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REG - Burning Rock Biotech - Burning Rock Third Quarter 2022 Financial Results

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RNS Number : 5568G  Burning Rock Biotech Limited  16 November 2022

Burning Rock Reports Third Quarter 2022 Financial Results

GUANGZHOU, China, November 16, 2022-Burning Rock Biotech Limited (NASDAQ: BNR
and LSE: BNR, the "Company" or "Burning Rock"), a company focused on the
application of next generation sequencing (NGS) technology in the field of
precision oncology, today reported financial results for the three months
ended September 30, 2022.

 

Recent Business Updates

·         Corporate

o  Listed on the Main Market of the London Stock Exchange (the "LSE") by way
of a direct listing on November 1, 2022, while Burning Rock's ADSs will
continue to be listed and traded on the Nasdaq Global Market, with those ADSs
being fully fungible with the ADSs listed on the LSE.

·         Therapy Selection and Minimal Residual Disease (MRD)

o  In-hospital strategy continues to drive growth uplift despite negative
Covid impact. In-hospital volumes grew 24% year-over-year in the third quarter
of 2022.

o  MRD volumes continue to ramp up following commercial launch in March 2022,
with approximately 700 tests completed in the third quarter of 2022, more than
doubling the volumes in the second quarter of 2022.

·        Early Detection

o  PROMISE study (2,035 participants) for 9-cancer test results presented at
European Society for Medical Oncology (ESMO) Congress 2022 in September 2022.
Overall sensitivity achieved 83.7% for 9 cancers at specificity of 98.3%, with
methylation contributing majority of positive detections compared to protein
and mutation. Tissue origin prediction accuracy achieved 90.9% for the top 2
organs.

o  Commercialization of our blood-based, 6-cancer early detection test
gaining initial traction, with  product onboarding completed at a few
hospitals.

·         Pharma Services

o  The total value of new contracts we entered into from January to September
2022 amounted to RMB198 million, representing approximately 38% increase from
the same period of 2021.

o  Starting to work with BeiGene on initial clinical studies using our
personalized MRD test brPROPHET(TM) .

o  New companion diagnostics (CDx) development announced with Eli Lilly and
Company in China, for the RET inhibitor selpercatinib.

 

Third Quarter 2022 Financial Results

Revenues were RMB154.6 million (US$21.7 million) for the three months ended
September 30, 2022, representing a 22.1% increase from RMB126.6 million for
the same period in 2021.

·      Revenue generated from central laboratory business was RMB90.0
million (US$12.7 million) for the three months ended September 30, 2022,
representing a 14.2% increase from RMB78.8 million for the same period in
2021, driven by revenue increase from monitoring packages that consist of
multiple tests per package.

·      Revenue generated from in-hospital business was RMB49.6 million
(US$7.0 million) for the three months ended September 30, 2022, representing a
13.5% increase from RMB43.7 million for the same period in 2021, primarily
attributable to in-hosiptal sales volume growth in Shanghai and Beijing as
COVID impact lessened in the third quarter of 2022.

·      Revenue generated from pharma research and development services
was RMB15.0 million (US$2.1 million) for the three months ended September 30,
2022, representing a 267.4% increase from RMB4.1 million for the same period
in 2021, primarily attributable to increased development and testing services
performed for our pharma customers.

Cost of revenues was RMB46.0 million (US$6.5 million) for the three months
ended September 30, 2022, representing a 31.5% increase from RMB35.0 million
for the same period in 2021, primarily due to an increase in testing and
selling volume as well as rental expense and renovation depreciation in
relation to our new laboratory that commenced use in January 2022.

Gross profit was RMB108.6 million (US$15.3 million) for the three months ended
September 30, 2022, representing a 18.6% increase from RMB91.6 million for the
same period in 2021. Gross margin was 70.2% for the three months ended
September 30, 2022, which decreased from 72.3% for the same period in 2021,
primarily due to an increased income from monitoring packages, offset by an
increased depreciation in relation to our new laboratory.

Non-GAAP gross profit, which excludes depreciation and amortization expenses,
was RMB117.0 million (US$16.4 million) for the three months ended September
30, 2022, representing a 25.8% increase from RMB93.0 million for the same
period in 2021. Non-GAAP gross margin was 75.7% for the three months ended
September 30, 2022, compared to 73.4% for the same period in 2021.

Operating expenses were RMB343.2 million (US$48.3 million) for the three
months ended September 30, 2022, representing a 30.7% increase from RMB262.6
million for the same period in 2021.

·        Research and development expenses were RMB109.4 million
(US$15.4 million) for the three months ended September 30, 2022, representing
a 57.2% increase from RMB69.6 million for the same period in 2021, primarily
due to (i) an increase in clinical program expenses for early cancer
detection; and (ii) an increase in amortized expense on share-based
compensation, offset in part by a decrease in staff cost due to organizational
restructuring.

·         Selling and marketing expenses were RMB90.3 million
(US$12.7 million) for the three months ended September 30, 2022, representing
a 17.7% increase from RMB76.7 million for the same period in 2021, primarily
due to (i) an increase in staff cost resulted from increase in headcount; (ii)
an increase in conference fee and (iii) an increase amortized expense on
share-based compensation. Sequentially, selling and marketing expenses in the
third quarter decreased by 14.5% compared to the second quarter of 2022, as
our sales reorganization and operating efficiency improvement initiative
started to generate initial results. We will continue to focus on improving
operating efficiency going forward.

·        General and administrative expenses were RMB143.5 million
(US$20.2 million) for the three months ended September 30, 2022, representing
a 23.4% increase from RMB116.3 million for the same period in 2021, primarily
due to (i) an increase in depreciation expenses for a new building; (ii) an
increase in allowance for credit loss in relation to accounts receivables; and
(iii) an increase amortized expense on share-based compensation.

Net loss was RMB231.5 million (US$32.5 million) for the three months ended
September 30, 2022, compared to RMB170.5 million for the same period in 2021.

Net cash used in operating activities was RMB135.5 million (US$19.0 million)
for the three months ended September 30, 2022, compared to RMB133.4 million
for the same period in 2021. The balance of cash, cash equivalents, restricted
cash and short-term investments was RMB1,014.0 million (US$142.5 million) as
of September 30, 2022.

 

Revised 2022 Financial Guidance

We believe that we have achieved strong, above-industry growth in the first
nine months of 2022, generating revenues of RMB421 million, an increase of 17%
compared to the same period of 2021. This is below the implied full-year
growth rate of our initial guidance at the beginning of the year, primarily
due to an out-sized Covid impact in Shanghai in the second quarter and to a
lesser extent, Covid-related disruptions in other regions of China from time
to time. We have observed another significant wave of Covid cases sweeping
through many large cities in China since the start of October, particularly in
Guangzhou, which is one of our key markets and where our central lab is
located. We are taking a cautious view now and project a drop in revenues in
the fourth quarter compard to the same period last year, which was a strong
quarter and relatively free of large Covid impacts. We therefore revise our
2022 full-year revenue guidance to a growth of approxiately 5% compared to
2021.

 

 

 

Transition of Chief Operating Officer to Chief Scientific Officer

Effective November 2022, Shannon Chuai, our chief operating officer, is taking
on a new role of chief scientific officer of Burning Rock. In her new role,
Shannon will lead key projects of our pipeline development, provide senior
oversight on our early cancer detection clinical programs and our engagement
on product registration with the NMPA and other medical regulatory bodies.
Shannon continues to serve as a director on our board. The company's
respective business units will report directly to our CEO, Yusheng Han.

 

Conference Call Information

Burning Rock will host a conference call to discuss the third quarter 2022
financial results at 8:30 a.m. U.S. Eastern Time (9:30 p.m. Hong Kong time) on
November 16, 2022.

Please register in advance of the conference using the link provided below and
dial in 15 minutes prior to the call, using participant dial-in numbers and
unique registrant ID which would be provided upon registering.

PRE-REGISTER LINK:
https://register.vevent.com/register/BI96c581babaf44021ab6c34af9f7ce42b
(https://register.vevent.com/register/BI96c581babaf44021ab6c34af9f7ce42b) .

Additionally, a live and archived webcast of the conference call will also be
available on the company's investor relations website at
http://ir.brbiotech.com (http://ir.brbiotech.com) or through link
https://edge.media-server.com/mmc/p/8fj2edsi
(https://edge.media-server.com/mmc/p/8fj2edsi) .

A replay of the webcast will be available for 12 months via the same link
above.

 

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR; LSE: BNR), whose mission is to
guard life via science, focuses on the application of next generation
sequencing (NGS) technology in the field of precision oncology. Its business
consists of i) NGS-based therapy selection testing for late-stage cancer
patients, and ii) cancer early detection, which has moved beyond
proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

 

Safe Harbor Statement

This press release contains forward-looking statements. These statements
constitute "forward-looking" statements within the meaning of Section 21E of
the Securities Exchange Act of 1934, as amended, and as defined in the U.S.
Private Securities Litigation Reform Act of 1995. These forward-looking
statements can be identified by terminology such as "will," "expects,"
"anticipates," "future," "intends," "plans," "believes," "estimates,"
"target," "confident" and similar statements. Burning Rock may also make
written or oral forward-looking statements in its periodic reports to the SEC,
in its annual report to shareholders, in press releases and other written
materials and in oral statements made by its officers, directors or employees
to third parties. Statements that are not historical facts, including
statements about Burning Rock's beliefs and expectations, are forward-looking
statements. Such statements are based upon management's current expectations
and current market and operating conditions, and relate to events that involve
known or unknown risks, uncertainties and other factors, all of which are
difficult to predict and many of which are beyond Burning Rock's control.
Forward-looking statements involve risks, uncertainties and other factors that
could cause actual results to differ materially from those contained in any
such statements. All information provided in this press release is as of the
date of this press release, and Burning Rock does not undertake any obligation
to update any forward-looking statement as a result of new information, future
events or otherwise, except as required under applicable law.

 

Non-GAAP Measures

In evaluating the business, the company considers and uses non-GAAP measures,
such as non-GAAP gross profit and non-GAAP gross margin, as supplemental
measures to review and assess operating performance. The presentation of these
non-GAAP financial measures is not intended to be considered in isolation or
as a substitute for the financial information prepared and presented in
accordance with accounting principles generally accepted in the United States
of America ("U.S. GAAP"). The company defines non-GAAP gross profit as gross
profit excluding depreciation and amortization. The company defines non-GAAP
gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used
by management to evaluate operating performance and formulate business plans.
The company believe non-GAAP gross profit and non-GAAP gross margin excluding
non-cash impact of depreciation and amortization reflect the company's ongoing
business operations in a manner that allows more meaningful period-to-period
comparisons.

 

Contact: IR@brbiotech.com

Selected Operating Data

 

                                                     For the three months ended
                                     March 31, 2021  June 30,  September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022

                                                     2021                          2021
 Central Laboratory Channel:
 Number of patients tested           7,716           8,155     7,808               8,235          7,743          8,060          7,989

                                                      1,013

                                                      300
 Number of ordering physicians((1))  1,082           1,013     920                 917           994             767            897
 Number of ordering hospitals((2))   303             300       287                 306           318             264            257

 

 

 ((1))    Represents physicians who on average order at least one test from us every
          month during a relevant period in the central laboratory channel.
 ((2))    Represents hospitals whose residing physicians who on average order at least
          one test from us every month during a relevant period in the central
          laboratory channel.

                                   As of
                             March 31, 2021  June 30,  September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022

                                     2021                          2021
          In-hospital Channel:
          Pipeline partner hospitals((1))      22              22        24                  23            24              25             22
          Contracted partner hospitals((2))    32              34        34                  41            41              43             47
          Total number of partner hospitals    54              56        58                  64            65              68             69

 

 ((1))    Refers to hospitals that are in the process of establishing in-hospital
          laboratories, laboratory equipment procurement or installation, staff training
          or pilot testing using the Company's products.
 ((2))    Refers to hospitals that have entered into contracts to purchase the Company's
          products for use on a recurring basis in their respective in-hospital
          laboratories the Company helped them establish. Kit revenue is generated from
          contracted hospitals.

 

 

((1))

Refers to hospitals that are in the process of establishing in-hospital
laboratories, laboratory equipment procurement or installation, staff training
or pilot testing using the Company's products.

((2))

Refers to hospitals that have entered into contracts to purchase the Company's
products for use on a recurring basis in their respective in-hospital
laboratories the Company helped them establish. Kit revenue is generated from
contracted hospitals.

 

 

Selected Financial Data

 

                                                     For the three months ended
 Revenues                                 March 31,  June 30,  September 30, 2021  December   March 31, 2022  June 30, 2022  September 30, 2022

                                          2021       2021                          31, 2021

                                          (RMB in thousands)
 Central laboratory channel               74,561     79,999    78,817              85,976     74,211           78,597        89,992
 In-hospital channel                      28,994     40,502    43,714              51,906     48,957           34,177        49,636
 Pharma research and development channel  3,068      6,778     4,084               9,463      12,356           18,072        15,003
 Total revenues                           106,623    127,279   126,615             147,345    135,524          130,846       154,631

 

 

                                                     For the three months ended
 Gross profit                             March 31,  June 30,  September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022

                                          2021       2021                          2021

                                          (RMB in thousands)
 Central laboratory channel               55,212     58,681    58,387              65,985         50,574         57,575         69,991
 In-hospital channel                      20,070     29,426    31,111              34,194         33,396         20,012         31,593
 Pharma research and development channel  1,658      2,124     2,098               5,200          3,610          5,015          7,010
 Total gross profit                       76,940     90,231    91,596              105,379        87,580         82,602         108,594

 

 

 

                                                     For the three months ended
 Share-based compensation expenses        March 31,  June 30,  September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022

                                          2021       2021                          2021

                                          (RMB in thousands)
 Cost of revenues                         339        406       267                 492            365             441           481
 Research and development expenses        22,404     20,825    (9,559)             (4,033)        12,299          11,923        13,978
 Selling and marketing expenses           2,633      2,809     2,044               2,126          1,774           2,158         2,346
 General and administrative expenses      59,382     59,369    60,803              62,126         65,715          62,615        61,041
 Total share-based compensation expenses  84,758     83,409    53,555              60,711        80,153          77,137         77,846

 

 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

 (in thousands, except for number of shares and per share data)

                                                                          For the three months ended
                                                                          March 31,   June 30,    September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022  September 30, 2022

                                                                          2021        2021                            2021
                                                                          RMB         RMB         RMB                 RMB           RMB             RMB            RMB                 US$
 Revenues                                                                 106,623     127,279     126,615             147,345       135,524         130,846        154,631             21,738
 Cost of revenues                                                         (29,683)    (37,048)    (35,019)            (41,966)      (47,944)        (48,244)       (46,037)            (6,471)
 Gross profit                                                             76,940      90,231      91,596              105,379       87,580          82,602         108,594             15,267
 Operating expenses:
 Research and development expenses                                        (77,414)    (108,071)   (69,649)            (112,724)      (119,496)      (92,112)       (109,433)           (15,384)
 Selling and marketing expenses                                           (55,130)    (68,058)     (76,687)           (103,221)      (89,211)        (105,634)       (90,275)          (12,691)
 General and administrative expenses                                      (116,259)   (116,130)    (116,304)          (141,563)      (141,733)      (150,316)      (143,530)           (20,177)
 Total operating expenses                                                 (248,803)   (292,259)   (262,640)           (357,508)     (350,440)       (348,062)      (343,238)           (48,252)
 Loss from operations                                                     (171,863)   (202,028)   (171,044)           (252,129)     (262,860)       (265,460)      (234,644)           (32,985)
 Interest income                                                          787         681         958                 1,031          1,832           2,685           2,001             281
 Interest expenses                                                        (510)       (565)       (367)               (94)           119             (29)            12                2
 Other income (expense), net                                              118         433         20                  (372)          298             127             (189)             (27)
 Foreign exchange gain (loss), net                                        57          (560)       380                 (731)          (777)           624              1,337            188
 Loss before income tax                                                   (171,411)   (202,039)   (170,053)           (252,295)     (261,388)       (262,053)      (231,483)           (32,541)
 Income tax (expenses) benefits                                           -           (1,626)     (424)               1,151         -               (84)           -                   -
 Net loss                                                                 (171,411)   (203,665)   (170,477)           (251,144)     (261,388)       (262,137)      (231,483)           (32,541)
 Net loss attributable to Burning Rock Biotech Limited's shareholders     (171,411)   (203,665)   (170,477)           (251,144)     (261,388)       (262,137)      (231,483)

                                                                                                                                                                                       (32,541)
 Net loss attributable to ordinary shareholders                           (171,411)   (203,665)   (170,477)           (251,144)     (261,388)       (262,137)      (231,483)

                                                                                                                                                                                       (32,541)
 Loss per share for class A and class B ordinary shares:
 Class A ordinary shares - basic and diluted                              (1.65)      (1.96)       (1.64)             (2.40)        (2.50)          (2.50)         (2.23)              (0.31)
 Class B ordinary shares - basic and diluted                              (1.65)      (1.96)       (1.64)             (2.40)        (2.50)          (2.50)         (2.23)              (0.31)
 Weighted average shares outstanding used in loss per share computation:
 Class A ordinary shares - basic and diluted                              86,721,263  86,764,260  86,908,975          87,128,297    87,179,752      87,532,539      86,585,322          86,585,322
 Class B ordinary shares - basic and diluted                              17,324,848  17,324,848  17,324,848          17,324,848    17,324,848      17,324,848     17,324,848          17,324,848
 Other comprehensive income (loss), net of tax of nil:
 Foreign currency translation adjustments                                 14,080      (34,980)    6,146               (24,726)      (3,065)         29,715         20,646              2,902
 Total comprehensive loss                                                 (157,331)   (238,645)   (164,331)           (275,870)     (264,453)       (232,422)      (210,837)           (29,639)
 Total comprehensive loss attributable to Burning Rock Biotech Limited's  (157,331)   (238,645)   (164,331)           (275,870)     (264,453)       (232,422)      (210,837)           (29,639)
 shareholders

 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

 (in thousands, except for number of shares and per share data)

 

                                                                          For the nine months ended
                                                                          September 30,  September 30,  September 30,

                                                                          2021           2022           2022
                                                                          RMB            RMB            US$
 Revenues                                                                 360,517        421,001        59,183
 Cost of revenues                                                         (101,750)      (142,225)      (19,993)
 Gross profit                                                             258,767        278,776        39,190
 Operating expenses:
 Research and development expenses                                        (255,134)      (321,041)      (45,131)
 Selling and marketing expenses                                           (199,875)        (285,120)      (40,082)
 General and administrative expenses                                        (348,693)    (435,579)      (61,233)
 Total operating expenses                                                 (803,702)      (1,041,740)    (146,446)
 Loss from operations                                                     (544,935)      (762,964)      (107,256)
 Interest income                                                            2,426          6,518          916
 Interest expenses                                                          (1,442)        102           14
 Other income, net                                                          571            236            33
 Foreign exchange loss, net                                                 (123)          1,184           166
 Loss before income tax                                                   (543,503)      (754,924)      (106,127)
 Income tax expenses                                                      (2,050)        (84)           (12)
 Net loss                                                                 (545,553)      (755,008)      (106,139)
 Net loss attributable to Burning Rock Biotech Limited's shareholders     (545,553)      (755,008)      (106,139)
 Net loss attributable to ordinary shareholders                           (545,553)      (755,008)      (106,139)
 Loss per share for class A and class B ordinary shares:
 Class A ordinary shares - basic and diluted                               (5.24)        (7.23)         (1.02)
 Class B ordinary shares - basic and diluted                               (5.24)        (7.23)         (1.02)
 Weighted average shares outstanding used in loss per share computation:
 Class A ordinary shares - basic and diluted                              86,798,854      87,097,027     87,097,027
 Class B ordinary shares - basic and diluted                              17,324,848     17,324,848     17,324,848
 Other comprehensive income (loss), net of tax of nil:
 Foreign currency translation adjustments                                 (14,754)       47,296         6,649
 Total comprehensive loss                                                 (560,307)      (707,712)      (99,490)
 Total comprehensive loss attributable to Burning Rock Biotech Limited's  (560,307)      (707,712)      (99,490)
 shareholders

 

 

 

 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

                                            As of
                                            December 31, 2021  September 30,     September 30,

                                                               2022              2022
                                            RMB                RMB               US$
 ASSETS
 Current assets:
 Cash and cash equivalents                  1,431,317            1,009,790         141,954
 Restricted cash                            7,795                4,216             593
 Short-term investments                     63,757              -                -
 Accounts receivable, net                   92,197               102,385         14,393
 Contract assets, net                       42,391               46,591            6,550
 Inventories, net                           123,210              150,428           21,147
 Prepayments and other current assets, net  60,279               41,220            5,794
 Total current assets                        1,820,946           1,354,630         190,431
 Non-current assets:
 Equity method investment                   910                  644               91
 Convertible note receivable                -                  5,000             703
 Property and equipment, net                325,438              288,499         40,556
 Operating right-of-use assets              81,007             58,379            8,207
 Intangible assets, net                     5,150                2,774             390
 Other non-current assets                   45,136             21,369              3,004
 Total non-current assets                   457,641            376,665           52,951
 TOTAL ASSETS                                2,278,587         1,731,295         243,382

 

 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

                                                     As of
                                                     December 31, 2021  September 30,      September 30,

                                                                        2022               2022
                                                     RMB                RMB                US$
 LIABILITIES AND SHAREHOLDERS' EQUITY
 Current liabilities:
 Accounts payable                                    63,080                71,045            9,988
 Deferred revenue                                    142,871             168,260            23,654
 Accrued liabilities and other current liabilities   127,892             82,512             11,600
 Customer deposits                                   972                403                 57
 Short-term borrowing                                2,370              -                  -
 Current portion of operating lease liabilities      34,999              38,632             5,431
 Other current liabilities                           -                  2,557              359
 Total current liabilities                           372,184             363,409            51,089
 Non-current liabilities:
 Non-current portion of operating lease liabilities  49,316             22,865              3,214
 Other non-current liabilities                       11,776             46,079              6,478
 Total non-current liabilities                       61,092              68,944             9,692
 TOTAL LIABILITIES                                   433,276             432,353            60,781

 Shareholders' equity:
 Class A ordinary shares                             116                117                 16
 Class B ordinary shares                             21                 21                  3
 Additional paid-in capital                          4,280,956          4,499,491            632,528
 Treasury stock                                      -                  (57,193)           (8,040)
 Accumulated deficits                                (2,228,713)        (2,983,721)         (419,445)
 Accumulated other comprehensive loss                (207,069)          (159,773)           (22,461)
 Total shareholders' equity                          1,845,311          1,298,942          182,601
 TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY          2,278,587          1,731,295          243,382

 

 

 

 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

                                                                        For the three months ended
                                                                        September 30, 2021  September 30, 2022      September 30, 2022
                                                                        RMB                 RMB                     US$
 Net cash used in operating activities                                  (133,394)           (135,467)               (19,042)
 Net cash used in investing activities                                  (72,085)            (20,148)                (2,832)
 Net cash used in financing activities                                  (32,995)            (2,671)                 (375)
 Effect of exchange rate on cash, cash equivalents and restricted cash  4,919               19,242                  2,703
 Net decrease in cash, cash equivalents and restricted cash             (233,555)           (139,044)               (19,546)
 Cash, cash equivalents and restricted cash at the beginning of period  1,883,265           1,153,050               162,093
 Cash, cash equivalents and restricted cash at the end of period        1,649,710           1,014,006               142,547

 

 

                                                                        For the nine months ended
                                                                        September 30, 2021  September 30, 2022  September 30, 2022
                                                                        RMB                 RMB                 US$
 Net cash used in operating activities                                  (365,537)           (389,101)           (54,700)
 Net cash generated from (used in) investing activities                 148,667             (2,430)             (339)
 Net cash used in financing activities                                  (46,118)            (76,164)            (10,707)
 Effect of exchange rate on cash, cash equivalents and restricted cash  (12,508)            42,589              5,986
 Net decrease in cash, cash equivalents and restricted cash             (275,496)           (425,106)           (59,760)
 Cash, cash equivalents and restricted cash at the beginning of period  1,925,206           1,439,112           202,307
 Cash, cash equivalents and restricted cash at the end of period        1,649,710           1,014,006           142,547

 

 

 

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

 

                                                                              For the three months ended
                                                                   March 31,  June 30,  September 30, 2021  December 31,  March 31, 2022  June 30, 2022  September 30, 2022

                                                                   2021       2021                          2021
                                                                              (RMB in thousands)
 Gross profit:

 Central laboratory channel                                        55,212     58,681    58,387              65,985         50,574          57,575        69,991
 In-hospital channel                                               20,070     29,426    31,111              34,194         33,396          20,012        31,593
 Pharma research and development channel                           1,658      2,124     2,098               5,200          3,610           5,015         7,010
 Total gross profit                                                76,940     90,231    91,596              105,379        87,580         82,602         108,594

 Add: depreciation and amortization:
 Central laboratory channel                                         117        284       1,254               995           2,553           2,545         3,138
 In-hospital channel                                                79         113       109                 130           93              1,428         2,479
 Pharma research and development channel                            10         40        19                  856           2,493           4,327         2,805
 Total depreciation and amortization included in cost of revenues   206        437       1,382               1,981         5,139           8,300         8,422

 Non-GAAP gross profit:
 Central laboratory channel                                         55,329     58,965    59,641              66,980        53,127          60,120        73,129
 In-hospital channel                                                20,149     29,539    31,220              34,324        33,489          21,440        34,072
 Pharma research and development channel                            1,668      2,164     2,117               6,056         6,103           9,342         9,815
 Total non-GAAP gross profit                                        77,146     90,668    92,978              107,360       92,719         90,902         117,016
 Non-GAAP gross margin:
 Central laboratory channel                                        74.2%      73.7%     75.7%               77.9%         71.6%           76.5%          81.3%
 In-hospital channel                                               69.5%      72.9%     71.4%               66.1%         68.4%           62.7%          68.6%
 Pharma research and development channel                           54.4%      31.9%     51.8%               64.0%         49.4%           51.7%          65.4%
 Total non-GAAP gross margin                                       72.4%      71.2%     73.4%               72.9%         68.4%           69.5%          75.7%

 

 

 

 

 

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