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CRVO — CervoMed News Story

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CervoMed rises as experimental drug shows benefit in early-stage dementia patients

** Shares of biotech firm CervoMed CRVO.O rise 8% to $4.58

** Co says new trial analysis shows its experimental drug neflamapimod worked best in people with early-stage dementia with Lewy bodies, a brain condition that affects memory, thinking and movement

** Says the disease worsened slower in patients with low pTau181 treated with neflamapimod, versus placebo; pTau181 is a blood marker linked to Alzheimer’s-related brain changes

** Neflamapimod is designed to reduce brain inflammation and nerve cell problems; higher drug levels in blood were linked to better clinical outcomes - CRVO

** Co plans to start a larger late-stage trial in the second half of 2026; says neflamapimod has been generally well tolerated across studies

** CRVO rose about three-fold in 2025

(Reporting by Sahil Pandey in Bengaluru)

((Sahil.Pandey@thomsonreuters.com))

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