Final Results

30 June 2023

Igraine Plc

AQSE: KING

(“Igraine” or “the Company”)

Audited Financial Statements for the Year Ended 31 December 2022

The full audited annual report can be found on the Company’s website
https://igraineplc.com.

REVIEW OF BUSINESS

The Directors have been successful in their efforts to minimise the operating
costs of the Company, whilst investments mature.

In July 2022 Sir Professor Christopher Evans, Martin Walton, Burns Singh
Tennent-Bhohi and Richard Walker all stepped down as Directors of the Company.
The Company appreciates all the efforts of the directors who stepped down,
especially Burns Singh Tennent-Bhohi who restructured the company in April
2021 and led the recapitalisation of the company in June 2021.

The Company maintains a truly exceptional working relationship with Sir
Professor Christopher Evans and Martin Walton. Despite their transition from
the board of directors, our partnership remains strong and continues to
flourish. Their extensive experience, valuable guidance, and unwavering
dedication have made an indelible impact on the Company. We are grateful for
their ongoing support.

INVESTEE COMPANY UPDATES

Excalibur Medicines Limited

Excalibur Medicines Limited (“EML”) a subsidiary of Excalibur Healthcare
Services Ltd. EML has secured exclusive rights to and owns the patents on a
drug, AZD1656, which is being developed as a potential therapeutic for
diabetics.

Igraine maintains a 2% equity interest in EML and has the rights to co-invest
in all healthcare and life-science investment opportunities sourced or
invested into by Excalibur Healthcare Services.

In August 2022, EML announced the publication in Lancet eClinicalMedicine of
the Phase 2 clinical trial, ARCADIA, which investigated AZD1656 for people
with diabetes hospitalised with COVID19.

Patients in the AZD1656 arm were observed to have lower mortality;
additionally, AZD1656 was shown to have immunomodulatory capability, as
predicted. The paper also details our sub-group analysis of patients
considered to be at higher risk of worse COVID-19 outcomes, either with
elevated IL-6 or those with low Vitamin D status.

The EML management team have continued to work on their own and through their
network including with the clinical charity, St George Street (SGS) in seeking
commercial opportunities or interest in taking the development of asset
AZD1656 following the phase II clinical trial. EML has also begun to pursue
additional potential opportunities where the asset could be tested in other
non-respiratory indications. The mechanism of action of AZD 1656 was well
observed during the trial and its anti-inflammatory effects and T-Reg
mobilisation to the point of disease suggests that it could be effective in
other areas or organs such as the heart.

As summarised in the paper: “the evidence presented here suggests that
specific activation of T-regs might suppress the inappropriate

inflammation which is the prime cause of tissue damage in autoimmune
disease.”

Oscillate Plc

During the year the Company purchased 21,475,000 shares in Oscillate Plc,
representing approximately 10.2% of Oscillate’s issued share capital.
Oscillate Plc is an investment issuer listed on the AQSE Growth Market
Exchange seeking investment in the medical cannabis sector, special situations
and investments in the medical psychedelic industry. In June 2022, the
Oscillate invested a further £350,000 in Psych Capital and Psych Capital
listed on the AQSE Exchange, at a significantly increased value per share to
the initial total investment, resulting in a profit before tax for the Company
of £572,366. As at year end Oscillate Plc’s cash position was £1,230,961.

Legacy Investment

Following the considerable work associated with the restructure of Igraine,
the Board completed an evaluation of the investment interests acquired prior
to April 2021, including holding meetings with certain board members of the
investees. Upon completing this review, the Board of Directors have deemed
them in majority as non-core to the Company in both present material value and
in contrast the Company’s revised investment strategy.

During the Financial Year, The Company exited its position in Just Bee Honey
Limited (“Just Bee”). Just Bee is a private retail business selling high
quality honey products that have a positive impact on bees. The Company sold
1,840,000 shares (9.14%) in Just Bee Ltd for a total consideration of
£26,680.00.

To the year ending 31 December 2021, the Board of Directors wrote off the
value of the loan receivable by a legacy investee, ASSIF Limited
(“ASSIF”), whilst the Board remain in contact with this investee the Board
were unsatisfied when assessing the realistic recoverability of monies lent to
this investee further compounded by ASSIF making no attempt to repay all sums
owing to date.

POST-YEAR END REVIEW

The Company continues to monitor the development of its maiden investment with
Excalibur under the Co-Investment Agreement. Results to date have been
positive as the Excalibur team progress commercialisation discussions with the
preference being that of a trade sale.

In February 2023, the Company invested £100,000 into Fixit Medical Ltd
(“Fixit”). Fixit, a research and experimental development company focused
on social sciences and humanities, is the sole owner, designer and developer
of Cingo® (“Cingo”), the next drainage catheter fixation device.

Cingo features best in class catheter fixation through a pull-force
dissipating design and an estimated two-week wear time. Cingo also boasts a
revolutionary design that protects catheters from twisting and kinking,
providing easy access to the catheter exit site for improved visibility and
cleaning, and includes a breakthrough integral shower-safe feature. Fixit CEO
and Inventor of Cingo, Dr. Robert Ward, MB BS FRCS FRCR, is a specialist in
vascular and interventional radiology and has developed the most advanced and
patient-centric drainage catheter fixation device available today. Igraine
hold 434 ordinary shares in Fixit representing 20 per cent of Fixit’s share
capital.

Executive Director, Steve Winfield, owns approximately 46% of Larvotto Group
Limited. Larvotto Group Limited itself will have a resulting holding of
approximately 34% of Fixit and acts as an unpaid operational partner and
investor of Fixit Medical Ltd.

ON BEHALF OF THE BOARD:

Mr S Grant-Rennick

Director

DIVIDENDS

The Directors do not propose a dividend in respect of the year ended 31
December 2022 (2021: £nil).

The Directors of the Company accept responsibility for the contents of this
announcement.

 Igraine plc                                                           
 Simon Grant-Rennick                                Tel: 020 7887 1401 
                                                                       
 Peterhouse Capital Ltd ( AQSE Corporate Adviser)   Tel: 020 7469 0930 
 Guy Miller                                         Tel: 020 7220 9795 
 Brefo Gyasi                                                           
                                                                       
                                                                       
                                                                       

   

 Statement of Profit or Loss  for the year ended 31 December 2022                            
                                                                        2022  £       2021 £ 
 CONTINUING OPERATIONS                                                                       
 Other operating income                                                       -       19,824 
 Loss on revaluation of investments                                   (107,375)     (12,798) 
 Administrative expenses                                              (241,315)    (407,615) 
 OPERATING LOSS                                                       (348,690)    (400,589) 

   

 Impairment of loans and trade receivables                    -     (93,405) 
 Interest Income                                          3,329            - 
 LOSS BEFORE INCOME TAX                               (345,361)    (493,994) 
 Income tax                                                   -            - 
 LOSS FOR THE YEAR                                    (345,361)    (493,994) 
 Earnings per share expressed in pence per share:                            
 Basic                                                   -0.004        -0.01 
 Diluted                                                 -0.003       -0.008 

   

 Statement of Profit or Loss and Other Comprehensive Income  for the year ended 31 December 2022 
                                             2022  £     2021 £ 
 LOSS FOR THE YEAR                         (345,361)  (493,994) 
 Other comprehensive income                        -          - 
 TOTAL COMPREHENSIVE INCOME FOR THE YEAR   (345,361)  (493,994) 

   

 Statement of Financial Position  As at 31 December 2022                                
                                                                 2022  £         2021 £ 
 ASSETS                                                                                 
 NON-CURRENT ASSETS                                                                     
 Property, plant and equipment                                         -              - 
 Investments                                                     761,063        615,113 
                                                                 761,063        615,113 
 CURRENT ASSETS                                                                         
 Trade and other receivables                                     134,637        154,067 
 Investments                                                           -          7,205 
 Cash and cash equivalents                                       388,412        904,129 
                                                                 523,049      1,065,401 
 TOTAL ASSETS                                                  1,284,112      1,680,514 
 EQUITY                                                                                 
 SHAREHOLDERS' EQUITY                                                                   
 Called up share capital                                         588,786        588,786 
 Share premium                                                 1,946,995      1,946,995 
 Other reserves                                                   46,116         46,116 
 Retained earnings                                           (1,518,066)    (1,172,705) 
 TOTAL EQUITY                                                  1,063,831      1,409,192 
 LIABILITIES                                                                            
 NON-CURRENT LIABILITIES                                                                
 Financial liabilities - borrowings                                                     
 Interest bearing loans and borrowings                            29,922         38,464 
 CURRENT LIABILITIES                                                                    
 Interest bearing loans and borrowings                             9,768         10,649 
 Trade and other payables                                        180,591        222,209 
 TOTAL LIABILITIES                                               220,281        271,322 
 TOTAL EQUITY AND LIABILITIES                                  1,284,112      1,680,514 

   

 Statement of Changes in Equity  for the year ended 31 December 2022                                                            
                              Called up share capital    Share premium     Other  reserves   Retained earnings     Total equity 
                                                     £                £                  £                    £               £ 
 Balance at 1 January 2021                     554,616           26,818                  -            (678,711)        (97,277) 
 Changes in equity                                                                                                              
 Deficit for the year                                -                -                  -            (493,994)       (493,994) 
 Warrant and Option charge                           -                -             46,116                    -          46,116 
 Total comprehensive income   -                          -                          46,116            (493,994)       (447,878) 
 Transaction cost                                    -        (178,153)                  -                    -       (178,153) 
 Issue of share capital                         34,170        2,098,330                  -                    -       2,132,500 
 Balance at 31 December 2021                   588,786        1,946,995             46,116          (1,172,705)       1,409,192 
 Changes in equity                                                                                                              
 Deficit for the year                                -                -                  -            (345,361)       (345,361) 
 Balance at 31 December 2022                   588,786        1,946,995             46,116          (1,518,066)       1,063,831 

   

 Statement of Cash Flows  for the year ended 31 December 2022       2022  £      2021  £ 
                                                                                         
 Cash flows from operating activities                                                    
 Cash generated from operations                                   (276,575)    (498,688) 
 Net cash from operating activities                               (276,575)    (498,688) 
                                                                                         
 Cash flows from investing activities                                                    
 Purchase of fixed asset investments                              (268,437)    (600,000) 
 Sale of fixed asset investments                                     38,716       13,431 
 Net cash from investing activities                               (229,721)    (586,569) 
                                                                                         
 Cash flows from financing activities                                                    
 Loan repayments in year                                            (9,421)        (887) 
 Share issue (net of share issue costs)                                   -    1,982,462 
 Net cash from financing activities                                 (9,421)  (1,981,575) 
                                                                                         
 (Decrease)/increase in cash and cash equivalents                 (515,717)      896,318 
 Cash and cash equivalents at beginning of year                     904,129        7,811 
 Cash and cash equivalents at end of year                           388,412      904,129 



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