** U.S.-listed shares of Centessa Pharmaceuticals 260y.F, CNTA.O rise 3.5% to $17.45
** Brokerage Leerink raises PT to $36 from $24, reiterates "outperform" rating
** CNTA shares offer tremendous upside potential because its orexin portfolio is targeting mega-blockbuster hypersomnia and excessive daytime sleepiness markets - brokerage
** Centessa has disclosed potency and selectivity for the orexin 2 receptor which appear to be "best-in-class" - Leerink
** Orexin receptor 2 is a protein in the brain that helps control sleep and wakefulness
** All nine brokerages, covering Centessa, rate the stock "buy" or higher; their median PT is $27, according to data compiled by LSEG
** CNTA more than doubled last year
(Reporting by Juby Babu in Mexico City)
((Juby.Babu@thomsonreuters.com;))