing in Unilever's labs, with on-person functionality studies planned
for the second half of 2024. This project is anticipated to complete over the
next two years, and if successful, could result in Aptamer licensing the
Optimer binders to Unilever.

·    Optimer-based delivery vehicles for precision medicines are being
developed for fibrotic liver disease and are undergoing evaluation with a top
15 pharma partner. Based on the Company's internal data the partner requested
Aptamer manufacture test amounts of Optimer-siRNA conjugates for evaluation in
their own laboratories, with the potential for licensing if successful. These
data have generated substantial interest from several pharmaceutical and
biotechnology companies, including AstraZeneca where we are also developing
data using their siRNA for their internal evaluation.

 

The demonstration of the Optimer technology across a range of strategic assets
exemplifies the Company's focus on developing high-value solutions, which can
be licenced to partners for downstream revenue.

Steve Hull, Executive Chair of Aptamer Group, said: "The trajectory of both
sales and revenue shows increasing potential, putting Aptamer Group on a good
footing for the forthcoming year. The team has worked hard to rebuild the
pipeline in the past year, and it is pleasing to see we have achieved a
continued increase in sales throughout the year, with £0.98 million sales
orders signed in the final quarter alone showing this work is beginning to pay
off for the Company. We have made excellent technical progress this year
having focussed on key strategic assets. Successful work is ongoing with
Unilever to deliver Optimers aimed for use in personal care products, and we
have had high interest from multiple top pharma companies in our Optimer
delivery vehicles for fibrotic liver disease. As we continue to progress these
projects with our partners, the Company increases its potential to generate
significant licensing revenue from these high-value assets."

Risk Factors

In addition to the risk factors set out in the Company's AIM Admission
Document dated 16 December 2021 and the section headed "principal risks and
uncertainties" in the Company's annual report and accounts for the financial
year ended 30 June 2023, which should be considered carefully in evaluating
whether to make an investment in the Company, the Directors note the
following:

Loss making and early-stage of revenue generation

Aptamer Group is at an early stage of its development and faces a number of
operational, strategic and financial risks frequently encountered by companies
looking to bring new products to the market. Aptamer Group has not yet
reported a profit and there can be no assurance that it will do so.

The Group currently has not generated a net positive operating cash flow and
its ultimate success will depend on the Board's ability to implement the
Group's strategy and generate positive cash flow. Whilst the Board is
optimistic about the Group's prospects, there is no certainty that anticipated
outcomes and sustainable revenue streams will be achieved. There can be no
assurance that the Group's proposed operations will be cash generative or
produce a reasonable return, if any, on any investment.

In particular, its future growth and prospects will depend on its ability:

·          to develop, source or acquire products which have
commercial appeal;

·          to secure commercialisation partnerships with contract
manufacturers on appropriate terms;

·          to secure commercialisation partnerships with contract
sales organisations on appropriate terms;

·          to manage the growth of the business; and

·          to continue to expand and improve operational, financial
and management information, quality control systems and its commercialisation
function on a timely basis whilst at the same time maintaining effective cost
controls.

Any one or more of these risks could have a material adverse effect on the
Group's business, financial condition and results of operations.

New ventures and/or partnerships with third parties may not be successful

The Group has entered into a number of collaborative ventures with third
parties. It may also in the future enter into further ventures, partnerships
or other collaborative arrangements with these existing and/or other third
parties. There is a risk that such ventures, partnerships or other
collaborative arrangements may not be commercially successful. It is possible
that the working relationship between the parties may break down, that
substantial costs and/or liabilities may be incurred in attempting to deliver
the product or service in question, and/or that the venture, partnership or
other arrangement may not yield the returns expected.

There is a risk that parties with which the Group has business relationships,
including its partners and those with which it collaborates, may become
insolvent or may otherwise become unable or unwilling to fulfil their
obligations as part of the arrangement. This could detrimentally affect
projects upon which the parties are collaborating and could adversely affect
the Group's ability to deliver the products or services in question, which may
in turn have a negative impact upon its business, financial position and
prospects. It may also result in the Group having to input further capital
into the project in order to ensure that delivery of the project remains
unaffected. This extra cost could in turn adversely affect the business,
revenues and profitability of the Group.

The Group may experience delays which could lead to detrimental outcomes for
development projects

Both Aptamer Group and its target customers operate in complex scientific
areas where individual projects or new technology developments can take months
or years to complete. Accordingly, delays in a customer's or target customer's
development schedule or changing strategic priorities could cause a delay in
the development of a new product or technology for reasons beyond Aptamer
Group's control. Such delays could have an adverse impact on the Group's
business, financial condition and results of operations.

Additional financing

The Group expects to incur significant costs in connection with development,
commercialisation and intellectual property protection of its technology. The
Group's working capital requirements depend on numerous factors, including the
rate of market acceptance of its services, its ability to attract customers
and other factors that may be outside of the Group's control. The Group may
require additional financing in the medium to long term, whether from equity
or debt sources, to finance working capital requirements or to finance its
growth through future stages of development.

Any additional share issue may have a dilutive effect on Shareholders,
particularly if they are unable to, or choose not to, subscribe by taking
advantage of rights of pre-emption that may be available. Debt funding may
require the lender to take security over the assets of the Group, which may be
exercised if the Group were to be unable to comply with the terms of the
relevant debt facility agreement. Failure to obtain adequate future financing
on acceptable terms, if at all, could cause the Group to delay, reduce or
abandon its development programmes or hinder commercialisation of its product
portfolio and could have a material adverse effect on the Group's business,
financial condition or operating results.

Investment in AIM securities and liquidity of the Group's Ordinary Shares

An investment in companies whose shares are traded on AIM is perceived to
involve a higher degree of risk and be less liquid than an investment in
companies whose shares are listed on the Official List. AIM is a market
designed primarily for emerging or smaller companies. The rules of this market
are less demanding than the Official List. The future success of AIM and
liquidity in the market for Ordinary Shares cannot be guaranteed. In
particular, the market for Ordinary Shares may become or may be relatively
illiquid and therefore, such Ordinary Shares may be or may become difficult to
sell.

The market for the Ordinary Shares following First Admission and Second
Admission (as applicable) may be highly volatile and subject to wide
fluctuations in response to a variety of factors which could lead to losses
for Shareholders. These potential factors include amongst others: any
additions or departures of key personnel, litigation and press, newspaper
and/or other media reports.

Prospective investors should be aware that the value of the Ordinary Shares
may go down as well as up, that the market price of the Ordinary Shares may go
down as well as up and that the market price of the Ordinary Shares may not
reflect the underlying value of the Group. Investors may, therefore, realise
less than or lose all of their investment.

VCT/EIS status

The status of the VCT/EIS Shares as a qualifying holding for VCT purposes or
as "eligible shares" for EIS purposes is conditional, amongst other things,
upon the Company and its trade satisfying the requirements of VCT/EIS (as
applicable) throughout the period the New Ordinary Shares are held as a
qualifying holding for VCT and/or EIS purposes and on the investor that is
seeking to avail itself of VCT qualifying status, or the reliefs available
under EIS, satisfying certain conditions.

Neither the Directors nor the Company give any warranty or undertaking that:
(i) VCT qualifying status is or will be available; (ii) New Ordinary Shares
will be "eligible shares" for the purposes of Part 5 of the Income Tax Act
2007; or (iii) that the Company will conduct its activities in a way that
qualifies for or preserves its status or the status of any investment in New
Ordinary Shares.

If the law regarding the reliefs available to investors in VCTs and/or EIS
change, any qualifying status previously obtained (if any) may be lost or
withdrawn.

Investors considering taking advantage of any of the reliefs available to VCTs
or under EIS should seek their own professional advice in order that they may
fully understand how the rules apply in their individual circumstances and
what they are required to do in order to claim any reliefs (if available). As
the rules governing VCT and EIS reliefs are complex and interrelated with
other legislation, if any potential investors are in any doubt as to their tax
position, require more detailed information than the general outline above, or
are subject to tax in a jurisdiction other than the UK, they should consult
their professional advisers.

Details of the Fundraise

The Company has conditionally raised a total of £2.83 million (before
expenses) through the Firm Placing, the Conditional Placing and the
Subscription.

The Company intends to issue up to 1,415,000,000 New Ordinary Shares pursuant
to the Fundraise, representing in aggregate, approximately 74.9 per cent. of
the Enlarged Share Capital, comprising:

·          a total of 116,835,918 New Ordinary Shares placed by
Turner Pope pursuant to the Firm Placing as agent of the Company at the Issue
Price, raising gross proceeds of approximately £0.2 million (before
expenses);

·          a total of 1,272,164,082 New Ordinary Shares
conditionally placed by Turner Pope pursuant to the Conditional Placing as
agent of the Company at the Issue Price, raising gross proceeds of
approximately £2.5 million (before expenses); and

·          a total of 26,000,000 New Ordinary Shares conditionally
subscribed for by the Subscriber at the Issue Price pursuant to the
Subscription, raising gross proceeds of £0.1 million (before expenses).

The Company proposes to issue the New Ordinary Shares to be issued pursuant to
the Fundraise at the Issue Price, which represents a 63.6 per cent. discount
to the closing mid-price of 0.55 pence on 23 July 2024, being the last
practicable dealing date prior to the date of the Company's announcement of
the Fundraise.

Certain of the Directors and the Proposed Director have agreed to participate
in the Fundraise by participating in the Placing in aggregate in the amount of
£80,000 (further details are set out below).

The Firm Placing, the Conditional Placing and the Subscription are not being
underwritten.

Details of the Firm Placing

Pursuant to the Firm Placing, the Company has raised approximately £0.2
million (before expenses). The Firm Placing is not conditional on the
Resolutions being passed at the General Meeting with the Firm Placing Shares
being issued pursuant to the Company's existing share allotment authorities
obtained at the last annual general meeting of the Company.

The Firm Placing Shares, when issued and fully paid, will rank pari passu in
all respects with the Existing Ordinary Shares.

 New Ordinary Shares have been allotted and issued pursuant to the Firm
Placing.  Application has been made for the Firm Placing Shares to be
admitted to trading on AIM ("First Admission"). First Admission is expected to
occur at 8.00 a.m. on or around 29 July 2024.

Details of the Conditional Placing and the Subscription

Conditional Placing

The Company has conditionally raised a total of approximately £2.5 million
(before expenses) through the Conditional Placing and the Subscription.

The Conditional Placing and the Subscription are conditional, inter alia,
upon:

(a)           the issue of the Firm Placing Shares and First
Admission occurring by no later than 31 July 2024 (or such later time and/or
date as the Company, Turner Pope and SPARK may agree;

(b)           the passing of the Resolutions at the General Meeting
(or any adjournment thereof) by not later than 31 August 2024;

(c)           the Placing Agreement becoming unconditional in all
respects (other than in respect of Admission) and not having been terminated
in accordance with its terms;

(d)           the Company not being in breach of any of its
obligations and undertakings under the Placing Agreement which fall to be
performed prior to First Admission or Second Admission, save for any breach
which is not, in the opinion of Turner Pope and SPARK (acting in good faith)
material in the context of the Placing; and

(e)           Second Admission occurring by not later than 8.00 a.m.
on 14 August 2024 (or such later time and/or date as the Company, Turner Pope
and SPARK may agree, not being later than 8.00 a.m. on 31 August 2024).

If any of the conditions to the Conditional Placing or the Subscription are
not satisfied or waived (where capable of waiver), the Conditional Placing and
the Subscription will not proceed, the New Ordinary Shares will not be issued
pursuant to the Conditional Placing and the Subscription and any monies
received by Turner Pope or the Company in connection with the Conditional
Placing and the Subscription (as the case may be) will be returned to the
applicants (at the applicants' risk and without interest) as soon as possible
thereafter.

The conditional placing of the Conditional Placing Shares at the Issue Price
has raised approximately £2.5 million (before expenses).

The Conditional Placing Shares, when issued and fully paid, will rank pari
passu in all respects with the Existing Ordinary Shares.

Details of the Subscription

The Subscribers have agreed to subscribe for, in aggregate, 26,000,000 New
Ordinary Shares pursuant to the Subscription direct with the Company.

The Subscription Shares will be issued at the Issue Price, raising £0.1
million for the Company. The Subscribers who have subscribed pursuant to the
Subscription have subscribed directly with the Company for the Subscription
Shares.

The Subscription Shares, when issued and fully paid, will rank pari passu in
all respects with the Existing Ordinary Shares.

The Subscription Shares have been subscribed for conditional upon, inter alia:

(f)            the passing of the Resolutions at the General
Meeting (or any adjournment thereof) by not later than 31 August 2024;

(g)           the Placing Agreement becoming unconditional in all
respects (other than in respect of Second Admission) and not having been
terminated in accordance with its terms; and

(h)           Second Admission occurring by not later than 8.00 a.m.
on 14 August 2024 (or such later time and/or date as the Company, Turner Pope
and SPARK may agree, not being later than 8.00 a.m. on 31 August 2024).

It is expected that the Subscription Shares will be admitted to trading on AIM
at the same time as Second Admission, that is 8.00 a.m. on 14 August 2024 (or
such later time and/or date as the Company, SPARK and Turner Pope may agree
(being no later than 8.00 a.m. on 31 August 2024).

EIS and VCT Status

The Company has been advised that a subscription for New Ordinary Shares by a
VCT should be capable of being a 'qualifying holding' for VCT relief. Although
qualifying investors should obtain tax relief on their investments under EIS
relief or VCT relief, neither the Company, the Directors nor the Proposed
Director can provide any warranty or guarantee in this regard. Investors must
take their own advice and rely on it.

None of the Directors, the Proposed Director nor the Company give any warranty
or undertaking that a subscription for VCT/EIS Shares: (i) is a qualifying
holding for the purposes of Part 6 of the Income Tax Act 2007, or that such
qualifying status will not be withdrawn; or (ii) would be regarded as
"eligible shares" for the purposes of Part 5 of the Income Tax Act 2007, nor
do they warrant or undertake that the Company will conduct its activities in a
way that qualifies for or preserves its status or the status of any investment
in New Ordinary Shares. If the Company carries on activities beyond those
disclosed to HM Revenue & Customs, then shareholders may cease to qualify
for the relevant tax benefits.

Investors considering taking advantage of any of the reliefs available to VCTs
or under EIS should seek their own professional advice in order that they may
fully understand how the rules apply in their individual circumstances and
what they are required to do in order to claim any reliefs (if available). As
the rules governing VCT and/or EIS reliefs are complex and interrelated with
other legislation, if any potential investors are in any doubt as to their tax
position, require more detailed information than the general outline above or
as set out in paragraph 6 (Risk Factors) of this document, or are subject to
tax in a jurisdiction other than the UK, they should consult own their
professional advisers.

Details of the Directors and Proposed Director participating in the Placing

The following Directors and the Proposed Director have agreed to participate
in the Conditional Placing on equivalent terms and conditions and at the same
Issue Price as other participants in the Conditional Placing:

 Director            Number of shares in the Conditional Placing  Amount    Total Number of Shares upon Second Admission  Percentage of issued share capital upon Second Admission
 Dr David Bunka      5,000,000                                    £10,000   18,524,200                                    0.98%
 Dr Arron Tolley     5,000,000                                    £10,000   21,794,200                                    1.15%
 Dr Adam Hargreaves  27,500,000                                   £55,000   50,000,000                                    2.65%
 Proposed Director
 Andrew Rapson       2,500,000                                    £5,000    3,000,000                                     0.16%

 

Placing Agreement

Pursuant to the terms of the Placing Agreement, Turner Pope, as agent for the
Company, conditionally agreed to use its reasonable endeavours to procure
subscribers for the Placing Shares at the Issue Price. The Placing Agreement
is conditional, amongst other things, on none of the warranties given to
Turner Pope and SPARK being or becoming untrue, inaccurate or misleading in
any respects on or before Second Admission.

Under the Placing Agreement, the Company has agreed to pay to Turner Pope a
fixed sum and/or commissions based on the aggregate value of the Placing, and
the costs and expenses incurred in relation to the Placing, and to grant
138,900,000 Broker Warrants to Turner Pope.

The Placing Agreement contains customary warranties given by the Company in
favour of Turner Pope and SPARK in relation to, amongst other things, the
accuracy of the information in the Circular and other matters relating to the
Group and its business. In addition, the Company has agreed to indemnify
Turner Pope and SPARK (and their respective affiliates) in relation to certain
liabilities which they may incur in respect of the Fundraise.

Turner Pope and SPARK have the right to terminate the Placing Agreement in
certain circumstances prior to First Admission or Second Admission (as
applicable), in particular, in the event of breach of the warranties, the
occurrence of a material adverse change or if the Placing Agreement does not
become unconditional.

Rights of the New Ordinary Shares

The New Ordinary Shares will, when issued, be credited as fully paid and will
be issued subject to the Articles and rank pari passu in all respects with the
Existing Ordinary Shares, including the right to receive all dividends and
other distributions declared, made or paid on or in respect of the Ordinary
Shares after the date of issue of the New Ordinary Shares and will, on issue,
be free of all claims, liens, charges and encumbrances.

Director Fee Shares

In connection with the Fundraise, and conditional on Second Admission, Stephen
Hull will step down from the Board and leave the Company. Under the terms of
his appointment, Stephen Hull is entitled to three months' notice of
termination of his appointment. In line with the Company's strategy of cash
preservation and cost saving, it has been agreed that instead of paying
Stephen Hull £20,000 by way of payment of fees in lieu of notice, Stephen
Hull will receive 8,000,000 Ordinary Shares (the "Director Fee Shares") at the
Issue Price in settlement of the fees due to him and the Company will apply
the amount owed to him by the Company in paying up the Director Fee Shares.
The Director Fee Shares will, when issued be credited as fully paid and will
rank pari passu in all respects with the existing Ordinary Shares, including
the right to receive all dividends or other distributions made, paid or
declared in respect of such shares after the date of issue.

 

Broker Warrants

Under the terms of the Placing Agreement, 138,900,000 Broker Warrants will be
issued to JIM Nominees Limited (as nominee on behalf of Turner Pope) as part
consideration payable to Turner Pope for its services as placing agent to the
Placing. The Broker Warrants, which are constituted by the Broker Warrant
Instrument, will be exercisable at an exercise price equal to the Issue Price
per Ordinary Share at any time up to the date five years following Second
Admission. No application is being made for the Broker Warrants to trading on
AIM. The Broker warrants are transferable and any transfers must be registered
with the Company. The Broker Warrant Instrument may be amended by the sanction
of an extraordinary resolution (as such term is defined in the Broker Warrant
Instrument) of the holders of the Broker Warrants and with the consent in
writing of the Company.

In August 2023, and as described in the Company's shareholder circular dated
31 July 2023, the Company issued 36,000,000 broker warrants (the "2023 Broker
Warrants") to JIM Nominees Limited (as nominee on behalf of Turner Pope) on
the terms of a warrant instrument dated 31 July 2023 (the "2023 Broker Warrant
Instrument") as part consideration payable to Turner Pope for its services as
placing agent to the placing undertaken at that time. The 2023 Broker Warrants
had a subscription price of 1 pence per ordinary share. The terms of the 2023
Warrant Instrument may be amended by the sanction of an extraordinary
resolution (as such term is defined in the 2023 Warrant Instrument) of the
holders of the 2023 Broker Warrants and with the consent in writing of the
Company.

In connection with the Fundraise, and as part consideration payable to Turner
Pope for its services as placing agent to the Firm Placing and the Conditional
Placing, the Company has agreed conditional on Second Admission and subject to
the sanction of an extraordinary resolution of the holders of the 2023 Broker
Warrants (being Turner Pope) to amend the subscription price for the 2023
Broker Warrants so that the subscription price is equal to the Issue Price.

Admission, Settlement and Dealings

The New Ordinary Shares will be issued credited as fully paid and will rank
pari passu with the Existing Ordinary Shares, including the right to receive
all dividends and other distributions declared, made or paid in respect of
Ordinary Shares after First Admission or Second Admission (as applicable).

An application will be made to the London Stock Exchange for the Firm Placing
Shares to be admitted to trading on AIM.

It is expected that First Admission will occur and dealings on AIM will
commence in the Firm Placing Shares at 8.00 a.m. on or around 29 July 2024 (or
such later time and/or date as Turner Pope and SPARK may agree with the
Company, being not later than 8.00 a.m. on 31 August 2024).

It is expected that CREST accounts of the investors in the Firm Placing Shares
who hold their Ordinary Shares in CREST will be credited with their New
Ordinary Shares on 29 July 2024.

In the case of investors in the Firm Placing Shares holding their Ordinary
Shares in certificated form, it is expected that certificates will be
dispatched the week commencing 29 July 2024. Pending dispatch of the share
certificates or the crediting of CREST accounts, the registrar will certify
any instruments of transfer against the register.

It is expected that Second Admission will occur and dealings on AIM will
commence in the Conditional Placing Shares, the Subscription Shares and the
Director Fee Shares subject, inter alia, to the passing of the Resolutions at
the General Meeting at 8.00 a.m. on or around 13 August 2024 (or such later
time and/or date as Turner Pope and SPARK may agree with the Company, being
not later than 8.00 a.m. on 31 August 2024).

It is expected that CREST accounts of the investors in the Conditional Placing
Shares and the Subscription Shares who hold their Ordinary Shares in CREST
will be credited with their New Ordinary Shares on 14 August 2024.

In the case of investors in the Conditional Placing Shares holding their
Ordinary Shares in certificated form, it is expected that certificates will be
dispatched during the week commencing 19 August 2024. Pending dispatch of the
share certificates or the crediting of CREST accounts, the registrar will
certify any instruments of transfer against the register.

Related Party Transaction

The participation of Dr Adam Hargreaves, Dr David Bunka, Dr Arron Tolley and
Andrew Rapson in the Conditional Placing is regarded as a related party
transaction under the AIM Rules. They are participating on the same terms as
all other investors. The issue of the Director Fee Shares to Stephen Hull is
also considered a related party transaction under the AIM Rules.

The independent director, being Dean Fielding, considers, having consulted
with SPARK as the Company's nominated adviser, that the terms of the
transaction are fair and reasonable insofar as shareholders are concerned.

General Meeting

The Directors do not currently have sufficient authority to allot in full the
Conditional Placing Shares pursuant to the Conditional Placing, the
Subscription Shares pursuant to the Subscription, the Director Fee Shares or
the Broker Warrants. Accordingly, the Board is seeking the approval of
Shareholders of the following at the General Meeting: (i) to allot the
Conditional Placing Shares pursuant to the Conditional Placing, the
Subscription Shares pursuant to the Subscription and to issue the Director Fee
Shares and the Broker Warrants, (ii) to award shares pursuant to any
Director's (including non-executive director) or employees' share option
scheme, plan or share option agreement, and to disapply pre-emption rights in
respect of the same, and (iii) to allot shares and to disapply pre-emption
rights to replace the existing authorities passed at the Company's annual
general meeting on 15 December 2023 which are being utilised to issue and
allot the Firm Placing Shares.

In addition, the Directors are seeking shareholder approval to amend the terms
of the 2023 Broker Warrant Instrument to amend the subscription price

At the General Meeting, the following resolutions will be proposed:

·    Resolution 1 (subject to Resolution 2, Resolution 4 and Resolution 5
being passed): which is an ordinary resolution to authorise the Directors to:
(a) allot equity securities (as defined in section 560 of the Act) up to a
maximum aggregate nominal amount of £1,445,064.082 pursuant to the
Conditional Placing and the Subscription, (b) issue the Director Fee Shares,
and (c) issue the Broker Warrants;

 

·    Resolution 2 (subject to Resolution 1, Resolution 4 and Resolution 5
being passed): which is an ordinary resolution to authorise the Directors to
award shares up to a maximum aggregate nominal amount of £472,585.92 pursuant
to terms of any Director's (including a non-executive director) or employees'
share option scheme, plan or share option agreement as detailed in paragraph 2
of Part I of this document;

 

·    Resolution 3 (subject to Resolution 6 being passed): which is an
ordinary resolution to authorise the Directors to allot equity securities (as
defined in section 560 of the Act) up to a maximum aggregate nominal amount of
£629,484.44 (being approximately 33.3 per cent. of the Enlarged Share
Capital) and £1,258,968.88 in relation to a rights issue only (being
approximately 66.6 per cent. of the Enlarged Share Capital to replace the
authorities granted at the Company's annual general meeting dated 15 December
2023 (which will be used to issue and allot the Firm Placing Shares), and to
expire on conclusion of the annual general meeting of the Company to be held
in 2024 or, if earlier, at the close of business on 31 December 2024;

 

·    Resolution 4 (subject to Resolution 1, Resolution 2 and Resolution 5
being passed): which is a special resolution to authorise the Directors to:
(a) issue and allot equity securities (as defined in section 560 of the Act)
on a non-pre-emptive basis up to a maximum aggregate nominal amount of
£1,445,064.082 pursuant to the Conditional Placing and Subscription, (b)
issue the Director Fee Shares and (c) issue the Broker Warrants;

 

·    Resolution 5 (subject to Resolution 1, Resolution 2 and Resolution 4
being passed): which is a special resolution to authorise Directors to award
shares pursuant to terms of any Director's (including a non-executive
director) or employees' share option scheme, plan or share option agreement as
detailed in paragraph 2 of the Circular on a non-pre-emptive basis up to a
maximum aggregate nominal amount of £472,585.92, to expire at the close of
business on the date which is five years after the passing of the resolution;
and

 

·    Resolution 6 (subject to Resolution 3 being passed); which is a
special resolution to allot equity securities on a non pre-emptive basis up to
a maximum aggregate nominal amount of £283,551.55 (being approximately 15 per
cent. of the Enlarged Share Capital) pursuant to Resolution 3, and to expire
on conclusion of the annual general meeting of the Company to be held in 2024
or, if earlier, at the close of business on 31 December 2024. This resolution
will replace the authority granted at the Company's annual general meeting
dated 15 December 2023 (which will be used to issue and allot the Firm Placing
Shares).

 

Resolutions 1, 2 and 3 will be proposed as ordinary resolutions. For an
ordinary resolution to be passed, more than half of the votes cast must be in
favour of the resolution.

Resolutions 4, 5 and 6 will be proposed as special resolutions. For a special
resolution to be passed, at least three quarters of the votes cast must be in
favour of the resolution.

Resolution 3 is intended to replace Resolution 10 passed at the annual general
meeting of the Company held on 15 December 2023 but without prejudice to any
allotment of shares or grant of rights already made, offered or agreed to be
made pursuant to such authority.

Following the issue of the Firm Placing Shares, Resolution 6 is intended to
refresh Resolution 11 passed at the annual general meeting of the Company held
on 15 December 2023.

There are no present plans to undertake a rights issue or to allot new shares
pursuant to Resolution 3 and 6. The Directors consider it desirable to have
the maximum flexibility permitted to respond to market and business
developments.

In accordance with section 571(6) of the Act, the Board refers to its
recommendation to Shareholders set out paragraph 15 of this Part I to cast
their votes in favour of the Resolutions, to the quantum of the Fundraise
(which the Board considers to be a prudent balance between the Company's
current and planned financial requirements and not wishing unduly to dilute
the interests of Shareholders) and the proposed application of the net
proceeds of the Fundraise as further described in paragraph 4 of Part I of
this document.

Shareholders are reminded that the Conditional Placing and the Subscription is
conditional, amongst other things, on the passing of the Resolutions to be
proposed at the General Meeting.

Further information on the Resolutions to be proposed at the General Meeting
will be set out in the Circular.

Irrevocable Undertakings

The Company has received irrevocable undertakings to vote in favour of the
Resolutions from each of the Directors who hold Ordinary Shares in respect of
in aggregate 56,982,200 Ordinary Shares representing 12.19 per cent. of the
issued share capital as at the date of this announcement.

Total Voting Rights

 

Immediately following First Admission, the Company will have 584,179,591
ordinary shares of £0.001 each in issue.

 

Immediately following Second Admission the Company will have 1,890,343,673
ordinary shares of £0.001 each in issue.

 

The Company does not hold any shares in treasury and all of the Ordinary
Shares have equal voting rights. Therefore, the figures above represent the
total voting rights in the Company and may be used by shareholders as the
denominator for the calculations by which they can determine if they are
required to notify their interest in, or a change to their interest in the
Company under the Rules.

 

- ENDS -

 

For further information, please contact:

 

 Aptamer Group plc                                        +44 (0) 1904 217 404

 Dr Arron Tolley
 SPARK Advisory Partners Limited - Nominated Adviser      +44 (0) 20 3368 3550

 Andrew Emmott / Adam Dawes
 Turner Pope Investments (TPI) Ltd - Broker               +44 (0) 20 3657 0050

 James Pope / Andrew Thacker

 

Unless otherwise indicated, capitalised terms in this announcement have the
meaning given to them in this announcement (including the definitions section
included in the Appendix).

This announcement contains inside information for the purposes of Article 7 of
Regulation (EU) No 596/2014 as it forms part of UK domestic law by virtue of
the European Union (Withdrawal) Act 2018.

About Aptamer Group plc

Aptamer Group develops custom affinity binders through its proprietary
Optimer® platform to enable new approaches in therapeutics, diagnostics,
and research applications. The Company strives to deliver transformational
solutions that meet the needs of life science researchers and developers.

Optimer binders are oligonucleotide affinity ligands that can function as an
antibody alternative. The global affinity ligand market is currently worth
over $170 billion.

Aptamer has successfully delivered projects for a range of global pharma
companies, diagnostic development companies, and research institutes, covering
multiple application areas with the objective of establishing royalty-bearing
licenses.

Important Notices

Neither this announcement, nor any copy of it may be made or transmitted into
the United States of America (including its territories or possessions, any
state of the United States of America and the District of Columbia) (the
"United States"). Neither this announcement nor any copy of it may be taken or
transmitted directly or indirectly into Australia, Canada, the Republic of
South Africa, New Zealand, Japan or to any persons in any of those
jurisdictions, except in compliance with applicable securities laws. Any
failure to comply with this restriction may constitute a violation of United
States, Australian, Canadian, South African, New Zealand or Japanese
securities laws or the securities laws of any other jurisdiction (other than
the United Kingdom). The distribution of this announcement in other
jurisdictions may also be restricted by law and persons into whose possession
this announcement comes should inform themselves about, and observe, any such
restrictions. Any failure to comply with these restrictions may constitute a
violation of the securities laws of any such jurisdiction.

This announcement does not constitute or form part of any offer or invitation
to sell or issue, or a solicitation of any offer to acquire, purchase or
subscribe for, securities of the Company.

The New Ordinary Shares have not been, nor will be, registered under the US
Securities Act of 1933, as amended (the "US Securities Act") or the securities
laws of any state or jurisdiction of the United States, and may not be offered
or sold within the United States to, or for the account or benefit of, US
person (as that term is defined in Regulation S under the US Securities Act),
except pursuant to an exemption from, or in a transaction not subject to, the
registration requirements of the US Securities Act and such other applicable
state securities laws. Accordingly, the New Ordinary Shares are being offered
hereby only outside the United States in reliance upon Regulation S under the
US Securities Act in offshore transactions.

No representation or warranty, express or implied, is made by the Company,
SPARK or Turner Pope as to any of the contents of this announcement, including
its accuracy, completeness or for any other statement made or purported to be
made by it or on behalf of it, the Company, the Directors or any other person,
in connection with the Placing, the Subscription, First Admission and Second
Admission, and nothing in this announcement shall be relied upon as a promise
or representation in this respect, whether as to the past or the future
(without limiting the statutory rights of any person to whom this announcement
is issued).

Forward-Looking Statements

Certain statements contained in this announcement constitute "forward-looking
statements" with respect to the financial condition, performance, strategic
initiatives, objectives, results of operations and business of the Company.

All statements other than statements of historical facts included in this
announcement are, or may be deemed to be, forward-looking statements. Without
limitation, any statements preceded or followed by or that include the words
''targets'', ''plans'', ''believes'', ''expects'', ''aims'', ''intends'',
''anticipates'', ''estimates'', ''projects'', ''will'', ''may'', "would",
"could" or "should", or words or terms of similar substance or the negative
thereof, are forward-looking statements. Forward-looking statements may
include statements relating to the following: (i) future capital expenditures,
expenses, revenues, earnings, cashflows, synergies, economic performance,
indebtedness, financial condition, dividend policy and future prospects; and
(ii) business and management strategies and the expansion and growth of the
Company's operations. Such forward-looking statements involve risks and
uncertainties that could significantly affect expected results and are based
on certain key assumptions, some of which are outside of the Company's
influence and/or control.

Many factors could cause actual results, performance or achievements to differ
materially from those projected or implied in any forward-looking statements.
The important factors that could cause the Company's actual results,
performance or achievements to differ materially from those in the
forward-looking statements include, amongst others, economic and business
cycles, competition in the Company's principal markets, acquisitions or
disposals of businesses or assets, changes in government and other regulation,
changes in political and economic stability and trends in the Company's
principal industries. Due to such uncertainties and risks, undue reliance
should not be placed on such forward-looking statements, which speak only as
of the date of this announcement.

In light of these risks, uncertainties and assumptions, the events described
in the forward-looking statements in this announcement may not occur. No
statement in this announcement is intended to be a profit estimate or profit
forecast. The forward-looking statements contained in this announcement speak
only as of the date of this announcement. Neither the Company nor its
Directors nor any person acting on its or their behalf expressly disclaim any
obligation or undertaking to update or revise publicly any forward-looking
statements, whether as a result of new information, future events or
otherwise, unless required to do so by applicable law or regulation.

Expected Timetable of Key Events

                                                                                All dates 2024
 Date of this document                                                          24 July
 Publication and posting of this document                                       24 July
 First Admission of the Firm Placing Shares to trading on AIM and commencement  on or around 8.00 a.m. on 29 July
 in dealings
 CREST accounts credited in respect of Firm Placing Shares held in              29 July
 uncertificated form
 Despatch of definitive share certificates for Firm Placing Shares held in      Within 10 business days of
 certificated form
29 July
 Latest time and date for receipt of Forms of Proxy                             11.00 a.m. on 9 August
 Latest time and date for receipt of CREST proxy instructions and CREST voting  11.00 a.m. on 9 August
 instructions or casting of proxy vote online or electronically or via
 Proxymity
 Voting Record Time                                                             6.00 p.m. on 9 August
 General Meeting                                                                11.00 a.m. on 13 August
 Announcement of results of General Meeting                                     13 August
 Second Admission and commencement of dealings in the Conditional Placing       on or around 8.00 a.m. on 14 August
 Shares, the Subscription Shares and the Director Fee Shares
 CREST accounts credited in respect of the Conditional Placing Shares and the   14 August
 Subscription Shares
 Despatch of definitive share certificates for applicable Conditional Placing   Within 10 business days of
 Shares and the Subscription Shares
14 August

Notes:

(a)          If any of the details contained in the timetable above
should change, the revised times and dates will be notified to Shareholders by
means of an announcement through a Regulatory Information Service.

(b)          All references to time and dates in this document are to
time and dates in London.

(c)           Certain of the events in the above timetable are
conditional upon, amongst other things, the approval of the Resolutions to be
proposed at the General Meeting.

 

Key Statistics

 Number of Existing Ordinary Shares                                        467,343,673
 Number of New Ordinary shares issued pursuant to the Firm Placing         116,835,918
 Number of New Ordinary shares issued pursuant to the Conditional Placing  1,272,164,082

 Number of Subscription Shares                                             26,000,000
 Number of Director Fee Shares                                             8,000,000
 Total Number of New Ordinary Shares                                       up to 1,423,000,000
 Aggregate number of Broker Warrants                                       138,900,000
 Issue Price                                                               0.2 pence
 Percentage of the Enlarged Share Capital represented by the New Ordinary  75.3 per cent.
 Shares
 Gross proceeds of the Firm Placing                                        £0.2 million
 Gross proceeds of the Conditional Placing                                 £2.5 million
 Gross proceeds of the Subscription                                        £0.1 million
 Gross proceeds of the Fundraise                                           up to £2.83 million
 Estimated net proceeds of the Fundraise                                   up to £2.50 million
 Enlarged Share Capital(1) immediately following Second Admission          1,890,343,673

 

Notes:

(1)  This number assumes that all the Firm Placing Shares are allotted and
issued at First Admission and all the Conditional Placing Shares, Subscription
Shares and Director Fee Shares are allotted and issued at Second Admission.
This calculation also assumes that no further Ordinary Shares are issued under
the Company's share schemes or existing issued warrants (or otherwise) between
the date of this document and Second Admission.

(2)  All references in this document to "pounds sterling", "sterling", "£",
"pence" or "p" are to the lawful currency of the United Kingdom.

 

DEFINITIONS

 "Act"                                     the Companies Act 2006 (as amended);
 "AIM"                                     the market of that name operated by the London Stock Exchange;
 "AIM Rules"                               the AIM Rules for Companies, as published and amended from time to time by the
                                           London Stock Exchange;
 "AIM Rules for Nominated Advisers"        the AIM Rules for Nominated Advisers published by the London Stock Exchange as
                                           amended from time to time;
 "Articles"                                the Company's articles of association;
 "Board" or "Directors"                    the directors of the Company as at the date of this document, whose names are
                                           set out on page 6 of this document;
 "Broker Warrant Instrument"               the warrant instrument dated 24 July 2024 and executed by the Company under
                                           which the Broker Warrants will be issued to JIM Nominees Limited (as nominee
                                           on behalf of Turner Pope);
 "Broker Warrants"                         the 138,900,000 unlisted warrants to be issued to JIM Nominees Limited (as
                                           nominee on behalf of Turner Pope) to subscribe for up to 138,900,000 new
                                           Ordinary Shares, equivalent to 10 per cent. of the aggregate number of Placing
                                           Shares exercisable at the Issue Price for a five year period from Admission,
                                           as constituted by the Broker Warrant Instrument, further details of which can
                                           be found in paragraph 9 of Part I of this document;
 "Business Day"                            any day (excluding Saturdays and Sundays) on which banks are open in London
                                           for normal banking business and the London Stock Exchange is open for trading;
 "certificated" or "in certificated form"  where an Ordinary Share is not in uncertificated form (i.e.  not in CREST);
 "Circular" or "document"                  this circular, dated 24 July 2024;
 "Company" or "Aptamer"                    Aptamer Group plc, a public limited company registered in England and Wales
                                           with company number 09061413 and having its registered office at Windmill
                                           House, Innovation Way, York, England, YO10 5BR;
 "Conditional Placing"                     the proposed placing of the Conditional Placing Shares at the Issue Price on a
                                           non-pre-emptive basis, on the terms and conditions set out in the Placing
                                           Agreement;
 "Conditional Placing Shares"              1,272,164,082 Ordinary Shares to be allotted and issued to new and existing
                                           institutional and other investors by the Company, pursuant to the Conditional
                                           Placing;
 "CREST"                                   the relevant system for the paperless settlement of trades and the holding of
                                           uncertificated securities operated by Euroclear in accordance with the CREST
                                           Regulations;
 "CREST Manual"                            the CREST Manual referred to in agreements entered into by Euroclear and
                                           available at www.euroclear.com;
 "CREST member"                            a person who has been admitted to CREST as a system-member (as defined in the
                                           CREST Regulations);
 "CREST member account ID"                 the identification code or number attached to a member account in CREST;
 "CREST participant"                       a person who is, in relation to CREST, a system-participant (as defined in the
                                           CREST Regulations);
 "CREST participant ID"                    shall have the meaning given in the CREST Manual;
 "CREST payment"                           shall have the meaning given in the CREST Manual;
 "CREST Regulations"                       the Uncertificated Securities Regulations 2001 (SI 2001/3755) including any
                                           enactment or subordinate legislation which amends or supersedes those
                                           regulations and any applicable rules made under those regulations or any such
                                           enactment or subordinate legislation for the time being in force;
 "CREST sponsor"                           a CREST participant admitted to CREST as a CREST sponsor;
 "CREST sponsored member"                  a CREST member admitted to CREST as a CREST sponsored member;
 "Director Fee Shares"                     the 8,000,000 New Ordinary Shares to be awarded to Stephen Hull at the Issue
                                           Price as settlement of directors' fees of £20,000;
 "EIS"                                     Enterprise Investment Scheme (as such term is used in part 5 of the Income Tax
                                           Act 2007);
 "Enlarged Share Capital"                  the entire issued share capital of the Company on Second Admission following
                                           completion of the Fundraise;
 "Euroclear"                               Euroclear UK & International Limited, the operator of CREST;
 "Excluded Jurisdiction"                   the United States, Canada, Australia, Japan, New Zealand or the Republic of
                                           South Africa and any other jurisdictions where the offer, sale, distribution,
                                           take-up or transfer of the New Ordinary Shares, as applicable, would
                                           constitute a breach of local securities laws or regulations;
 "Existing Ordinary Shares"                the 467,343,673 Ordinary Shares in issue at the date of this document;
 "FCA"                                     the Financial Conduct Authority of the United Kingdom;
 "First Admission"                         the admission of the Firm Placing Shares to trading on AIM becoming effective
                                           in accordance with the AIM Rules;
 "Firm Placing"                            the placing of the Firm Placing Shares at the Issue Price on a non-pre-emptive
                                           basis, on the terms and conditions set out in the Placing Agreement;
 "Firm Placing Shares"                     116,835,918 New Ordinary Shares to be issued to new and existing institutional
                                           and other investors in connection with the Firm Placing;
 "Form of Proxy"                           the form of proxy for use by Shareholders in relation to the General Meeting,
                                           a hard copy of which can be requested from the Company's registrar Link Group
                                           in accordance with the instructions set out in this document;
 "FSMA"                                    the Financial Services and Markets Act 2000 (as amended);
 "Fundraise"                               the Placing and the Subscription;
 "General Meeting"                         the General Meeting of the Company convened for 11.00 a.m. on 13 August 2024
                                           or any adjournment thereof, notice of which is set out at the end of this
                                           document;
 "Group"                                   the Company and its subsidiaries (as defined in the Act);
 "Issue Price"                             0.2 pence per New Ordinary Share;
 "London Stock Exchange"                   London Stock Exchange plc;
 "New Ordinary Shares"                     the Firm Placing Shares, the Conditional Placing Shares, the Subscription
                                           Shares and the Director Fee Shares;
 "Notice of General Meeting"               the notice convening the General Meeting as set out at the end of this
                                           document;
 "Official List"                           the Official List of the FCA;
 "Ordinary Shares"                         the ordinary shares of 0.1 pence each in the capital of the Company in issue
                                           from time to time;
 "Placing"                                 the Firm Placing and the Conditional Placing;
 "Placing Agreement"                       the conditional placing agreement entered into between the Company, Turner
                                           Pope and SPARK in respect of the Placing, dated 24 July 2024, as described in
                                           this document;
 "Placing Shares"                          the 1,389,000,000 New Ordinary Shares to be issued pursuant to the Firm
                                           Placing and the Conditional Placing;
 "Prospectus Regulation"                   Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14
                                           June 2017 (which forms part of UK domestic law pursuant to the European Union
                                           (Withdrawal) Act 2018) on the requirements for a prospectus to be published
                                           when securities are offered to the public or admitted to trading;
 "Prospectus Regulation Rules"             the prospectus regulation rules of the FCA made under section 73A of FSMA;
 "Proposed Director"                       Andrew Rapson;
 "Regulatory Information Service"          the meaning given to it in the AIM Rules;
 "Resolutions"                             the resolutions to be proposed at the General Meeting, the full text of which
                                           are set out in the Notice of General Meeting;
 "Second Admission"                        the admission of the Conditional Placing Shares, the Subscription Shares and
                                           the Director Fee Shares to trading on AIM becoming effective in accordance
                                           with the AIM Rules;
 "Securities Act"                          US Securities Act of 1933 (as amended);
 "Shareholders"                            the holders of Existing Ordinary Shares, and the term "Shareholder" shall be
                                           construed accordingly;
 "SPARK"                                   SPARK Advisory Partners Limited, a private limited company incorporated in
                                           England and Wales under company number 03191370 and having its registered
                                           office at 5 St. John's Lane, London, EC1M 4BH, the Company's nominated adviser
                                           in accordance with the AIM Rules;
 "stock account"                           an account within a member account in CREST to which a holding of a particular
                                           share or other security in CREST is credited;
 "Subscribers"                             subscribers who have agreed to participate in the Subscription and subscribe
                                           for the Subscription Shares on the terms of the Subscription Agreements;
 "Subscription"                            the conditional subscription proposed to be made at the Issue Price by the
                                           Subscribers;
 "Subscription Agreements"                 the subscription agreements entered into between the Company and the
                                           Subscriber pursuant to which the Subscribers will agree to subscribe for the
                                           Subscription Shares;
 "Subscription Shares"                     the 26,000,000 New Ordinary Shares proposed to be issued at the Issue Price,
                                           pursuant to the Subscription;
 "Turner Pope"                             Turner Pope Investments (TPI) Ltd, a private limited company incorporated in
                                           England and Wales under company number 09506196 and having its registered
                                           office at 29a Crown Street, Brentwood, England, CM14 4BA, the Company's
                                           appointed placing agent for the Placing;
 "uncertificated" or                       recorded on the relevant register or other record of the share or other

"uncertificated form"                    security concerned as being held in uncertificated form in CREST, and title to
                                           which, by virtue of the CREST Regulations, may be transferred by means of
                                           CREST;
 "United Kingdom" or "UK"                  the United Kingdom of Great Britain and Northern Ireland;
 "VCT"                                     a venture capital trust under part 6 of the Income Tax Act 2007;
 "VCT / EIS Shares"                        such number of Placing Shares and / or Subscription Shares to be allotted and
                                           issued to certain VCTs or to certain persons seeking to invest in "eligible
                                           shares" for the purposes of the EIS;
 "VWAP"                                    volume weighted average price; and
 "£" or "Pounds"                           UK pounds sterling, being the lawful currency of the United Kingdom.

 

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