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REG - BioPharma Credit PLC - FINAL RESULTS FOR THE YEAR ENDED 31 DECEMBER 2023

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RNS Number : 4476I  BioPharma Credit PLC  27 March 2024

27 March 2024

BIOPHARMA CREDIT PLC

("BPCR" or "the Company")

FINAL RESULTS FOR THE YEAR ENDED 31 DECEMBER 2023

BioPharma Credit PLC (LSE: BPCR), the specialist life sciences debt investor,
is pleased to present its Final Results for the period ended 31 December 2023.

The full Annual Report and Financial Statements can be accessed via the
Company's website at www.bpcruk.com (http://www.bpcruk.com) or by contacting
the Company Secretary by telephone on 01392 477500.

INVESTMENT HIGHLIGHTS

·    Over the course of 2023, the Company and its subsidiaries invested a
total of $270.0 million into new and existing investments:

o  $120.0 million senior secured loan agreement with BioCryst.

o  $62.5 million senior secured loan agreement with Reata.

o  $37.5 million senior secured loan agreement with ImmunoGen.

o  The remaining $50 million invested during period was split equally between
two existing investments:

§ $25.0 million for Evolus.

§ $25.0 million for LumiraDx.

·    Additionally, the Company has unfunded commitments for Immunocore and
BioCryst of $25.0 million and $60.0 million respectively that may be funded
over the next six months.

·    The year saw an increase in cash flow of $179.6 million, attributed
to:

o  The prepayment of $62.5 million from Reata on 29 September 2023,
accompanied by prepayment and make-whole fees as of the closing of the Reata
acquisition that totalled a further $15.5 million.

o  Scheduled amortisation payments were received from:

§ the Collegium 2022 loan of $81.2 million.

§ the Akebia loan of $16.0 million.

§ the BMS purchased payments of $19.9 million.

·    On 29 December LumiraDx and Roche Diagnostics Limited announced that
Roche Diagnostics would acquire select parts of LumiraDx for a purchase price
of $295.0 million. The LumiraDx investment was written down as of 31 December
2023 to reflect the expected recoverable net proceeds discounted at a 21.7 per
cent rate to account for remaining risks.

·    In December, the Company's investment in ImmunoGen was marked up by
$10.7 million as of 31 December 2023 to account for the discounted value of
expected prepayments and make-whole fees following the announcement of
AbbVie's definitive agreement to acquire ImmunoGen.

·    The investment manager continues to develop a pipeline of additional
potential investments to further diversify the portfolio that may be
capitalised upon following adjustments to the Company's Discount Control
Mechanism ("DCM") announced this morning following consultation with
shareholders on their preferences for capital allocation.

 

FINANCIAL HIGHLIGHTS

·    Net income return on ordinary activities for the year (after finance
costs and before taxation) of $108.4 million.

·    A 1.5% increase in NAV per ordinary share, from 101.39 cents to
102.93 cents.

·    Ordinary shares closed at 84.0 cents at year end, an 11.6% decrease
from 95.0 cents from 31 December 2022.

·    Including assets and liabilities from its financing subsidiary, BPCR
Limited Partnership, the Company ended the year with total net assets of
$1,340.9 million, comprising $1,102.1 million of investments and $260.8
million of cash less $22.0 million of other net liabilities.

·    The Company has maintained a record of paying a dividend of at least
1.75 cents per share every quarter since that quarter ending 30 June 2018.
Three dividends paid during the year totalled 7.25 cents per share, with a
fourth dividend paid after the year end of 2.96 cents per share comprising a
1.75 cent ordinary dividend and a special dividend of 1.21 cents per share.
Total dividends from 2023 results therefore equated to 10.21 cents per share.

·    The Company repurchased a total of 16,499,477 ordinary shares at an
average price of $0.92 per share and a total cost of $15.3 million from 9
January 2023 to 11 July 2023. Further purchases were not possible as the
Company was in a closed period from 12 July 2023 until 29 December 2023 due to
information received on the LumiraDx investment.

 

POST PERIOD END HIGHLIGHTS

·    Following the completion of AbbVie's acquisition of ImmunoGen, the
loan balance of $37.5 million was repaid to the Company in February, this was
accompanied by prepayment and make-whole fees totalling a further $13.1
million.

·    As per the Company's DCM policy, which states that if the Company's
shares trade at a discount to NAV of greater than 10% over a six-month period,
100% of the proceeds received from debt repayments must be used to repurchase
the Company's shares. This must continue until the discount to NAV at which
the Company's shares trade over a two-week period is less than 5%.

·    From 1 January 2024 to 26 February 2024, in accordance with the
Company's DCM the Company executed significant buyback activity, with
49,041,347 shares repurchased at an average price of $0.93 per share,
amounting to $45.9 million.

·    As announced this morning, the Company has amended its DCM policy to
provide for greater flexibility as to when the Company can freely deploy
capital.

·    Following the end of the year, the Company declared a further
dividend in respect of the last quarter of 2023 of 2.96 cents per share, made
up of an ordinary dividend of 1.75 cents per share in combination with a
special dividend of 1.21 cents per share.

 

SUMMARY

as at 31 December 2023

 Share Price                   Net Assets
 $0.8400                       $1,340.9m
 (31 December 2022: $0.9500)   (31 December 2022: $1,337.5m)

 NAV per Share                 Shares outstanding (m)
 $1.0293                       1,302.7m
 (31 December 2022: $1.0139)   (31 December 2022: 1,319.2m)

 Discount to NAV per Share     Leverage
 18.4%                         0%
 (31 December 2022: 6.3%)      (31 December 2022: 0%)

 Net income per share          Target Dividend
 $0.0828                       7 cents per annum
 (31 December 2022: $0.01336)  (31 December 2022: 7 cents per annum)

PORTFOLIO COMPOSITION

 

                                                    As at 31 December 2023 ($m)  As at 31 December 2022 ($m)  As at 31 December 2023 (%)  As at 31 December 2022 (%)

 Cash and cash equivalents                          260.8                        333.0                        19.4%                       24.9%
 Collegium senior secured loan                      206.3                        287.5                        15.4%                       21.5%
 Insmed senior secured loan                         151.0                        140.0                        11.3%                       10.5%
 LumiraDx senior secured loan and warrants          136.0*                       150.1                        10.1%                       11.2%
 BioCryst senior secured loan                       125.5                        -                            9.4%                        0.0%
 Coherus senior secured loan                        125.0                        120.5                        9.3%                        9.4%
 BMS purchased payments                             83.6                         103.5                        6.2%                        7.7%
 OptiNose senior secured note, shares and warrants  71.5                         72.5                         5.3%                        5.4%
 Evolus senior secured loan                         62.5                         37.5                         4.7%                        2.8%
 UroGen senior secured loan                         50.0                         50.0                         3.7%                        3.7%
 ImmunoGen senior secured loan                      48.2                         -                            3.6%                        0.0%
 Immunocore senior secured loan                     25.0                         25.0                         1.9%                        1.9%
 Akebia senior secured loan                         17.5                         33.5                         1.3%                        2.5%
 Other net liabilities                              (22.0)                       (20.1)                       -1.6%                       -1.5%
 Total net assets                                   1340.9                       1337.5                       100%                        100%

 

* Discount Rates are as set forth in the full Annual Report. For LumiraDx, the
investment was written down as of 31 December 2023 to reflect the expected
recoverable net proceeds discounted at an 21.7 per cent. rate to account for
remaining risks.

Pedro Gonzalez de Cosio, CEO and co-founder of Pharmakon Advisors, LP, the
Investment Manager of BioPharma Credit PLC, said:

"We are pleased to be reporting on another positive year for the Company, with
three new investments successfully completed and further capital allocated to
existing investments.

The Company and its managers remain committed to providing attractive returns
and sustainable income to our investors, uncorrelated to economic cycles and
market movements and we are happy to have again delivered dividends that were
in excess of our annual target with 10.21 cents per share paid to shareholders
as a result of income received during the period. Our cash position remains
strong, with an increase in cash flow of $179.6 million.

Following shareholder feedback, we have announced adjustments to the Company's
DCM and accordingly we look forward to capitalising on an active pipeline of
new investment opportunities to ensure that the Company has the potential to
participate in attractive new investments."

Results presentation

As announced previously, a management presentation for sell side analysts will
be held via a webcast facility at 2pm GMT today. To request details or to
register to attend please RSVP biopharmacredit@buchanan.uk.com

Enquiries

Buchanan

David Rydell / Mark Court / Jamie Hooper / Henry Wilson

+44 (0) 20 7466 5000

biopharmacredit@buchanan.uk.com (mailto:biopharmacredit@buchanan.uk.com)

Notes to Editors

BioPharma Credit PLC is London's only listed specialist investor in debt
from the life sciences industry and joined the LSE on 27 March 2017. The
Company seeks to provide long-term shareholder returns, principally in the
form of sustainable income distributions from exposure to the life sciences
industry. The Company seeks to achieve this objective primarily through
investments in debt assets secured by royalties or other cash flows derived
from the sales of approved life sciences products.

LEI: 213800AV55PYXAS7SY24

 

 

CHAIRMAN'S STATEMENT

 

 

INTRODUCTION

 

2023 marks the sixth full year since the Company's Initial Public Offering
("IPO") on the London Stock Exchange in March 2017. I am pleased to be able to
report on another year of consistent returns and targets met. During 2023, the
Company generated net income per share of $0.0828, which includes the impact
of the mark-up of the ImmunoGen investment and mark-down of the LumiraDx
investment described below. The Company was able to benefit from higher
interest rates as the portfolio has gradually transitioned to floating
coupons.

 

INVESTMENTS

 

Over the course of 2023, the Company and its subsidiaries invested a total of
$270.0 million into new and existing investments. The new investments totaling
$220.0 million are comprised of $37.5 million for ImmunoGen, $120.0 million
for BioCryst, and $62.5 million for Reata. The remaining

$50 million was split between two existing investments, $25.0 million for
Evolus, and $25.0 million for LumiraDx. The Company has additional unfunded
commitments for Immunocore and BioCryst of $25.0 million and $60.0 million
respectively that may be funded over the next six months.

 

Including assets and liabilities from its financing subsidiary, BPCR Limited
Partnership, the Company ended the year with total net assets of $1,340.9
million, comprising $1,102.1 million of investments, $260.8 million of cash
less $22.0 million of other net liabilities.

 

The Company and its subsidiaries saw a $179.6 million increase in cash flow
due to the prepayment of $62.5 million from Reata on 29 September 2023, as
well as the scheduled amortisation payments from the Collegium 2022 loan of
$81.2 million, Akebia loan of $16.0 million and the BMS purchased payments of
$19.9 million. The Reata prepayment was accompanied by prepayment and
make-whole fees totaling $15.5 million as of the closing of the Reata
acquisition, which had a positive material impact on the overall rate of
return of this investment. The Gross IRR for the prepayment of the Reata loan
was 141.4 per cent.* and the Net IRR was 106.1 per cent.*

 

At 30 November 2023, AbbVie announced it had entered into a definitive
agreement to acquire ImmunoGen, Inc. for a total equity value of approximately
$10.1 billion. The loan balance of $37.5 million

was repaid to the Company upon the closing of the acquisition on 12 February
2024. The ImmunoGen repayment was accompanied by prepayment and make-whole
fees totaling $13.1 million. The ImmunoGen investment was marked up by $10.7
million as of 31 December 2023 to account for the discounted value of the
expected prepayment and the make-whole fees.

 

On 29 December 2023, LumiraDx announced the appointment of joint
administrators for two of its subsidiaries and Roche Diagnostics Limited
("Roche") announced that it would acquire select parts of LumiraDx for a
purchase price of $295.0 million. As part of the acquisition, the Company
agreed to provide up to $29.6 million in funding for LumiraDx until the
closing of the acquisition, with Roche agreeing to reimburse up to $27.5
million to the Company in the period to completion of the acquisition which is
expected on or before 30 June 2024. The LumiraDx investment was written down
as of 31 December 2023 to reflect the expected recoverable net proceeds
discounted at a 21.7 percent rate to account for remaining risks.

 

 

DCM AND SHARE BUYBACKS

 

During 2023, the discount control mechanism ("DCM") was triggered, and the
Company was required to use its capital to repurchase shares. The Company was
in a closed period from 12 July 2023 until 29 December 2023 due to information
received on the LumiraDx investment. The Company was not able to implement the
DCM but resumed post year end after the acquisition announcement. The Company
repurchased a total of 16,499,477 Ordinary shares at an average price of $0.92
per share and a total cost of $15.3 million from 9 January 2023 to 11 July
2023. From 1 January 2024 through 26 February 2024 the DCM continued to be in
force and the Company repurchased an additional 49,041,347 shares at an
average price of $0.93 per share and a total cost of $45.9 million. The
current policy of the DCM will remain in place until the shares trade at an
average price that reflects a discount to NAV of less than 5 per cent. for a
two week rolling period. Until such time, the Company will be restricted from
making additional investments. Please see the full Annual Report for a full
description of the current discount mechanism.

 

In addition, the share price triggered a general meeting and continuation
resolution under the DCM. Following a general meeting on 28 December 2023, the
Company announced that shareholders approved the continuation of the Company's
business as a closed- ended investment trust with 94 per cent. of shares
voting, in favor.

 

 

SHAREHOLDER RETURNS

 

The Company reported net income return on ordinary activities after finance
costs and before taxation for the year-ended 2023 of $108.4 million. On 31
December 2023, the Company's Ordinary Shares closed at 84.0 cents, below the
closing price on 31 December 2022 of 95.0 cents. Net Asset Value ("NAV") per
Ordinary Share increased over the same timeframe by 1.54 cents from 101.39
cents to 102.93 cents. The Company made three dividend payments over the
calendar year, relating to 2023, totaling 7.25 cents per share, referencing
net income for the three quarters ending 30 September 2023. The Company was
therefore able to maintain its record of

paying a dividend of at least 1.75 cents per share in every quarter since that
ending 30 June 2018.

 

Following the end of the year, the Company declared a further dividend in
respect of the last quarter of 2023 of 2.96 cents per share made up of an
ordinary dividend of 1.75 cents per share together with a special dividend of
1.21 cents per share that was paid on 15 March 2024. Total dividends from 2023
results reached 10.21 cents per share. The 2023 dividends were covered from
profits.

 

ESG

The Board has supported the Environmental, Social and Governance ("ESG")
programme of Pharmakon Advisors, LP ("Pharmakon" or the "Investment Manager")
during 2023, with progress made in further incorporating ESG as part of the
investment process.

GEOPOLITICAL STATEMENT

The effects of major geopolitical and social risks, including the invasion by
Russia of Ukraine and the war between Israel and Hamas, may have economic
consequences that extend beyond the short term. However, the Company does not
have any direct investments in Russia, Ukraine, or Israel. We will continue to
monitor the situation and will inform shareholders of any material changes to
this assessment.

 

OUTLOOK

The Investment Manager reports a growing pipeline of investment opportunities
as new products and companies enter the market in 2024 and beyond. However,
future growth and further diversification of the Company's portfolio will be
limited by the Company's ability to raise additional funds and use cash for
new investments under the terms of the current DCM.

On behalf of the Board, I should like to express our thanks to Pharmakon for
their continued efforts and achievements on behalf of the Company in 2023, in
particular with regards to the complex process involved in attempting to
maximize the recovery to the Company from the LumiraDx loan, and to our
shareholders for their continued support.

 

 

 

Harry Hyman

Chairman

26 March 2024

 

*Gross IRR and Net IRR are as of the acquisition date. The definitions of
Gross IRR and Net IRR are set forth in the Glossary, available in the full
Annual Report. Past performance is not an indication of future performance.

 

 

INVESTMENT MANAGER'S REPORT

 

Another year of strong investment returns

 

INTRODUCTION TO THE INVESTMENT MANAGER

Pharmakon is pleased to present an update on the Company's portfolio and
investment outlook.

 

New investments, together with Reata's prepayment and higher reference
interest rates, led to total income and net income on the portfolio during
2023 of $136 million and $108 million respectively. Pharmakon's engagement
with counterparties during 2023 resulted in $850 million of new
transactions((1)) for the Company. One investment was prepaid during 2023,
Reata. As of the acquisition closing date, this prepayment generated $16
million in a combination of make-whole and prepayment fees. The Gross IRR for
the prepaid investment was 141.4 per cent(.(2)) and the Net IRR was 106.1 per
cent((3))

 

((1)) New investments figure represents overall commitments inclusive of any
unfunded commitments.

((2)) Gross IRR is as of the acquisition date. The definition of Gross IRR is
set forth in the Glossary, available in the full Annual report . Past
performance is not an indication of future performance.

((3)) Net IRR is as of the acquisition date. The definition of Gross IRR is
set forth in the Glossary available in the full Annual report . Past
performance is not an indication of future performance.

 

BioCryst

On 17 April 2023, the Company and a Private Fund also managed by the
Investment Manager (the "Private Fund"), entered into a definitive senior
secured term loan agreement for up to $450 million with BioCryst
Pharmaceuticals Inc. ("BioCryst") (Nasdaq: BCRX), a biopharmaceutical company
that discovers and commercializes novel, oral, small molecule medicines.

 

BioCryst drew down $300 million at closing on 16 April 2023. The Company's
share of the transaction is $180 million, of which $120 million was funded at
closing by the Company and its subsidiaries. BioCryst has elected the option
to accrue 50 per cent. of their interest due from closing through 31 December
2023 as a payment-in-kind as allowed in the loan agreement. The remaining
three tranches of up to $50 million each will be available through 30
September 2024. The Company's share of the remaining three tranches is $20
million each. The loan has a coupon of 3-month secured overnight financing
rate ("SOFR") plus 7 per cent.

(subject to a 1.75 per cent. floor) and up to 50 per cent. of the interest
during the first 18 months may be paid-in-kind (PIK) at a rate of 3-month SOFR
plus 7.25 per cent., with an

additional consideration of 1.75 per cent. of the total loan amount.

 

BioCryst's commercial product, Orladeyo, is indicated for prophylaxis to
prevent attacks of hereditary angioedema (HAE) in adults and pediatric
patients 12 years and older. BioCryst also has one pipeline product for
BCX10013, a factor D inhibitor being studied in atypical hemolytic uremic
syndrome (aHUS), IgA nephropathy (IgAN), and complement 3 glomerulopathy
(C3G).

 

 Investment type  Total loan amount
 Secured loan     $450m

 Date invested    Company commitment
 17 April 2023    $180m

 Maturity
 April 2028

 

 

ImmunoGen

On 6 April 2023, the Company and the Private Fund entered into a definitive
senior secured loan

agreement for up to $125 million with ImmunoGen, Inc. ("ImmunoGen") (Nasdaq:
IMGN), a biotechnology company focused on developing and commercializing the
next generation of antibody-drug conjugates (ADCs) to improve outcomes for
cancer patients.

 

ImmunoGen drew down $75 million at closing on 6 April 2023. The Company and
its subsidiaries' funded $37.5 million. The loan would have matured in April
2028 and bore interest at SOFR plus 8 per cent. (subject to a 2.75 per cent.
floor), with an additional consideration of 2 per cent. of the total loan
amount.

 

On 30 November 2023, AbbVie announced it had entered into a definitive
agreement to acquire ImmunoGen, Inc. The ImmunoGen investment was marked up by
$10.7 million as of 31 December 2023 to account for the discounted value of
the expected prepayment and the make-whole fees. The ImmunoGen repayment was
accompanied by prepayment and make-whole fees totaling $13.1 million.

 

On 12 February 2024, ImmunoGen repaid its remaining $37.5 million balance to
the Company and the Company received $13.2 million of accrued interest,
additional consideration, and prepayment and make-whole fees.

 

ImmunoGen's commercial product, Elahere, is indicated for the treatment of Fra
positive, platinum-resistant ovarian cancer and is currently being
commercialized in the US. ImmunoGen is also developing pivekimab sunirine for
the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) and
acute myeloid leukemia (AML).

 

 Investment type  Total loan amount
 Secured loan     $125m

 Date invested    Company commitment
 6 April 2023     $63m

 Maturity
 April 2028

 

 

Immunocore

On 8 November 2022, the Company and the Private Fund, entered into a
definitive senior secured loan agreement for up to $100 million with
Immunocore Limited (Nasdaq: IMCR), a biopharmaceutical company focused on
developing a novel class of TCR bispecific immunotherapies designed to treat a
broad range of diseases, including cancer, infectious and autoimmune diseases
("Immunocore").

 

The Company and its subsidiaries funded $25 million of Tranche A of $50
million on 8 November 2022. The remaining $50 million may be drawn by 30 June
2024. The Company's share of Tranche B is $25 million and will be available
through 30 September 2024. Tranche A will mature in November 2028 and bears
interest at 9.75 per cent. per annum along with an additional consideration of
2.5 per cent. paid at funding.

 

 Investment type  Total loan amount
 Secured loan     $100m

 Date invested    Company commitment
 8 November 2022  $50m

 Maturity
 November 2028

 

 

Insmed

On 19 October 2022, the Company and the Private Fund entered into a definitive
senior secured loan agreement for $350 million with Insmed Incorporated
(Nasdaq: INSM), a biopharmaceutical company focused on treating patients with
serious and rare diseases ("Insmed").

 

The Company and its subsidiaries funded $140 million of the $350 million loan
on 19 October 2022. Insmed elected the option to accrue 50 per cent. of their
interest due from closing through 31 December 2023 as a payment-in-kind as
allowed in the loan agreement. The loan will mature in October 2027 and bears
interest at a rate based upon the 3-month SOFR, plus 7.75 per cent. per annum
subject to a SOFR floor of 2.5 per cent. with a one-time additional
consideration of 2 per cent. of the total loan amount paid at funding. 50 per
cent. of the interest during the first 24 months may be paid-in-kind (PIK).

 

 Investment type  Total loan amount
 Secured loan     $350m

 Date invested    Company commitment
 19 October 2022  $140m

 Maturity
 October 2027

 

 

UroGen

On 7 March 2022, the Company and the Private Fund entered into a definitive
senior secured loan agreement for up to $100 million with UroGen Inc. (Nasdaq:
URGN), a biopharmaceutical company dedicated to creating novel solutions that
treat urothelial and specialty cancers ("UroGen").

 

UroGen drew down $75 million at closing and the remaining $25 million on 16
December 2022. The Company and its subsidiaries funded $50 million across the
two tranches. The loan will mature in March

2027 and bears interest at 3-month LIBOR plus 8.25 per cent. per annum subject
to a 1.25 per cent. floor along with a one-time additional consideration of
1.75 per cent. of the total loan amount paid at funding of the first tranche.

 

On 29 June 2023, the UroGen loan was amended with a new term loan rate of
3-month SOFR plus an 8.25 per cent. coupon.

 

On 13 March 2024, the Company entered into an Amendment and Restatement of its
Loan Agreement with UroGen. The Amended and Restated Loan Agreement includes
an additional third and fourth tranche of senior secured loans of $25,000,000
and $75,000,000 respectively. In addition, the interest rate was reduced from
3‑month SOFR plus 8.25 per cent. per annum to 3‑month SOFR plus 7.25 per
cent. per annum, and the SOFR floor was increased from 1.25 per cent. to 2.5
per cent. Under the Amended and Restated Loan Agreement, the third and fourth
tranches were allocated in full to the Private Fund.

 

UroGen markets JELMYTO (mitomycin), a prescription medicine used to treat
adults with a type of cancer of the lining of the upper urinary tract
including the kidney called low-grade Upper Tract Urothelial Cancer (LG-UTUC).
UroGen is also developing UGN-102 (mitomycin) for the treatment of low-grade
intermediate risk non-muscle invasive bladder cancer.

 

 Investment type  Total loan amount
 Secured loan     $200m

 Date invested    Company commitment
 16 March 2022    $50m

 Maturity
 March 2027

 

 

Collegium 2022

On 14 February 2022, the Company along with the Private Fund provided
Collegium Pharmaceutical, Inc. (Nasdaq: COLL), a biopharmaceutical company
focused on developing and commercialising new medicines for responsible pain
management ("Collegium"), with a commitment to enter into a new senior secured
term loan agreement for $650 million.

 

On 22 March 2022, proceeds from the new loan were used to fund Collegium's
acquisition of BDSI as well as repay the outstanding debt of Collegium and
BDSI. At closing, the Company and its subsidiaries invested $325 million in a
single drawing.

 

The four-year loan will have $100 million in amortisation payments during the
first year and the remaining $550 million balance will amortize in equal
quarterly installments. The loan will mature in March 2026 and bears interest
at 3-month LIBOR plus 7.5 per cent. per annum subject to a 1.2 per cent. floor
along with a one-time additional consideration of 2 per cent. of the loan
amount paid upon signing and a one-time additional consideration of 1 per
cent. of the loan amount paid at funding. On 23 June 2023, the Company and the
Private Fund entered into an amendment which modified the loan interest rate
to 3-month SOFR plus 7.50 per cent.

 

Collegium currently markets Xtampza ER, an abuse-deterrent, extended-release,
oral formulation of oxycodone, Nucynta (tapentadol), a centrally acting
synthetic analgesic, and Belbuca (buprenorphine

buccal film), for chronic pain management.

 

 

 Investment type  Total loan amount
 Secured loan     $650m

 Date invested    Company Commitment
 22 March 2022    $325m

 Maturity
 March 2026

 

 

Coherus

On 5 January 2022, the Company and the Private Fund entered into a definitive
senior secured loan agreement for up to $300 million with Coherus BioSciences,
Inc. (Nasdaq: CHRS), a biopharmaceutical company building a leading
immunooncology franchise funded with cash generated by its commercial
biosimilars business ("Coherus").

 

Coherus drew down $100 million at closing, another $100 million on 31 March
2022, and an additional $50 million on 14 September 2022. The remaining $50
million commitment, of which the Company's share was $25 million, lapsed so
there are no additional funding commitments. The Company and its subsidiaries
funded $125 million across the first three tranches. The loan will mature in
January 2027 and bears interest at 3-month LIBOR plus 8.25 per cent. per annum
subject to a 1 per cent. floor along with a one-time additional consideration
of 2 per cent. Of the total loan amount paid at funding of the

first tranche.

 

On 6 February 2023, the Coherus loan was amended to allow for a short-term
waiver to the sales covenant, as well switching the LIBOR component of the
loan coupon to SOFR.

 

On 19 January 2024, Coherus announced that it had entered into a Purchase and
Sales Agreement with Sandoz Inc. (the "Purchase Agreement"). On 5 February
2024, Coherus announced that it had entered into a Consent, Partial Release
and Third Amendment to the Coherus loan agreement, under which certain
subsidiaries and assets of Coherus were released in connection with the
Purchase Agreement. Further, Coherus is permitted to make a partial prepayment
of the principal of the loans outstanding under the Coherus loan agreement in
the amount of $175,000,000 of the outstanding principal balance of
$250,000,000, and the minimum net sales covenant was adjusted. The Company's
portion of such partial principal prepayment would be $87,500,000. Coherus
anticipates making such partial prepayment in Q2 2024.

 

Coherus markets UDENYCA® (pegfilgrastim-cbqv), a biosimilar of Neulasta in
the United States, YUSIMRY (adalimumab-aqvh), a biosimilar of Humira in the
United States, CIMERLI (ranibizumab-eqrn), a biosimilar of Lucentis in the
United States, and LOQTORZI (toripalimab-tpzi), for the treatment of adults
with metastatic or recurrent locally advanced nasopharyngeal carcinoma.

 

 Investment type  Total loan amount
 Secured loan     $250m

 Date invested    Company commitment
 5 January 2022   $125m

 Maturity
 January 2027

 

 

Evolus

On 14 December 2021, the Company and the Private Fund entered into a
definitive senior secured loan agreement for up to $125 million with Evolus
Inc (Nasdaq: EOLS), a biopharmaceutical company that develops, produces, and
markets clinical neurotoxins for aesthetic treatments ("Evolus").

 

The Company and its subsidiaries funded $37.5 million of the first tranche of
$75 million on 29 December 2021. The remaining $50 million was drawn down in
two installments of $12.5 million each on 13 May 2023 and on 14 December 2023.
The Company's share of the final tranche was

$25 million. The loan will mature in December 2027 and bears interest at
3-month LIBOR plus 8.5 per cent. per annum subject to a 1 per cent. floor
along with a one-time additional consideration of 2.25 per cent. Of the total
loan amount paid at funding of the first tranche.

 

On 5 December 2022, the Evolus loan was amended to extend the draw down date
for Tranche B in exchange for a $500,000 amendment fee, of which 50 per cent.
was allocated to the Company.

 

On 9 May 2023, the Evolus loan was amended to: (i) allow Tranche B to be drawn
in two installments, (ii) switching the LIBOR component of the loan coupon to
SOFR, with an additional 0.170 per cent. adjustment, (iii) certain
modifications to the amortization schedule, and (iv) subject to specified
conditions, allow for up to a $15 million revolver facility to be secured by
accounts

receivables and inventory. On 31 May 2023 and 15 December 2023, the Company
funded installments of Tranche B of $12.5 million each. Evolus currently
markets Jeuveau (prabotulinumtoxinA-xvfs), the first and only neurotoxin
dedicated exclusively to aesthetics.

 

 Investment type   Total loan amount
 Secured loan      $125m

 Date invested     Company commitment
 14 December 2021  $63m

 Maturity
 December 2027

 

 

LumiraDx

On 23 March 2021, the Company and the Private Fund entered into a definitive
senior secured loan agreement for $300 million with LumiraDx Investment
Limited and LumiraDx Group Limited (collectively "LumiraDx").

 

The Company and its subsidiaries funded $150 million of the $300 million loan
on 29 March 2021.

The loan was originally due to mature in March 2024 and bore interest at 8 per
cent. per annum along with an additional consideration of 2.5 per cent. of the
loan amount paid at funding and an additional 1.5 per cent. of the loan
payable at maturity. On 28 September 2021, LumiraDx became public via a SPAC
transaction with CA Healthcare Acquisition Corp. and began trading on NASDAQ
under the ticker LMDX. The Company and Private Fund both received 742,924
warrants at a strike price of $10.00, exercisable into common stock of
LumiraDx under the terms of the transaction.

On 17 June 2022, the LumiraDx loan was amended to provide LumiraDx with
certain waivers in exchange for increasing the fee payable at maturity from
1.5 to 3 per cent. of the loan. On 25 July 2022, LumiraDx raised $100 million
in a follow-on offering at a price of $1.75. As part of the financing,
Pharmakon re-tiered its sales covenants, received a facility fee, and was
issued new five-year warrants with a strike price of $1.75, with the original
warrants being cancelled.

On 22 February 2023, the LumiraDx loan was amended to provide LumiraDx with
certain waivers in exchange for increasing the fee payable at maturity from 3
to 9 per cent. of the loan. The LumiraDx loan was amended fourteen times
during the year ended 31 December 2023.

On 29 December 2023, LumiraDx announced the appointment of joint
administrators for two of its subsidiaries and Roche announced that it would
acquire select parts of LumiraDx for a purchase price of $295 million. As part
of the acquisition, the Company agreed to provide up to $29.6 million in
funding for LumiraDx to fund the business until the closing of the
acquisition, Roche agreed to reimburse up to $27.5 million to the Company in
the period to completion of the acquisition. It is anticipated that all of the
sale proceeds of the acquisition will be used to repay certain amounts
outstanding under the Company's loan agreement, and that no sale proceeds will
be distributed to LumiraDx or its shareholders. The investment was written
down to its estimated recoverable value at 31 December 2023 and the
acquisition is anticipated to close on or before 30 June 2024.

 

 Investment type  Total loan amount
 Secured loan     $350m

 Date invested    Company commitment
 23 March 2021    $175m

 Maturity
 See Text*

*Further details of the investment in LumiraDx are set forth in the full
Annual Report.

 

Akebia

On 11 November 2019, the Company and the Private Fund entered into a
definitive senior secured term loan agreement for up to $100 million with
Akebia Therapeutics Inc. (Nasdaq: AKBA), a fully integrated biopharmaceutical
company focused on the development and commercialisation of therapeutics for
people living with kidney disease ("Akebia").

 

Akebia drew down $80 million at closing and an additional $20 million on 10
December 2020. The Company and its subsidiaries funded $50 million across both
tranches. The loan would have matured in November 2024 and bore interest at
LIBOR plus 7.5 per cent. per annum along with a one-time additional
consideration of 2 per cent. of the total loan amount paid at funding. The
Akebia loan began amortising in September 2022.

 

On 18 February 2022, the Akebia loan was amended to provide Akebia certain
waivers. On 15 July 2022, the Akebia loan was amended to provide Akebia with
certain waivers. As a result of this amendment, Akebia made a $25 million
pre-payment, of which $12.5 million went to the Company, as well as a 2 per
cent. prepayment fee.

 

On 30 June 2023, the Akebia loan was amended to end the use of the LIBOR rate
and set a new term loan rate of 3-month SOFR plus a coupon of 7.5 per cent.
and an additional per annum rate of 0.30316 per cent.

 

On 31 October 2023, the Akebia loan was amended to extend the maturity of the
senior secured loan to 31 March 2025, delayed the payment of additional
principal until 31 October 2024 and if certain pre-specified events occurred,
required Akebia to make payments of principal commencing on the original
maturity date through the new extended maturity date and repay all unpaid
principal that would have been due or payable on or after 1 July 2024.

 

On 29 January 2024, Akebia prepaid $17.5 million to the Company, including
$87,500 in prepayment fees.

 

Akebia currently markets Auryxia® (ferric citrate) which is approved in the
US for hyperphosphatemia (elevated phosphorus levels in blood serum) in adult
patients with chronic kidney disease ("CKD") on dialysis and iron deficiency
anaemia in adult patients with CKD not on dialysis.

 

 Investment type   Total loan amount
 Secured loan      $100m

 Date invested     Company commitment
 25 November 2019  $50m

 Maturity
 March 2025

 

 

OptiNose

On 12 September 2019, the Company and the Private Fund entered into a
definitive senior secured note purchase agreement for the issuance and sale of
senior secured notes in an aggregate original principal amount of up to $150
million by OptiNose US, Inc. a wholly owned subsidiary of OptiNose Inc.
(Nasdaq: OPTN), a commercial stage specialty pharmaceutical company
("OptiNose").

 

OptiNose drew a total of $130 million in three tranches: $80 million on 12
September 2019, $30 million on 13 February 2020 and $20 million on 1 December
2020. There are no additional funding commitments.

 

The Company and its subsidiaries funded a total $72 million across all
tranches. The notes mature in September 2024 and bore interest at 10.75 per
cent. per annum along with a one-time additional consideration of 0.75 per
cent. of the aggregate original principal amount of senior secured notes which
the Company was committed to purchase under the facility and 445,696 warrants
exercisable into common stock of OptiNose at a strike price of $6.72. In prior
years, there were two amendments to the OptiNose note purchase agreement,
resulting in re-tiered sales covenants, permission for an equity issuance,
amended amortisation and make-whole provisions, and the issuance of new
three-year warrants with a strike price of $1.60, with the original warrants
being canceled.

 

On 10 August 2022, the OptiNose note and purchase agreement was amended
resulting in re-tiered sales covenants in exchange for an amendment fee of
$780,000, payable upon repayment, of which the Company was allocated $429,000.

 

On 9 November 2022, OptiNose negotiated certain waivers in exchange for a
waiver fee, of which the Company earned $715,000 of the total $1.3 million
waiver fee.

 

On 21 November 2022, OptiNose entered into an Amended and Restated Note
Purchase Agreement (the "A&R NPA"). In the A&R NPA, the sales covenant
was revised and the amortization and make-whole were both modified. The loan
interest was modified from a fixed rate of 10.75 per cent. to a floating rate
equal to 3-month SOFR plus 8.5 per cent., subject to a 2.5 per cent. floor, in
exchange for an amendment fee.

 

On 5 March 2024, OptiNose negotiated an amendment which waived the no 'going
concern' requirement with respect to the 2023 fiscal year and first quarter of
2024. On 8 March 2024, OptiNose negotiated an additional amendment which
extended the Make‑Whole period by 6 months and revised the sales covenants.

 

On 15 March 2024, the FDA approved XHANCE (flucticasone propionate) nasal
spray for the treatment of chronic rhinosinusitis without nasal polyps in
patients 18 years of age or older. OptiNose's leading product, XHANCE
(flucticasone propionate), had already been approved by the FDA in September
2017 for the treatment of chronic rhinosinusitis with nasal polyps in patients
18 years of age or older.

 

 Investment type    Total loan amount
 Secured loan       $130m

 Date invested      Company commitment
 12 September 2019  $72m

 Maturity
 September 2024

 

 

Bristol-Meyers Squibb Company

On 8 December 2017, the Company's wholly-owned subsidiary entered into a
purchase, sale and assignment agreement with a wholly-owned subsidiary of
Royalty Pharma Investments ("RPI"), an affiliate of the Investment Manager,
for the purchase of a 50 per cent. Interest in a stream of payments (the
"Purchased Payments") acquired by RPI's subsidiary from BristolMyers Squibb
Company (NYSE: BMY) through a purchase agreement dated 14 November 2017.

 

As a result of the arrangements, RPI's subsidiary and the Company's subsidiary
are each entitled to the benefit of 50 per cent. of the Purchased Payments
under identical economic terms. The Purchased Payments are linked to tiered
worldwide sales of Onglyza and Farxiga, diabetes agents marketed by
AstraZeneca, and related products. The Company was expected to fund $140
million

to $165 million during 2018 through 2020, determined by product sales over
that period, and will receive payments from 2020 through 2025. The Purchased
Payments are expected to generate attractive risk-adjusted returns in the high
single digits per annum.

 

The Company funded all of the Purchased Payments based on sales from 1 January
2018 to 31 December 2019 for a total of $162 million.

 

 

REALISED INVESTMENTS

 

GBT

On 17 December 2019, the Company and the Private Fund entered into a
definitive senior secured term loan agreement for up to $150 million with
Global Blood Therapeutics Inc. (Nasdaq: GBT), a biopharmaceutical company
focused on innovative treatments that provide hope to underserved patient
communities ("GBT"). GBT drew down $75 million at closing and an additional
$75 million on 20 November 2020. On 14 December 2021 the loan agreement was
amended and restated. The amendment increased the aggregate principal amount
of the loan to $250 million through a $100 million third tranche, which was
drawn on 22 December 2021. The Company and its subsidiaries funded $132.5
million across all three tranches. The loan was due to mature in December 2027
and bore interest at three-month LIBOR plus 7 per cent. per annum

subject to a 2 per cent. floor along with a one- time additional consideration
of 1.5 per cent. of the total loan amount paid upon funding and an additional
2 per cent. payable upon the repayment of the loan. The third tranche also
incurred additional consideration of 1.5 per cent. at the time of funding. As
a part of the amendment in 2021, the Company and its subsidiaries received a
one-time fee equal to 1.25 per cent. of the first two tranches and the
three-year make- whole period was reset to December 2021. On 5 October 2022,
Pfizer acquired GBT and, as a result, GBT repaid its $250 million senior
secured loan. The Company received its $133 million of principal and $43
million in prepayment and make-whole fees. The Company and its subsidiaries
earned a 27.6 per cent. gross internal rate of return* and a 20.7 per cent net
internal rate** of return on its GBT investment.

 

Sarepta

On 13 December 2019, the Company and the Private Fund entered into a
definitive senior secured term loan agreement for up to $500 million with
Sarepta Therapeutics, Inc. (Nasdaq: SRPT), a fully integrated
biopharmaceutical company focused on precision genetic medicine ("Sarepta").
On 24 September 2020 the Sarepta loan agreement was amended, and the loan

amount was increased to $550 million. Sarepta drew down the first $250 million
tranche at closing and an additional $300 million on 2 November 2020. The
Company and its subsidiaries funded $175 million of each tranche for a total
investment of $350 million. The first tranche was originally due to mature in
December 2023 and the second tranche in December 2024. The loan bore interest
at 8.5 per cent. per annum along with a one-time additional consideration of
1.75 per cent. of the first tranche and 2.95 per cent. of the second

tranche paid upon funding and an additional 2 per cent. payable upon the
repayment of the loan. On 12 September 2022, Sarepta announced the early
termination and repayment of its existing senior secured debt with proceeds
from the issuance of $1 billion in convertible bonds. On 12 September 2022,
Sarepta repaid its $550 million senior secured loan.

 

The Company received its $350 million of principal and $22 million in
prepayment, paydown fees, make-whole fees, and accrued interest. The Company
and its subsidiaries earned a 12 per cent. gross internal rate of return* and
9 per cent net internal rate of return** on its Sarepta investment

 

Epizyme

On 4 November 2019, the Company and the Private Fund entered into a definitive
senior secured term loan agreement for up to $70 million with Epizyme, Inc.
(Nasdaq: EPZM), a late-stage biopharmaceutical company developing novel
epigenetic therapies for cancer ("Epizyme").

 

On 3 November 2020 the Epizyme loan agreement was amended, and the loan amount
was increased to $220 million. Epizyme drew down $25 million at closing and an
additional $195 million during 2020. The Company and its subsidiaries funded a
total of $110 million of the Epizyme loan. The loan was originally due to
mature in November 2024 and bore interest at LIBOR plus 7.75 per cent. per
annum along with a one-time additional consideration of 2 per cent. of the
total loan amount paid upon funding. On 27 June 2022, Ipsen announced a
definitive agreement pursuant to which Ipsen would acquire Epizyme. On 12
August 2022, Epizyme repaid its $220 million senior secured loan.

 

The Company received its $110 million of principal and $8 million in
prepayment and make-whole fees. The Company and its subsidiaries earned a 15.2
per cent. gross internal rate of return* and 11.4 per cent net internal rate
of return** on its Epizyme investment.

 

Collegium 2020

 

On 6 February 2020, the Company and the Private Fund entered into a definitive
senior secured term loan agreement for $200 million with Collegium
Pharmaceutical, Inc. (Nasdaq: COLL), a biopharmaceutical company focused on
developing and commercialising new medicines for responsible pain management
("Collegium 2020"). The Company and its subsidiaries funded $165 million of
the $200 million loan on 13 February 2020. The secured loan began amortising
immediately and was due to fully mature in February 2024. The loan bore
interest at three month LIBOR plus 7.5 per cent. per annum subject to a 2 per
cent. LIBOR floor with a one-time additional consideration of 2.5 per cent. of
the loan amount paid upon funding. The loan was repaid in its entirety on 22
March 2022. The Company and its subsidiaries earned a 11.9 per cent. gross
internal rate of return* and 8.9 per cent net internal rate of return** on its
Collegium 2020 investment

 

Biodelivery Sciences

 

On 23 May 2019, the Company entered into a senior secured loan agreement for
up to $80 million with BioDelivery Sciences International (Nasdaq: BDSI), a
commercial- stage specialty pharmaceutical company ("BDSI"). In addition, the
Company acquired 5,000,000 BDSI shares at $5.00 each for a total cost of $25
million in a public offering that took place on 11 April 2019. The first
tranche of the loan for $60 million was funded on 28 May 2019 and the second
$20 million tranche was funded on 22 May 2020. The loan was due to mature in
May 2025 and bore interest at LIBOR plus 7.50 per cent., along with 2 per
cent. additional consideration paid at closing. On 23 September 2021, BDSI
made an early prepayment of $20 million, and made its final payment for the
remainder of the loan on 22 March 2022. The Company earned a 11.9 per cent.
gross internal rate of return* and a 9 per cent net internal rate of return**
on the BDSI loan. The Company sold 46 per cent of its BDSI shares during 2019
at an average price of $6.50 and received $5.60 per remaining shares on the
date of the M&A Transaction. The Company earned

a 11.6 per cent. gross internal rate of return* and a 8.7 per cent net
internal rate of return** on the BDSI equity investment

 

Reata

On 5 May 2023, the Company and the Private Fund, entered into a definitive
senior secured term loan agreement for up to $275 million with Reata
Pharmaceuticals Inc. ("Reata") originally due to mature in May 2028. Tranche A
of $75 million was funded at closing. Tranche B of $50 million and Tranche C
of $75 million were originally due to be drawn after achieving certain
performance-based milestones, and Tranche D of $75 million was originally due
to be available at the Company's discretion after achieving certain
sales-based milestones. The loan had a coupon of 3-month secured overnight
financing rate ("SOFR"), plus 7.5 per cent. (subject to a 2.5 per cent.
floor).

 

There was also a 2 per cent. upfront fee upon each draw. The interest only
period for the loan was for 3 years but could have been extended to 4 years if
trailing twelve month sales are greater than $250 million. The Company's share
of the transaction was $137.5 million, of which $37.5 million was funded at
closing.

 

On 10 July 2023, the Company funded Tranche B of the Reata loan for $25
million.

 

On 28 July 2023, Inc. ("Biogen") Biogen announced a definitive agreement
pursuant to which Biogen will acquire Reata for an enterprise value of
approximately $7.3 billion. The acquisition closed on 29 September 2023. As of
the acquisition closing date, the Company received prepayments including $15.5
million in prepayment and make-whole fees.

 

 

MARKET ANALYSIS

 

The life sciences industry is expected to continue to have substantial capital
needs during the coming years as the number of products undergoing clinical
trials continues to grow. All else being equal, companies seeking to raise
capital are generally more receptive to non-dilutive debt financing
alternatives at times when equity markets are soft, increasing the number and
size of fixed-income investment opportunities for the Company, and will be
more inclined to issue equity or convertible bonds at times when equity
markets are strong. A good indicator

of the life sciences equity market is the New York Stock Exchange
Biotechnology Index ("BTK Index"). While there was substantial volatility
during the period, the BTK index increased 3 per cent. during 2023, compared
to a 4 per cent. decrease during 2022.*** Global equity issuance by life
sciences companies during 2023 was $45 billion, a 31 per cent. increase from
the $34.4

billion issued during 2022.**** Similarly, convertible bond issuance by life
sciences companies increased to $9.7 billion in 2023 from $7.3 billion in
2022.**** We anticipate 2024 equity and convertible bond issuance to remain
comparable to 2023 levels which should continue to support appetite for
non-dilutive debt during the remainder of 2024.

 

Acquisition financing is an important driver of capital needs in the life
sciences industry in general and a source of investment opportunities. An
active M&A market helps drive opportunities for investors such as the
Company, as acquiring companies need capital to fund acquisitions. Global life
sciences M&A volume during 2023 was $189 billion, a 108 per cent. increase
from the $91 billion witnessed during 2022, driven mainly by the volatility in
the equity markets. We are encouraged by the number of M&A opportunities
that are starting to build up

which should lead to a more active market in the near term.****

 

USD LIBOR

 

On 5 March 2021, the Financial Conduct Authority ("FCA"), the regulatory
supervisor of USD LIBOR's administrator ("IBA") announced in a public
statement the future cessation of the 3-month USD LIBOR tenor setting. As of
that date, 30 June 2023, all available tenors of USD LIBOR have either
permanently or indefinitely ceased to be provided by IBA. As of 30 June 2023
the benchmark replacement rate is based on Secured Overnight Financing Rate
("SOFR"), and all LIBOR-based interest payments will now be calculated with
SOFR beginning on the respective effective date. The Company has eleven loans
with coupons that reference 3-month USD SOFR and five have a 2.5 per cent.
floor or greater and six have a floor ranging from 1 per cent. to 2.00 per
cent. As of 31 December 2023, the 3-month SOFR rate was 5.33 per cent,
significantly above the floors in the eleven loans.

 

INTERNATIONAL OUTLOOK

 

The invasion of Ukraine by Russia and the war between Israel and Hamas has led
to increased market volatility and widespread sanctions on Russian assets and
individuals, contributing to the high inflation introduced by the pandemic.
While the portfolio has no direct exposure to Russia, Ukraine, Belarus, or
Israel, we remain vigilant in monitoring these major events closely and will
inform investors of any material changes.

 

 

INVESTMENT OUTLOOK

 

We expect our investment pipeline to grow as new products and companies enter
the market in 2024 and beyond. Pharmakon's extensive network and thorough
approach will continue to identify strong investment opportunities. We remain
focused on our mission of creating the premier dedicated provider of debt
capital to the life sciences industry while generating attractive returns and
sustainable income to investors.

 

Although the global economic outlook remains uncertain, Pharmakon remains
confident of its ability to deliver its target dividend yield to its
investors.

 

Pedro Gonzalez de Cosio

Co-founder and CEO, Pharmakon

 

26 March 2024

 

 

* Gross IRR is set forth in the Glossary available in the full Annual Report.
Past performance is not an indication of future performance.

** Net IRR is set forth in the Glossary available in the full Annual Report.
Past performance is not an indication of future performance.

*** Source: BTK Index

**** Source: Bloomberg

 

 

The ESG policy is set out in the full Annual Report.

 

STRATEGIC OVERVIEW

 

INVESTMENT OBJECTIVE

The Company aims to generate long-term Shareholder returns, predominantly in
the form of sustainable income distributions from exposure to the life
sciences industry.

INVESTMENT POLICY

The Company will seek to achieve its investment objective predominantly
through direct or indirect exposure to Debt Assets, which include Royalty
Investments, Senior Secured Debt, Unsecured Debt and Credit Linked Notes.

THE COMPANY MAY ACQUIRE DEBT ASSETS:

·     Directly from the entity issuing the Debt Asset (a "Borrower"),
which may be: (i) a company operating in the life sciences industry (a
"LifeSci Company"); or (ii) an entity other than a LifeSci Company which
directly or indirectly holds an interest in royalty rights to certain
products, including any investment vehicle or special purpose vehicle
("Royalty Owner");

·     Or in the secondary market.

The Company may also invest in equity issued by a LifeSci Company, acquired
directly from the LifeSci Company or in the secondary market. "Debt Assets"
will typically comprise:

·     Royalty debt instruments

Debt issued by a Royalty Owner where the Royalty Owner's obligations in
relation to the Debt are secured as to repayment of principal and payment of
interest by Royalty Collateral.

·     Priority royalty tranches

Contract with a Borrower that provides the Company with the right to receive
payment of all or a fixed percentage of the future royalty payments receivable
in respect of a Product (or Products) that would otherwise belong to the
Borrower up to a fixed monetary amount or a pre-set rate of return, with such
royalty payment being secured by Royalty Collateral in respect of that Product
(or Products).

·     Senior secured debt

Debt issued by a LifeSci Company, and which is secured as to repayment of
principal and payment of interest by a first priority charge over some or all
of such LifeSci Company's assets, which may include: (i) Royalty Collateral;
or (ii) other intellectual property and marketing rights to the Products of
that LifeSci Company.

·     Unsecured debt

Debt issued by a LifeSci Company which is not secured or is secured by a
second lien on assets of the Borrower.

·     Credit linked notes

Derivative instruments referencing Debt Assets, being a synthetic obligation
between the Company and another party where the repayment of principal and/or
the payment of interest is based on the performance of the obligations under
the underlying Debt Assets.

 

"Royalty Collateral" means, with respect to a Debt Asset, (i) future payments
receivable by the Borrower on a Product (or Products) in the form of royalty
payments or other revenue sharing arrangements; or (ii) future distributions
receivable by the Borrower based on royalty payments generated from a Product
(or Products); or (iii) both  (i) and  (ii)"Debt" includes loans, notes,
bonds and other debt instruments and securities, including convertible debt,
and Priority Royalty Tranches.

Borrowers will predominantly be domiciled in the US, Europe and Japan, though
the Company may also acquire Debt Assets issued by Borrowers in other
jurisdictions.

 

 

INVESTMENT RESTRICTIONS AND PORTFOLIO DIVERSIFICATION

The Company will seek to create a diversified portfolio of investments by
investing across a range of different forms of Debt Assets issued by a variety
of Borrowers. In particular, the Company will observe the following
restrictions when making investments in accordance with its investment policy:

 

·      no more than 25 per cent. of the Company's gross assets will be
exposed to any single Borrower or investment;

·      no more than 35 per cent. of the Company's gross assets will be
invested in Unsecured Debt;

·      no more than 15 per cent. of the Company's gross assets will be
invested in equity securities issued by LifeSci Companies; and

·      the Company will invest no more than 10 per cent., in aggregate,
of gross asset value at the time of acquisition in other listed closed‐ended
investment funds.

 

Each of these investment restrictions will be calculated at the time of each
proposed investment. In the event that any of the above limits are breached at
any point after the relevant investment has been made (for instance, as a
result of any movements in the value of the Company's total assets), there
will be no requirement to sell any investment (in whole or in part).

 

CASH MANAGEMENT

The Company's uninvested capital may be invested in cash instruments or bank
deposits for cash management purposes.

 

HEDGING

The Company does not propose to enter into any hedging or other derivative
arrangements other than as may from time to time be considered appropriate for
the purposes of efficient portfolio management. The Company will not enter
into such arrangements for investment purposes.

 

BUSINESS AND STATUS OF THE COMPANY

The Company is registered in England as a public limited company and is an
investment company in accordance with the provisions of Section 833 of the
Companies Act 2006.

 

The principal activity of the Company is to carry on business as an investment
trust. The Company intends at all times to conduct its affairs so as to enable
it to qualify as an investment trust for the purposes of Sections 1158/1159 of
the Corporation Tax Act 2010 ('S1158/1159"). The Directors do not envisage any
change in this activity in the foreseeable future.

The Company has been granted approval from HM Revenue & Customs ('HMRC")
as an investment trust under S1158/1159 and will continue to be treated as an
investment trust company, subject to there being no serious breaches of the
conditions for approval. The Directors are of the opinion that the Company has
conducted its affairs for the year ended 31 December 2023 so as to be able to
continue to qualify as an investment trust.

The Company has two wholly-owned subsidiaries, BPCR Limited Partnership and
BPCR GP Limited, and one indirectly wholly-owned subsidiary, BPCR Ongdapa
Limited, details of which can be found in Note 14 to the financial statements.

 

STAKEHOLDER ENGAGEMENT - SECTION 172(1) STATEMENT

 

OVERVIEW

The Directors' overarching duty is to promote the success of the Company for
the benefit of its shareholders, having regard to the interests of its
stakeholders, as set out in section 172(1) of the Companies Act 2006. The
Directors have considered each aspect of this section of the Act and consider
that the information set out below is particularly relevant in the context of
the Company's business as an externally managed investment company which does
not have any employees or suppliers.

 

The importance of stakeholders is taken into account at every Board meeting.
All discussions involve careful consideration of the longer-term consequences
of any decisions and their implications for stakeholders.

 

STAKEHOLDERS

The Board seeks to understand the needs and priorities of the Company's
stakeholders and these are taken into account during all its discussions and
as part of its decision-making. The Board believes that the Company's key
stakeholders comprise its shareholders, clients and service providers. The
section below discusses why these stakeholders are considered of importance to
the Company and the actions taken to ensure that their interests are taken
into account. The Company recognises the importance of maintaining high
standards of business conduct and seeks to ensure that these are applied in
all of its business dealings and in its engagement with stakeholders. Further
information on the impact of the Company's operations on the community and the
environment is set out below.

The Company's mechanisms for engaging with its stakeholders are set out below.
These are kept under review by the Directors and are discussed on a regular
basis at Board meetings to ensure that they remain effective. The Company is
an investment trust and has no employees. It has therefore not identified
employees as a stakeholder group.

For more information on the purpose, culture and values of the Company, and
the processes which the Board has put in place to ensure these, see the
Corporate Governance Statement as set out in the full Annual Report.

 

 

SHAREHOLDERS

 

Importance

Continued shareholder support and engagement are critical to the existence of
the Company and the delivery of its long-term strategy and engagement with
shareholders is given a high priority by both the Board and the Investment
Manager.

 

How the Company engages

The Chairman ensures that the Board as a whole has a clear understanding of
the views of shareholders by receiving regular updates from the Brokers and
Investment Manager. The Investment Manager and the Company's Brokers are in
regular contact with major shareholders and report the results of all meetings
and the views of those shareholders to the Board on a regular basis. The
Investment Manager provides regular investor updates and presentations to
shareholders. The Chairman and the other Directors are available to attend
these meetings with shareholders if required. Relations with shareholders are
also considered as part of the annual Board evaluation process. For further
details regarding this process see the full Annual Report.

 

All shareholders are encouraged to attend and vote at annual general meetings
("AGM"), during which the Board and the Investment Manager will be available
to discuss issues affecting the Company and answer any questions. Further
information regarding the AGM is detailed in the full Annual Report.

 

Shareholders wishing to raise questions or concerns directly with the
Chairman, Senior Independent Director or Company Secretary, outside of the
AGM, should do so using the contact details provided below.

Although the Company has been established with an indefinite life, the
Articles provide that a continuation vote be put to shareholders periodically.
The next continuation vote will be put to shareholders in 2025.

During the year, as the Company's shares had on average, traded at a discount
in excess of 10 per cent. to the Net Asset Value per Ordinary Share over a
rolling 12 month period, the Company was required to propose a Continuation
Resolution to shareholders. The Continuation Resolution was proposed to
shareholders as an ordinary resolution at the general meeting held on 28
December 2023 at which 94.06 per cent. of total votes were cast in favour of
the continuation of the Company.

 

 

CLIENTS

 

Importance

The investments made by the Company support the large capital needs of its
portfolio companies, supporting their research and development budgets for
life sciences products and enable them to achieve their investment objective.

 

How the Company engages

The Company's clients are pharmaceutical and biotechnology companies within
the life sciences industry to which it provides debt capital. The Investment
Manager is highly experienced in this area with a strong track record of
meeting the capital needs of its clients. The Investment Manager meets
regularly with the management teams of current and prospective investee
companies to enhance relationships and to understand their views and capital
requirements.

 

The Directors receive updates from the Investment Manager on the companies
within its investment portfolio at all Board meetings, and outside of meetings
as appropriate.

 

Further information on the Company's engagement with investee companies during
the year, including case studies regarding their products, is set out above.

 

 

SERVICE PROVIDERS

 

Importance

In order to function as an investment trust on the Premium Segment of the
London Stock Exchange, the Company relies on a number of reputable advisers
for support in complying with all relevant legal and regulatory obligations.

 

How the Company engages

 

The Company's day-to-day operational functions are delegated to a number of
third-party service providers, each engaged under separate contracts. The
Company's principal service providers include the Investment Manager, Company
Secretary, Joint Brokers, Administrator, Legal Adviser, Auditor and the
Registrar.

The Board keeps the ongoing performance of the Investment Manager under
continual review and conducts an annual appraisal of the Investment Manager,
along with the performance of all other third-party service providers in
December each year. The Investment Manager has executed the investment
strategy according to the Board's expectations and it is the opinion of the
Directors that the continuing appointment of Pharmakon, as the Investment
Manager, is in the interests of shareholders as a whole.

The Audit and Risk Committee reviews and evaluates the control environments in
place at each service provider. Further details regarding the role of the
Audit and Risk Committee are set out in the full Annual Report.

Further information about the review of service providers and the culture of
the Investment Manager is set out in the full Annual Report.

 

 

KEY PERFORMANCE INDICATORS

 

The Company assesses its performance in meeting its investment objectives
using the following Key Performance Indicators ("KPIs"):

 

NAV PERFORMANCE

 

The NAV at 31 December 2023 was $1.0293 per Share, compared to $1.0139 per
Share at 31 December 2022.

 

A full description of the Company's performance for the year ended 31 December
2023 is included in the Investment Manager's Report above.

 

SHARE PRICE RETURN

The Company's Share price at 31 December 2023 was $0.8400, compared to $0.9500
at 31 December 2022. The Company's Share price at 31 December 2022 was
$0.9500, giving a return since 31 December 2021 of -1.9 per cent.

SHARE PRICE DISCOUNT/PREMIUM TO NAV PER SHARE

Under the terms of the Discount Control Mechanism ("DCM"), described in the
Company's Prospectuses dated 1 March 2017 and 14 March 2018, if the shares of
the Company trade at a discount greater than 5 per cent. over a three-month
period (the "First Trigger"), the Company is required to apply up to 50 per
cent. of proceeds from debt repayments in purchasing Company shares until such
time that the two-week discount is less than 1 per cent. In addition, if the
discount is greater than 10 per cent. over a six-month period (the "Second
Trigger"), the Company is required to apply up to 100 per cent. of proceeds
from debt repayments until such time that the two-week discount is less than 1
per cent. If the Company's shares trade at a discount in excess of 10 per
cent. to the net asset value per share over a 12 month rolling period, a
general meeting and continuation resolution under the DCM is triggered.

On 7 November 2022, the DCM was updated so that the trigger levels remain at
previous levels but provide for greater flexibility as to when the Company can
freely deploy capital:

·      The First Trigger will remain at a 5 per cent. discount to NAV
and the Company will be required to apply 50 per cent. of the principal being
returned to repurchase shares until such time that the discount to NAV over a
two-week period is less than 5 per cent. (compared with less than 1 per cent.
previously).

·      The Second Trigger will remain at a 10 per cent discount to NAV
and the Company will be required to apply 100 per cent. of the principal being
returned to repurchase shares until such time that the discount to NAV over a
two-week period is less than 5 per cent. (compared with less than 1 per cent.
previously).

During the 12 month rolling period ended 1 November 2023, the Company's shares
traded at a discount in excess of 10 per cent. to the net asset value per
share triggering a general meeting and continuation resolution under the DCM.
On 28 December 2023, the Company announced at the general meeting that
shareholders approved the continuation of the Company's business as a
closed-ended investment trust with 94 per cent. of shares voting, in favor.

ONGOING CHARGES

The Company's ongoing charges ratio is shown in the table below.

 

                                             Year ended        Year ended
                                             31 December 2023  31 December 2022
                                             %                 %
 Ongoing charges excluding performance fee*  1.1               1.1
 Performance fee                             0.9               1.5
 Ongoing charges including performance fee   2.1               2.6

* Ongoing charges are the Company's expenses (excluding performance fees)
expressed as a percentage of its average monthly net assets and follow the AIC
recommended methodology.

 

DIVIDENDS

Dividend payments totaling 5.25 cents per Ordinary Share, including one
special dividend totaling 2 cents have been paid during the year ended 31
December 2023. A dividend was paid in respect of the last quarter of 2023
totaling 1.75 cents per Ordinary Share, including a special of 1.21 cents on
15 March 2024. Dividends totaling 11.50 cents per Ordinary Share, including
one special dividend of 4.50 cents, were paid during the year ended 31
December 2022.

 

RISK MANAGEMENT AND THE INTERNAL CONTROL ENVIRONMENT

 

The role of the Board

A formal risk identification and assessment process has been adopted by the
Company resulting in a risk framework document which summarises the key risks
and their mitigation.

The Board undertakes a formal risk review with the assistance of the Audit and
Risk Committee at least twice a year in order to robustly assess the
effectiveness of the Company's risk management and internal control systems.
During the course of its review in respect of the year ended 31 December 2023,
the Board has not identified, nor been advised of any failings or weaknesses
which it has determined to be of a material nature. The principal risks and
uncertainties which the Company faces are set out below.

 

Principal risks and uncertainties

The Board of Directors has overall responsibility for risk management and
internal control of the Company. The Board recognises that risk is inherent in
the operation of the Company and that effective risk management is key to the
success of the organisation. The Board has delegated responsibility for the
assurance of the risk management process and the review of mitigating controls
to the Audit and Risk Committee.

The principal risks and the Company's policies for managing these risks are
set out below and the policy and practice with regard to financial instruments
are summarised in Note 16 to the financial statements.

There were no changes to these risks in the current year or at the date of
this report.

The recent events surrounding the LumiraDx investment help illustrate some of
the risks and mitigants described below. LumiraDx faced financial difficulties
that exposed the Company to counterparty risk as it became clear that the
Company will be unable to recover the full principal and fees owed. However,
the positive attributes of the collateral and the investment manager's
diligent efforts are expected to result in the Company being able to
ultimately recover a significant portion of its investment.

 

 Risk                                                                           Description and mitigation
 Failure to achieve target returns                                              The target returns are targets only and are based on financial projections
                                                                                that are themselves based on assumptions regarding market conditions, economic
                                                                                environment, availability of investment opportunities and investment-specific
                                                                                assumptions that may not be consistent with conditions in the future.

                                                                                The Company seeks to achieve its investment objective predominantly through
                                                                                direct or indirect exposure to debt assets. Debt assets typically comprise
                                                                                royalty debt instruments, priority royalty tranches, senior secured debt,
                                                                                unsecured debt and credit-linked notes. A variety of factors, including lack
                                                                                of attractive investment opportunities, defaults and prepayments under debt
                                                                                assets, inability of the Company to obtain debt at an appropriate rate,
                                                                                changes in the life sciences industry, exchange rates, government regulations,
                                                                                the non-performance (or underperformance) of any life sciences product (or any
                                                                                life sciences company) could adversely impact the Company's ability to achieve
                                                                                its investment objective and deliver the target returns. A failure by the
                                                                                Company to achieve its target returns could adversely impact the value of the
                                                                                Shares and lead to a loss of investment.

                                                                                The Company has an investment policy to achieve a balanced investment with a
                                                                                diversified asset base and has investment restrictions in place to limit
                                                                                exposure to potential risk factors. These factors enable the Company to build
                                                                                a diversified portfolio that should deliver returns that are in line with its
                                                                                stated target return.

 The success of the Company depends on the ability and expertise of the         In accordance with the Investment Management Agreement, the Investment Manager
 Investment Manager                                                             is responsible for the investment management of the Company's assets. The
                                                                                Company does not have its own employees and all of its Directors are appointed
                                                                                on a non-executive basis. All investment and asset management decisions are
                                                                                made by the Investment Manager (or any delegates thereof) and not by the
                                                                                Company or the Directors and, accordingly, the Company is completely reliant
                                                                                upon, and its success depends on, the Investment Manager and its personnel,
                                                                                services and resources. The Investment Manager is required, under the terms of
                                                                                the Investment Management Agreement, to perform in accordance with the Service
                                                                                Standard. The Investment Manager does not submit individual investment
                                                                                decisions to the Board for approval and the Board does not supervise the due
                                                                                diligence performed by the Investment Manager. As part of its asset management
                                                                                decisions, the Investment Manager may from time to time make commitments for
                                                                                future investments for which the Company may need to raise funds in the future
                                                                                by issuing equity and/or debt or by selling all or part of other investments
                                                                                to raise liquidity.

                                                                                The Company is entitled to terminate the Investment Management Agreement if
                                                                                the Investment Manager has (i) committed fraud, gross negligence or wilful
                                                                                misconduct in the performance of its obligations under the Investment
                                                                                Management Agreement, or (ii) breached its obligations under the Investment
                                                                                Management Agreement, and the Company is reasonably likely to suffer a loss
                                                                                arising directly or indirectly out of or in connection with such breach of an
                                                                                amount equal to or greater than 10 per cent. of the NAV as at the date of the
                                                                                breach. The Investment Management Agreement may also be terminated at the
                                                                                Company's discretion on not less than six months' notice to the Investment
                                                                                Manager.

                                                                                Under the terms of the Investment Management Agreement, the Investment Manager
                                                                                is only liable to the Company (and will only lose its indemnity) if it has
                                                                                committed fraud, gross negligence or wilful misconduct or acted in bad faith,
                                                                                or knowingly violated applicable securities' laws. The performance of the
                                                                                Company is dependent on the diligence, skill and judgement of certain key
                                                                                individuals at the Investment Manager, including Pedro Gonzalez de Cosio and
                                                                                other senior investment professionals and the information and investments'
                                                                                pipeline generated through their business development efforts. On the
                                                                                occurrence of a Key Person Event (as defined in the Investment Management
                                                                                Agreement), the Company may be entitled to terminate the Investment Management
                                                                                Agreement with immediate effect (subject to the Investment Manager's right to
                                                                                find an appropriate replacement to be approved by the Board (such approval not
                                                                                to be unreasonably withheld or delayed) within 180 days)).

                                                                                However, if the Company elects to exercise this right, it would be required to
                                                                                pay the Investment Manager a termination fee equal to either 1 per cent. or 2
                                                                                per cent. of the invested NAV (depending on the reason for the Key Person
                                                                                Event), as at the date of such termination. If the Company elects not to
                                                                                exercise this right, the precise impact of a Key Person Event on the ability
                                                                                of the Company to achieve its investment objective and target returns cannot
                                                                                be determined and would depend inter alia on the ability of the Investment
                                                                                Manager to recruit individuals of similar experience, expertise and calibre.
                                                                                There can be no guarantee that the Investment Manager would be able to do so
                                                                                and this could adversely affect the ability of the Company to meet its
                                                                                investment objective and target returns and may adversely affect the NAV and
                                                                                Shareholder returns and result in a substantial loss of a Shareholder's
                                                                                investment.

                                                                                The Investment Manager has extensive expertise and a track record of
                                                                                successfully investing in debt and other cash flows backed by life sciences
                                                                                products. The Investment Management Agreement provides attractive incentives
                                                                                for the Investment Manager to perform prudently and in the best interests of
                                                                                the Company. In addition, the Investment Manager and its affiliates own
                                                                                approximately 6 per cent. of the Company as at 31 December 2023, creating a
                                                                                strong alignment of interests between the Investment Manager and its
                                                                                affiliates and Shareholders of the Company.

 The Company may from time to time commit to make future investments that       From time to time, the Company may commit to make future investments for which
 exceed its current liquidity                                                   the Company will need to raise funds by issuing equity and/or debt, or by
                                                                                selling all or part of other investments. Investment opportunities may require
                                                                                the Company to fund transactions in two or more tranches, with the later
                                                                                tranches to be funded six or more months in the future. Refusing to offer such
                                                                                later tranches would decrease the attractiveness of the Company's investment
                                                                                proposals and harm the Company's ability to successfully deploy its capital.
                                                                                Requiring the Company to maintain low-yielding cash balances sufficient to
                                                                                fund all such later tranches at the time of the initial commitment would
                                                                                decrease the average yield on the Company's assets, adversely impacting the
                                                                                returns to investors, and may also result in missed investment opportunities.
                                                                                However, in order to fund all such later tranches, the Company could be forced
                                                                                to issue debt, sell assets or renegotiate with the party to which it has
                                                                                committed the funding on unattractive terms. Furthermore, there can be no
                                                                                assurance that the Company will always be able to raise sufficient liquidity
                                                                                (by issuing equity and/or debt, or by selling investments) to meet its funding
                                                                                commitments. If the Company were to fail to meet its funding commitments, the
                                                                                Company could be in breach of its contractual obligations, which could
                                                                                adversely affect the Company's reputation, could result in the Company facing
                                                                                legal action from its counterparty, and could adversely affect the Company's
                                                                                financial results.

                                                                                The Investment Manager believes that the risks associated with such unfunded
                                                                                commitment is manageable without undue risk. The Investment Manager has
                                                                                extensive expertise in raising debt secured by cash flows from life sciences
                                                                                products and has extensive relationships with banks and other financial
                                                                                institutions who can be called on to provide debt financing to the Company in
                                                                                order to raise liquidity. In addition, the Investment Manager has expertise
                                                                                purchasing and selling life sciences debt assets in the secondary market and
                                                                                has extensive relationships with the major participants in the life-sciences
                                                                                debt market who would be the likely purchasers of any assets offered for sale
                                                                                by the Company in order to raise liquidity.

 The Investment Manager's ability to source and advise appropriately on         Returns on the shareholders' investments will depend upon the Investment
 investments                                                                    Manager's ability to source and make successful investments on behalf of the
                                                                                Company. There can be no assurance that the Investment Manager will be able to
                                                                                do so on an ongoing basis. Many investment decisions of the Investment Manager
                                                                                will depend upon the ability of its employees and agents to obtain relevant
                                                                                information. There can be no guarantee that such information will be available
                                                                                or, if available, can be obtained by the Investment Manager and its employees
                                                                                and agents. Furthermore, the Investment Manager will often be required to make
                                                                                investment decisions without complete information or in reliance upon
                                                                                information provided by third parties that is impossible or impracticable to
                                                                                verify. For example, the Investment Manager may not have access to records
                                                                                regarding the complaints received regarding a given life science product or
                                                                                the results of research and development related to products. Furthermore, the
                                                                                Company may have to compete for attractive investments with other public or
                                                                                private entities, or persons, some or all of which may have more capital and
                                                                                resources than the Company.

                                                                                These entities may invest in potential investments before the Company is able
                                                                                to do so or their offers may drive up the prices of potential investments,
                                                                                thereby potentially lowering returns and, in some cases, rendering them
                                                                                unsuitable for the Company. An inability to source investments would have a
                                                                                material adverse effect on the Company's profitability, its ability to achieve
                                                                                its target returns and the value of the Shares.

                                                                                The Investment Manager believes that sourcing investments is one of its
                                                                                competitive advantages. The Investment Manager's professionals, together with
                                                                                those at its affiliate RP Management LLC, accessible through the Shared
                                                                                Services Agreement, have complementary scientific, medical, licensing,
                                                                                operating, structuring and financial backgrounds which the Investment Manager
                                                                                believes provide a competitive advantage in sourcing, evaluating, executing
                                                                                and managing credit investments in the life sciences industry.

 There can be no assurance that the Board will be able to find a replacement    Under the terms of the Investment Management Agreement, the Investment
 investment manager if the Investment Manager resigns                           Management Agreement may be terminated by: (A) the Investment Manager on not
                                                                                less than six months' notice to the Company, such notice not to expire earlier
                                                                                than 18 months following Admission; or (B) the Company on not less than six
                                                                                months' notice to the Investment Manager, such notice not to expire earlier
                                                                                than: (i) 36 months following Admission, unless approved by Shareholders by
                                                                                ordinary resolution; and (ii) 18 months following Admission, in any event. The
                                                                                Board would, in these circumstances, have to find a replacement investment
                                                                                manager for the Company and there can be no assurance that a replacement with
                                                                                the necessary skills and experience would be available and/or could be
                                                                                appointed on terms acceptable to the Company. In this event, the Board may
                                                                                have to formulate and put forward to Shareholders proposals for the future of
                                                                                the Company which may include its merger with another investment company,
                                                                                reconstruction or winding up. It is possible that, following the termination
                                                                                of the Investment Manager's appointment, the Investment Manager will continue
                                                                                to have a role in the investment management of certain assets, where a debt
                                                                                asset is shared with one or more other entity managed by the Investment
                                                                                Manager that continue to retain the Investment Manager's services.

                                                                                In the event the Investment Manager resigns, the Board will put forward to
                                                                                Shareholders proposals for the future of the Company which may include its
                                                                                merger with another investment company, reconstruction or winding up. Entities
                                                                                affiliated with the Investment Manager own approximately 6 per cent. of the
                                                                                Company as at 31 December 2023. This affiliate ownership level, coupled with
                                                                                the fact that the Investment Manager is fairly compensated, provide further
                                                                                incentive for them to remain as Investment Manager to the Company.

 Concentration in the Company's portfolio may affect the Company's ability to   The Company's published investment policy allows the Company to invest up to
 achieve its investment objective                                               25 per cent. of the Company's assets in a single debt asset or in debt assets
                                                                                issued to a single borrower. While the investment limits in the investment
                                                                                policy have been set keeping in mind the debt capital requirements of the life
                                                                                sciences industry and the investment opportunities available to the Investment
                                                                                Manager, it is possible that the Company's portfolio may be significantly
                                                                                concentrated at any given point in time.

                                                                                Concentration in the Company's portfolio may increase certain risks to which
                                                                                the Company is subject, some or all of which may be related to events outside
                                                                                the Company's control. These would include risks around the creditworthiness
                                                                                of the relevant borrower, the nature of the debt asset and of any life
                                                                                sciences product(s) in question. The occurrence of these situations may result
                                                                                in greater volatility in the Company's investments and, consequently, its NAV,
                                                                                and may materially and adversely affect the performance of the Company and the
                                                                                Company's returns to shareholders. Such increased concentration of the
                                                                                Company's assets could also result in greater losses to the Company in adverse
                                                                                market conditions than would have been the case with a less concentrated
                                                                                portfolio, and have a material adverse effect on the Company's financial
                                                                                condition, business, prospects and results of operations and, consequently,
                                                                                the Company's NAV and/or the market price of the Shares.

 Life sciences products are subject to intense competition and various other    The biopharmaceutical and pharmaceutical industries are highly competitive and
 risks                                                                          rapidly evolving. The length of any life sciences product's commercial life
                                                                                cannot be predicted. There can be no assurance that the life sciences products
                                                                                will not be rendered obsolete or non-competitive by new products or
                                                                                improvements made to existing products, either by the current marketer of the
                                                                                life sciences products or by another marketer. Adverse competition,
                                                                                obsolescence or governmental and regulatory life sciences policy changes could
                                                                                significantly impact royalty revenues of life sciences products which serve as
                                                                                the collateral or other security for the repayment of obligations outstanding
                                                                                under the Company's investments. If a life sciences product is rendered
                                                                                obsolete or non-competitive by new products or improvements on existing
                                                                                products or governmental or regulatory action, such developments could have a
                                                                                material adverse effect on the ability of the borrower under the relevant debt
                                                                                asset to make payment of interest on, and repayments of the principal of, that
                                                                                debt asset, and consequently could adversely affect the Company's performance.
                                                                                If additional side effects or complications are discovered with respect to a
                                                                                life sciences product, and such life sciences product's market acceptance is
                                                                                impacted or it is withdrawn from the market, continuing payments of interest
                                                                                on, and repayment of the principal of, that debt asset may not be made on time
                                                                                or at all. It is possible that over time side effects or complications from
                                                                                one or more of the life sciences products could be discovered, and, if such a
                                                                                side effect or complication posed a serious safety concern, a life sciences
                                                                                product could be withdrawn from the market, which could adversely affect the
                                                                                ability of the borrower under the relevant debt asset to make continuing
                                                                                payments of interest on, and repayment of the principal of, that debt asset,
                                                                                in which case the Company's ability to make distributions to investors may be
                                                                                materially and adversely affected.

                                                                                Furthermore, if an additional side effect or complication is discovered that
                                                                                does not pose a serious safety concern, it could nevertheless negatively
                                                                                impact market acceptance and therefore result in decreased net sales of one or
                                                                                more of the life sciences products, which could adversely affect the ability
                                                                                of borrowers under the relevant debt asset(s) to make continuing payments of
                                                                                interest on, and repayment of the principal of, that debt asset(s), in which
                                                                                case the Company's ability to make distributions to investors may be
                                                                                materially and adversely affected.

                                                                                The Investment Manager engages in a thorough diligence process before entering
                                                                                into any debt instrument with the counterparty and interacts with each
                                                                                counterparty as needed to evaluate the status of its investment on an ongoing
                                                                                basis.

 Investments in debt obligations are subject to credit and interest rate risks  Debt instruments are subject to credit and interest rate risks. Credit risk
                                                                                refers to the likelihood that the borrower will default in the payment of
                                                                                principal and/or interest on an instrument. Financial strength and solvency of
                                                                                a borrower are the primary factors influencing credit risk. In addition, lack
                                                                                or inadequacy of collateral or credit enhancement for a debt asset may affect
                                                                                its credit risk. Credit risk may change over the life of an instrument.
                                                                                Interest rate risk refers to the risks associated with market changes in
                                                                                interest rates. Interest rate changes may affect the value of a debt asset
                                                                                indirectly (especially in the case of fixed rate debt assets) and directly
                                                                                (especially in the case of debt assets whose rates are adjustable). In
                                                                                general, rising interest rates will negatively impact the price of a fixed
                                                                                rate debt asset and falling interest rates will have a positive effect on
                                                                                price. Adjustable rate instruments also react to interest rate changes in a
                                                                                similar manner although generally to a lesser degree (depending, however, on
                                                                                the characteristics of the reset terms, including the index chosen, frequency
                                                                                of reset and reset caps or floors, among other factors). Interest rate
                                                                                sensitivity is generally more pronounced and less predictable in instruments
                                                                                with uncertain payment or prepayment schedules. In addition, interest rate
                                                                                increases generally will increase the interest carrying costs to the Company
                                                                                (or any entity through which the Company invests) of leveraged investments.

                                                                                The Company will often seek to be a secured lender for each Debt Asset.
                                                                                However, there is no guarantee that the relevant borrower will repay the loan
                                                                                or that the collateral will be sufficient to satisfy the amount owed under the
                                                                                relevant Debt Asset. Credit risk will be assessed on an ongoing basis along
                                                                                with interest rate risk, and is further mitigated by the Company's investment
                                                                                policy permitting up to 25 per cent. of the Company's assets to be invested in
                                                                                a single Debt Asset or in Debt Assets issued to a single borrower. Interest
                                                                                rate risk can be managed in a variety of ways, including with the use of
                                                                                derivatives.

 Counterparty risk                                                              The Company intends to hold debt assets that will generate an interest
                                                                                payment. There is no guarantee that any borrower will honour their
                                                                                obligations. The default or insolvency of such borrowers may substantially
                                                                                affect the Company's business, financial condition, results of operations, the
                                                                                NAV and Shareholder returns.

                                                                                The Company will often seek to be a secured lender for each Debt Asset.
                                                                                However, there is no guarantee that the collateral will be sufficient to
                                                                                satisfy the amount owed under the relevant Debt Asset.

 Sales of life sciences products are subject to regulatory actions that could   There can be no assurance that any regulatory approvals for indications
 harm the Company's ability to make distributions to investors                  granted to one or more life sciences products will not be subsequently revoked

                                                                              or restricted. Such revocation or restriction may have a material adverse
                                                                                effect on the sales of such products and on the ability of borrowers under the
                                                                                relevant Debt Asset to make continuing payments of interest on, and repayment
                                                                                of the principal of, that Debt Asset, in which case the Company's ability to
                                                                                make distributions to investors may be materially and adversely affected.
                                                                                Changes in legislation are monitored with the use of third-party legal
                                                                                advisers and the Investment Manager will maintain awareness of new approvals
                                                                                or revoked approvals.

 Net asset values published will be estimates only and may differ materially    Generally, there will be no readily available market for a significant number
 from actual results                                                            of the Company's investments and hence, the majority of the Company's
                                                                                investments are not valued based on market- observable inputs.

                                                                                The valuations used to calculate the NAV on a monthly basis will be based on
                                                                                the Investment Manager's unaudited estimated fair market values of the
                                                                                Company's investments. It should be noted any such estimates may vary (in some
                                                                                cases materially) from the results published in the Company's financial
                                                                                statements (as the figures are published at different times) and that they,
                                                                                and any NAV figure published, may vary (in some cases materially) from
                                                                                realised or realisable values.

                                                                                The Investment Manager sends valuations on a monthly basis to the
                                                                                administrator for calculation of the NAV. The NAV is prepared by the
                                                                                administrator on the basis of information received from the Investment Manager
                                                                                and, once finalised, is reviewed and approved by a representative of the
                                                                                Investment Manager. Once approved, the Investment Manager notifies the Board
                                                                                and the NAV is released to the market.

 Changes in taxation legislation or practice may adversely affect the Company   Any change in the Company's tax status, or in taxation legislation or practice
 and the tax treatment for Shareholders investing in the Company                in the UK, US or elsewhere, could affect the value of the Company's
                                                                                investments and the Company's ability to achieve its investment objective, or
                                                                                alter the post-tax returns to Shareholders. It is the intention of the
                                                                                Directors to conduct the affairs of the Company so as to satisfy the
                                                                                conditions for approval of the Company by HMRC as an investment trust under
                                                                                section 1158 of the Corporation Tax Act 2010 (as amended) and pursuant to
                                                                                regulations made under Section 1159 of the Corporation Tax Act 2010. However,
                                                                                although the approval has been obtained, neither the Investment Manager nor
                                                                                the Directors can guarantee that this approval will be maintained at all
                                                                                times. The Company has been granted approval from HMRC as an investment trust
                                                                                and will continue to have investment trust status in each subsequent
                                                                                accounting period, unless the Company fails to meet the requirements to
                                                                                maintain investment trust status, pursuant to the regulations. For example, it
                                                                                is not possible to guarantee that the Company will remain a non-close company,
                                                                                which is a requirement to maintain investment trust status, as the Shares are
                                                                                freely transferable. Failure to maintain investment trust status could, as a
                                                                                result, (inter alia) lead to the Company being subject to UK tax on its
                                                                                chargeable gains. Existing and potential investors should consult their tax
                                                                                advisers with respect to their particular tax situations and the tax effects
                                                                                of an investment in the Company.

 Global pandemics may affect the operation and performance of the Company       Global pandemics have the potential to affect the daily operations of the
                                                                                Investment Manager and its service providers. The Company's Investment Manager
                                                                                and current service providers may rely on their business continuity plans for
                                                                                remote work and there is an increased risk of control deficiencies. The
                                                                                ultimate impact of a pandemic or a similar health epidemic is highly
                                                                                uncertain, subject to change and may affect the credit quality of the loans in
                                                                                the Company's portfolio.

 

GOING CONCERN

The Directors consider that it is appropriate to adopt the going concern basis
in preparing the financial statements. After making enquiries, and bearing in
mind the nature of the Company's business and assets, the Directors consider
that the Company has adequate resources to continue in operational existence
for the foreseeable future. In arriving at this conclusion, the Directors have
considered the liquidity of the portfolio and the Company's ability to meet
obligations as they fall due for a period of at least 12 months from the date
that these financial statements were approved.

 

VIABILITY STATEMENT

The Board has assessed the principal risks facing the Company over a five-year
period, including those that would threaten its business model, future
performance, solvency or liquidity. The five-year period was selected to align
with the average duration of the Company's existing investments. The Board has
developed a matrix of risks facing the Company and has put in place certain
investment restrictions which are in line with the Company's investment
objective and policy in order to mitigate these risks as far as practicable.
The principal risks which have been identified, and the steps taken by the
Board to mitigate these risks, are presented above.

 

The Company believes its borrowing capabilities provide further flexibility
and help ensure it is in a position to finance its funding obligations in the
event that internally generated cash flow in the period is insufficient to
finance the unfunded portion of a lending commitment. The Board reviews the
Company's financing arrangements quarterly to ensure that the Company is in a
strong position to fund all outstanding commitments on existing investments as
well as being able to finance new investments. In addition, the Board
regularly reviews the prospects for the Company's portfolio and the pipeline
of potential investment opportunities which provide comfort that the Company
is able to continue to finance its activities for the medium-term future.

 

Based on this assessment, the Directors have a reasonable expectation that the
Company will be able to continue in operation and meet its liabilities as they
fall due over the next five-year period

 

ENVIRONMENTAL, HUMAN RIGHTS, EMPLOYEE, SOCIAL AND COMMUNITY ISSUES

The Board recognises the requirement under the Companies Act 2006 to detail
information about employees, human rights, environmental and community issues,
including information about any policies it has in relation to these matters
and the effectiveness of these policies. These requirements do not apply
directly to the Company as it has no employees, all the Directors are
non-executive and it has outsourced all its functions to third-party service
providers. The Company has therefore not reported further in respect of these
provisions.

While the Company is not within the scope of the Modern Slavery Act 2015 and
it is not, therefore, obliged to make a slavery and human trafficking
statement, the Company considers its supply chains to be of low risk as its
principal service providers are the professional advisers set out in the
Corporate Information section below. Further information on the Company's
anti-bribery and corruption policy is set out in the full Annual Report.

There are six Directors, four male and two female. Further information on the
composition and operation of the Board is detailed in the full Annual Report.

 

This Strategic Report has been approved by the Board and signed on its behalf
by

 

 

Harry Hyman

Chairman

26 March 2024

 

EXTRACTS FROM THE DIRECTORS' REPORT

 

The Directors are pleased to present the Annual Report and audited financial
statements for the year ended 31 December 2023.

 

Directors

The Directors of the Company who were in office during the year and up to the
date of signing the financial statements are listed below:

 

Harry Hyman - Chairman

Duncan Budge - Senior Independent Director

Colin Bond - Chairman of the Audit and Risk Committee

Stephanie Léouzon - Director

Rolf Soderstrom - Director

Sapna Shah - Director (appointed 22 March 2023)

 

Share capital

 

An allotment authority for the issuance of up to 131,865,488 ordinary or C
shares was passed at the Company's Annual General Meeting held on 30 May 2023.
This authority will expire at the conclusion of, and renewal will be sought
at, the annual general meeting to be held on 12 June 2024. No shares were
issued during the year.

At the Annual General Meeting held on 30 May 2023, the Company was granted
authority to purchase up to 14.99 per cent. of the Company's Ordinary Share
capital in issue at that date, amounting to 205,952,416 Ordinary Shares. This
authority will expire at the conclusion of, and renewal will be sought at, the
Annual General Meeting to be held in June 2024. No shares were purchased for
cancellation during the year.

As set out in the Chairman's Statement above, during the year, the Company's
discount control mechanism was triggered and the Company was required to use
its capital to repurchase shares. During 2023, 16,499,477 shares of $0.01 were
bought back at a total cost of $15,162,792 and are held in treasury. This
represented 1.2 per cent. of the issued share capital as at 31 December 2023.
No shares were purchased for cancellation.

At 31 December 2023, and as at the date of this report, there are
1,373,932,067 Ordinary Shares in issue. As at 31 December 2023 there were
71,252,875 Ordinary Shares held in treasury. Since 31 December 2023, a further
49,041,347 shares have been repurchased and the total number of shares held in
treasury is 120,294,222. At general meetings of the Company, shareholders are
entitled to one vote on a show of hands and on a poll, to one vote for every
Share held. Shares held in treasury do not carry voting rights. The total
voting rights of the Company at 31 December 2023 was 1,302,679,192 and as at
the date of this report 1,253,637,845.

 
Further information on the Company's share capital is set out in Note 13 to
the financial statements.

 

STATEMENT OF DIRECTORS' RESPONSIBILITIES

In respect of the financial statements

 

The directors are responsible for preparing the Annual Report and the
financial statements in accordance with applicable law and regulation.

Company law requires the directors to prepare financial statements for each
financial year. Under that law the directors have prepared the financial
statements in accordance with UK adopted International Accounting Standards
("UK IAS").

Under company law, directors must not approve the financial statements unless
they are satisfied that they give a true and fair view of the state of affairs
of the Company and of the profit or loss of the company for that period. In
preparing the financial statements, the directors are required to:

·          select suitable accounting policies and then apply them
consistently;

·          state whether applicable UK IASs have been followed,
subject to any material departures disclosed and explained in the financial
statements;

·          make judgements and accounting estimates that are
reasonable and prudent; and

·          prepare the financial statements on the going concern
basis unless it is inappropriate to presume that the company will continue in
business.

 

The directors are also responsible for safeguarding the assets of the company
and hence for taking reasonable steps for the prevention and detection of
fraud and other irregularities.

The directors are responsible for keeping adequate accounting records that are
sufficient to show and explain the Company's transactions and disclose with
reasonable accuracy at any time the financial position of the company and
enable them to ensure that the financial statements and the Directors'
Remuneration Report comply with the Companies Act 2006.The directors are
responsible for the maintenance and integrity of the Company's website.
Legislation in the United Kingdom governing the preparation and dissemination
of financial statements may differ from legislation in other jurisdictions.

 

DIRECTORS' CONFIRMATIONS

The Directors consider that the Annual Report and accounts, taken as a whole,
are fair, balanced and understandable and provide the information necessary
for shareholders to assess the Company's position and performance, business
model and strategy.

Each of the directors, whose names and functions are listed in the Board of
Directors above confirm that, to the best of their knowledge:

·      the company financial statements, which have been prepared in
accordance with UK IASs, give a true and fair view of the assets, liabilities,
financial position and profit of the Company; and

·      the Strategic Report includes a fair review of the development
and performance of the business and the position of the company, together with
a description of the principal risks and uncertainties that it faces.

On behalf of the Board

 

Harry Hyman

Chairman

26 March 2024

 

CORPORATE INFORMATION

 

Directors

Harry Hyman (Chairman)

Colin Bond

Duncan Budge

Stephanie Léouzon

Rolf Soderstrom

Sapna Shah

 

Investment Manager and AIFM

Pharmakon Advisors L.P.

110 East 59th Street #2800

New York, NY 10022

USA

 

Administrator

Link Alternative Fund Administrators Limited

Boardwalk House

Southernhay West

Exeter

EX1 1TS

 

Company Secretary and Registered Office

Link Company Matters Limited

6(th) Floor

65 Gresham Street

London

EC2V 7NQ

 

Company Website

www.bpcruk.com (http://www.bpcruk.com)

 

Custodian

Bank of New York Mellon

One Canada Square

London

E14 5AL

 

Financial and Strategic Communications

Buchanan Communications Limited

107 Cheapside

London

EC2V 6DN

 

Independent Auditor

Ernst & Young  LLP, Chartered Accountants

Harcourt Centre

Harcourt Street

Dublin 2 Ireland

 

Joint Brokers

J.P. Morgan Cazenove

25 Bank Street

London

E14 5JP

 

Goldman Sachs International

Peterborough Court

133 Fleet Street

London

EC4A 2BB

 

Legal Adviser

Herbert Smith Freehills LLP

Exchange House

Primrose Street

London

EC2A 2EG

 

Registrar

Link Group

Central Square

29 Wellington Street

Leeds

LS1 4DL

 

 

 

 

SHAREHOLDER INFORMATION

 

Key dates

 

 March      Annual results announced

            Payment of fourth interim dividend

 June       Company's half-year end

            Payment of first interim dividend

            Annual General Meeting

 September  Half-yearly results announced

            Payment of second interim dividend

 December   Company's year end

            Payment of third interim dividend

 

Frequency of NAV publication

The Company's NAV is released to the LSE on a monthly basis and is published
on the Company's website.

 

Annual and Half-yearly report

Copies of the Company's Annual and Half-yearly Reports, stock exchange
announcements and further information on the Company can be obtained from the
Company's website www.bpcruk.com.

 

Identification codes

SEDOL:            BDGKMY2

ISIN:                 GB00BDGKMY29

TICKER:            BPCR

LEI:                  213800AV55PYXAS7SY24

 

Contacting the Company

Shareholder queries are welcomed by the Company. While any queries regarding
your shareholding should be directed to the Registrar, shareholders who wish
to raise any other matters with the Company may do so using the following
contact details:

 

Company Secretary - biopharmacreditplc@linkgroup.co.uk

 

Chairman - chairman@bpcruk.com

 

Senior Independent Director - sid@bpcruk.com

 

END

 

 

Neither the contents of the Company's website nor the contents of any website
accessible from hyperlinks on this announcement (or any other website) is
incorporated into, or forms part of, this announcement.

 

 

 

 

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