Factbox: Widely used drugs on US imports list from Europe

Bavarian Nordic A/S

18/03/2025 16:58

March 18 (Reuters) - Widely used prescription medicines could get caught up in the Trump administration's tariff trade wars and EU retaliation.

The following is a list of major prescription drugs whose ingredients or components are imported into the United States from the European Union, based on U.S. Food and Drug Administration import data from 2023 and 2024.

Company
Brand Name (chemical name)
Used to Treat
Country of Import
Company Comments
AbbVie ABBV.N
Rinvoq (upadacitinib)
rheumatoid arthritis
Germany, Ireland
Abbvie declined to comment on specific production or import sites for its drugs. The company said it "maintains a robust, diversified and redundant manufacturing network with geographic balance and multiple supply sites"
Norvir (ritonavir)
HIV
Germany
Humira (adalimumab)
rheumatoid arthritis, psoriatic arthiritis, others
Germany
Amgen AMGN.O
Blincyto (blinatumomab)
A type of acute lymphoblastic leukemia
Netherlands
Prolia/Xgeva (denosumab)
osteoporosis, preventing fractures from cancer in bones
Netherlands
Bavarian Nordic A/S BAVA.CO
Jynneos
smallpox vaccine, also used for mpox
Denmark
Bavarian Nordic said it manufactures all its bulk vaccine/bulk drug substance for Jynneos in Denmark, and the fill and finish is done either at its own site in Denmark or in the U.S., depending on the markets served.
Bristol Myers Squibb BMY.N
Eliquis (apixaban)
Blood thinner/clot preventer
Ireland
Opdivo (nivolumab)
cancer immunotherapy
Ireland
Eli Lilly LLY.N
Mounjaro, Zepbound (tirzepatide)
type 2 diabetes, obesity
Germany, Netherlands
A Lilly spokesperson said the company prefers to source materials internally, as evidenced by its most recent manufacturing announcements. It does not disclose details of in-house vs external manufacturing
Johnson & Johnson JNJ.N
Stelara (ustekinumab)
inflammatory bowel disease, psoriatic arthritis, other autoimmune conditions
Ireland, Netherlands
Invega/Invega Sustenna (paliperidone)
schizophrenia
Ireland
Merck & Co MRK.N
ritonavir
antiviral
Netherlands
Keytruda (pembrolizumab)
cancer immunotherapy
Netherlands, Ireland
Gardasil
HPV vaccine for cancer prevention
Ireland
Novavax NVAX.O
Nuvaxovid
COVID-19 vaccine
Germany
Novavax said its vaccine is manufactured by The Serum Institute in India.
Novo Nordisk NOVOb.CO
Ozempic (semaglutide )
type 2 diabetes,
Ireland, Germany, Denmark
Novo said in a statement that it manufactures the active ingredients for its obesity and diabetes drugs in Denmark and United States only
Wegovy (semaglutide)
obesity
Ireland, Germany
Pfizer PFE.N
Prevnar family
pneumococcal vaccines for pneumonia prevention
Ireland
Penbraya
meningococcal meningitis vaccine
Ireland
Comirnaty
COVID-19 vaccine
Ireland, Germany
Eliquis (apixaban)
blood thinner/clot preventer
Netherlands
Regeneron REGN.O
Eylea (aflibercept )
Wet age-related macular degeneration, other eye conditions
Ireland
Regeneron has manufacturing facilities in both the U.S. and Ireland and is currently expanding its campus in New York.
Roche ROG.S
Avastin (bevacizumab)
metastatic colorectal cancer, diabetic eye disease and other eye disorders
Germany
Roche declined to comment on which drug is produced where, and for which market. It said that a majority of its products cross different countries/continents across the development and supply chain.

 (Reporting by Christy Santhosh, Puyaan Singh and Bhanvi Satija in Bengaluru and Maggie Fick in London; Editing by Michele Gershberg and Bill Berkrot)

 ((Christy.Santhosh@thomsonreuters.com;))