** Brokerage TD Cowen says its investor survey shows that
sentiment of biotech companies is "as negative as ever",
suggesting that it likely can't get much worse
** Says mid-cap biotech firms are now clear favorites as
investors turn less constructive on large-caps and stay bearish
on small-cap biotechs
** Biotechs, hit by a funding crunch due to higher interest
rates, have reined in spending on drug development since the
start of the year
** The Nasdaq Biotechnology Index .NBI is down ~12% YTD,
while the wider Nasdaq composite index .IXIC has risen ~23%
this year
** The SPDR S&P Biotech ETF XBI.P is down ~20% this year,
set for its third straight year of decline
** Says 42% of respondents view mid-cap biotechs as
undervalued, up from just 13% in Q3
** Says shares of Moderna MRNA.O and CRISPR CRSP.O were
investors' pick for most likely to underperform among large and
mid-cap biotechs
** Overall for large drugmakers, 33% of investors now expect
them to underperform, up from just 13% in Q3, and only 25% (down
from 43%) expect that segment to outperform
(Reporting by Christy Santhosh)
((Christy.Santhosh@thomsonreuters.com))