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U.S. stock indexes struggled for direction on Wednesday after a strong start to
the week, as investors digested a fresh update on Pfizer and BioNTech's COVID-19
vaccine, while the fast-spreading Omicron variant kept bigger bets in check.
.N
At 14:08 ET, the Dow Jones Industrial Average .DJI was down 0.13% at
35,671.97. The S&P 500 .SPX was up 0.12% at 4,692.15 and the Nasdaq Composite
.IXIC was up 0.41% at 15,751.701.
The top three S&P 500 .PG.INX percentage gainers:
** Norwegian Cruise Line Holdings Ltd NCLH.N , up 8.7%
** Carnival Corp CCL.N , up 6.1%
** Royal Caribbean Cruises Ltd RCL.N , up 5.3%
The top three S&P 500 .PL.INX percentage losers:
** NXP Semiconductors NV NXPI.OQ , down 5.3%
** Kroger Co KR.N , down 4.4%
** Brown-Forman Corp BFb.N , down 3.2%
The top three NYSE .PG.N percentage gainers:
** RLX Technology Inc RLX.N , up 24.9%
** Bakkt Holdings Inc BKKT.N , up 21.3%
** Direxion Daily Travel & Vacation ETF OOTO.N , up 18.8%
The top three NYSE .PL.N percentage losers:
** Weave Communications Inc WEAV.N , down 16.4%
** Solo Brands Inc DTC.N , down 10.8%
** Albertsons Companies Inc ACI.N , down 9.7%
The top three Nasdaq .PG.O percentage gainers:
** Insignia Systems Inc ISIG.O , up 96.9%
** Energy Focus Inc EFOI.O , up 62.1%
** Aziyo Biologics Inc AZYO.O , up 26.1%
The top three Nasdaq .PL.O percentage losers:
** Radius Health Inc RDUS.O , down 44.3%
** Nuvei Corp NVEI.O , down 33.4%
** Cingulte Inc CING.O , down 31.5%
** AutoZone Inc AZO.N : down 1.9%
BUZZ-Street View: DIY trends to aid AutoZone sales urn:newsml:reuters.com:*:nL4N2ST3OL
** DocuSign DOCU.O : up 10.6%
BUZZ-Rebounds after CEO buys nearly $5 mln worth of stock urn:newsml:reuters.com:*:nL1N2ST1SB
** PerkinElmer Inc PKI.N : up 2.2%
BUZZ-Rises on launching sequencing kit to detect COVID variants urn:newsml:reuters.com:*:nL4N2ST3NQ
** Solo Brands Inc DTC.N : down 10.8%
BUZZ-Falls on profit miss; brokerage sees 'exceptional' long-term story
urn:newsml:reuters.com:*:nL4N2ST3NN
** GameStop Corp GME.N : down 1.0%
BUZZ-PREVIEW: GameStop wavers ahead of report urn:newsml:reuters.com:*:nL1N2ST1NZ
** Jefferies Financial Group JEF.N : down 1.7%
BUZZ- Falls as co cancels parties, travel due to COVID-19 urn:newsml:reuters.com:*:nL4N2ST3NB
** Meta Platforms Inc FB.O : up 2.4%
Apple Inc AAPL.O : up 1.9%
Netflix Inc NFLX.O : up 0.9%
BUZZ-Regulatory cloud on Chinese tech to help U.S. tech shine in 2022 -
Wedbush urn:newsml:reuters.com:*:nL4N2ST3MB
** Corcept Therapeutics Inc CORT.O : down 21.5%
BUZZ-Hits over 1-yr low on subpoena from New Jersey attorney office
urn:newsml:reuters.com:*:nL4N2ST3MK
** Datadog Inc DDOG.O : up 3.3%
BUZZ-Gains after Berenberg raises target price urn:newsml:reuters.com:*:nL4N2ST3K9
** Virpax Pharmaceuticals VRPX.O : up 7.1%
BUZZ-Rises after promising pre-clinical pain therapy data urn:newsml:reuters.com:*:nL4N2ST37G
** Lovesac Company LOVE.O : up 20.7%
BUZZ-Jumps on surprise profit as showroom sales soar urn:newsml:reuters.com:*:nL4N2ST3I8
** Prometheus Biosciences RXDX.O : up 3.2%
BUZZ-Soars to 6-month high as Oppenheimer upgrades stock urn:newsml:reuters.com:*:nL4N2ST3GF
** Confluent Inc CFLT.O : down 2.8%
BUZZ-Falls on plans to raise $1 bln urn:newsml:reuters.com:*:nL4N2ST3GH
** Nuvei Corp NVEI.O : down 33.4%
BUZZ-Share value halves on short-seller's "strong sell" report urn:newsml:reuters.com:*:nL4N2ST3CD
** Resolute Forest Products RFP.N : up 6.8%
BUZZ-Jumps on share buyback urn:newsml:reuters.com:*:nL4N2ST3FI
** Campbell Soup Co CPB.N : up 1.9%
BUZZ-Jumps on profit beat urn:newsml:reuters.com:*:nL4N2ST3FD
** Neurocrine Biosciences Inc NBIX.O : up 2.9%
BUZZ-Up on positive study data, PT raise urn:newsml:reuters.com:*:nL4N2ST3FB
** Roku Inc ROKU.O : up 18.3%
BUZZ-Up on multi-year deal with YouTube urn:newsml:reuters.com:*:nL4N2ST3DM
** Radius Health RDUS.O : down 44.3%
BUZZ-Crumbles on disappointing data from osteoporosis drug study urn:newsml:reuters.com:*:nL4N2ST3ET
** RLX Technology RLX.N : up 24.9%
BUZZ-Jumps on $500 mln share buyback plan urn:newsml:reuters.com:*:nL4N2ST3DT
** ChargePoint CHPT.N : down 3.1%
BUZZ-Falls after wider Q3 loss, brokerage cuts PT urn:newsml:reuters.com:*:nL4N2ST30U
** Affimed NV AFMD.O : up 6.0%
BUZZ-Rises on start of patient recruitment for cancer treatment study
urn:newsml:reuters.com:*:nL4N2ST3AR
** Palisade Bio PALI.O : up 7.9%
BUZZ-Rises on U.S. patent for lead drug urn:newsml:reuters.com:*:nL4N2ST358
** Verra Mobility VRRM.O : down 3.2%
BUZZ-Trips as Platinum Equity exits in secondary offering urn:newsml:reuters.com:*:nL1N2ST13A
** Hoth Therapeutics HOTH.O : up 7.4%
BUZZ-Rises on licensing autoimmune disease drug back to Zylo urn:newsml:reuters.com:*:nL4N2ST35M
** GT Biopharma GTBP.O : up 2.6%
BUZZ-Set for best day in over 3 months on tumor therapy trial update USN
** Photronics Inc PLAB.O : up 20.3%
BUZZ-Soars on upbeat Q4 results, forecast urn:newsml:reuters.com:*:nL4N2ST2PN
** EPAM Systems EPAM.N : up 14.6%
BUZZ-Set to hit 2-week high on S&P 500 inclusion urn:newsml:reuters.com:*:nL4N2ST2ZF
** Hilton Worldwide Holdings HLT.N : up 1.0%
Marriott International MAR.O : up 0.9%
Carnival Corp CCL.N : up 6.1%
Spirit Airlines SAVE.N : up 4.1%
Tripadvisor TRIP.O : up 2.6%
Norwegian Cruise Line Holdings NCLH.N : up 8.7%
Alaska Air Group ALK.N : up 2.7%
Melco Resorts & Entertainment Ltd MLCO.O : up 6.8%
BUZZ-Travel stocks rise on positive COVID-19 vaccine news from Pfizer
urn:newsml:reuters.com:*:nL4N2ST32I
** Stanley Black & Decker SWK.N : up 3.8%
BUZZ-Jumps on $3.2 bln electronic security business sale urn:newsml:reuters.com:*:nL4N2ST34Y
** TherapeuticsMD Inc TXMD.O : up 5.4%
BUZZ-Rises on patent litigation settlement with Amneal urn:newsml:reuters.com:*:nL4N2ST2Y2
** Lexaria Bioscience Corp LEXX.O : up 11.2%
BUZZ-Rises after cannabis-based formulation shows promising results in study
urn:newsml:reuters.com:*:nL4N2ST32W
** Goodyear Tire and Rubber GT.O : up 2.4%
BUZZ-Rises on Deutsche Bank upgrade urn:newsml:reuters.com:*:nL4N2ST30X
** Starwood Property Trust STWD.N : down 3.4%
BUZZ-Slips after pricing $397 mln stock offering urn:newsml:reuters.com:*:nL4N2ST2UT
** OPKO Health OPK.O : up 3.1%
BUZZ-Rises after U.S. FDA approves prostate cancer test urn:newsml:reuters.com:*:nL4N2ST309
** Wynn Resorts WYNN.O : up 2.3%
BUZZ-Appoints new CFO, shares up urn:newsml:reuters.com:*:nL4N2ST2WA
** Visa Inc V.N : up 0.1%
BUZZ-Pay for your coffee using crypto? Visa CFO bets on stablecoins
urn:newsml:reuters.com:*:nL4N2ST2WH
** SentinelOne Inc S.N : down 5.5%
BUZZ-Slides on PT cuts after results, looming lock-up expiration urn:newsml:reuters.com:*:nL4N2ST2W1
** Apple Inc AAPL.O : up 1.9%
BUZZ-Apple about 7% away from becoming the first $3 trln co by market value
urn:newsml:reuters.com:*:nL4N2ST2PA
** Pfizer Inc PFE.N : down 0.5%
BioNTech BNTX.O : down 2.5%
BUZZ-Pare losses as data shows third vaccine dose quells Omicron urn:newsml:reuters.com:*:nL4N2ST2RM
** Weibo Corp WB.O : down 1.4%
BUZZ-U.S.-listed shares of China's Weibo fall after Hong Kong debut
urn:newsml:reuters.com:*:nL4N2ST2US
** Energy Transfer LP ET.N : up 2.2%
BUZZ-Down as CenterPoint's stake sale prices urn:newsml:reuters.com:*:nL1N2ST0NX
** Becton, Dickinson and Co BDX.N : down 1.5%
BUZZ-Piper Sandler cuts to 'neutral' on margin uncertainty urn:newsml:reuters.com:*:nL4N2ST2N4
** Stitch Fix Inc SFIX.O : down 22.1%
BUZZ-Down on Q1 results, Street turns cautious urn:newsml:reuters.com:*:nL4N2ST2MD
** JPMorgan Chase & Co JPM.N : down 1.1%
Goldman Sachs Group Inc GS.N : down 0.6%
Wells Fargo & Co WFC.N : down 1.5%
Bank of America Corp BAC.N : down 0.8%
Citigroup C.N : down 0.2%
Morgan Stanley MS.N : down 0.4%
BUZZ-Major U.S. lenders fall as Treasury yields dip urn:newsml:reuters.com:*:nL4N2ST2MB
** Pfizer Inc PFE.N : down 0.5%
BioNTech BNTX.O : down 2.5%
BUZZ-Fall as study shows vaccine offers partial immunity to Omicron
urn:newsml:reuters.com:*:nL4N2ST2F1
The 11 major S&P 500 sectors:
Communication Services .SPLRCL up 0.55%
Consumer Discretionary .SPLRCD up 0.08%
Consumer Staples .SPLRCS down 0.68%
Energy .SPNY down 0.01%
Financial .SPSY down 0.34%
Health .SPXHC up 0.48%
Industrial .SPLRCI up 0.16%
Information Technology .SPLRCT up 0.08%
Materials .SPLRCM up 0.32%
Real Estate .SPLRCR up 0.49%
Utilities .SPLRCU up 0.12%
(Compiled by Manya Saini in Bengaluru)
((Manya.Saini@thomsonreuters.com))