Holding(s) in Company

Igraine plc (AQSE:KING), an investing company focused on breakthrough
innovative technologies and discoveries in the healthcare and life sciences
sectors, has received 2 TR-1 Forms, which are reproduced without amendment
below.

TR-1: Standard form for notification of major holdings

 NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible) (i)                                                                                                                                                                               
                                                                                                                                                                                                                                                                                                          
 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached (ii):                                                          Igraine Plc                                                                                                                    
 1b. Please indicate if the issuer is a non-UK issuer  (please mark with an “X” if appropriate)                                                                                                                                                                                                           
 Non-UK issuer                                                                                                                                                                                                                                                                                            
 2. Reason for the notification (please mark the appropriate box or boxes with an “X”)                                                                                                                                                                                                                    
 An acquisition or disposal of voting rights                                                                                                                                                                                                                            X                                 
 An acquisition or disposal of financial instruments                                                                                                                                                                                                                                                      
 An event changing the breakdown of voting rights                                                                                                                                                                                                                                                         
 Other (please specify) (iii):                                                                                                                                                                                                                                                                            
 3. Details of person subject to the notification obligation (iv)                                                                                                                                                                                                                                         
 Name                                                                                                                                                                      Oscillate plc                                                                                                                  
 City and country of registered office (if applicable)                                                                                                                     London, UK                                                                                                                     
 4. Full name of shareholder(s) (if different from 3.) (v)                                                                                                                                                                                                                                                
 Name                                                                                                                                                                                                                                                                                                     
 City and country of registered office (if applicable)                                                                                                                                                                                                                                                    
 5. Date on which the threshold was crossed or reached (vi):                                                                                                               14 July 2023                                                                                                                   
 6. Date on which issuer notified (DD/MM/YYYY):                                                                                                                            19 July 2023                                                                                                                   
 7. Total positions of person(s) subject to the notification obligation                                                                                                                                                                                                                                   
                                                                            % of voting rights attached to shares (total of 8. A)  % of voting rights through financial instruments                   Total of both in % (8.A + 8.B)  Total number of voting rights held in issuer (8.A + 8.B) (vii)      
                                                                                                                                   (total of 8.B 1 + 8.B 2)                                                                                                                                               
 Resulting situation on the date on which threshold was crossed or reached  0%                                                                                                                                                        0                                                                   
 Position of previous notification (if applicable)                          24.64%                                                                                                                                                    21,312,460                                                          
                                                                                                                                                                                                                                                                                                          

 8. Notified details of the resulting situation on the date on which the threshold was crossed or reached (viii)                                                                                                        
 A: Voting rights attached to shares                                                                                                                                                                                    
 Class/type of                                   Number of voting rights (ix)                                                         % of voting rights                                                                
 sharesISIN code (if possible)                                                                                                                                                                                          
                                                 Direct(DTR5.1)            Indirect (DTR5.2.1)                                        Direct(DTR5.1)                                                Indirect(DTR5.2.1)  
 GB00BM9CKV18                                    21,312,460                                                                           24.64%                                                                            
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
 SUBTOTAL 8. A                                   21,312,460                                                                           24.64%                                                                            
                                                                                                                                                                                                                        
 B 1: Financial Instruments according to DTR5.3.1R (1) (a)                                                                                                                                                              
 Type of financial instrument                    Expiration  Exercise/                                 Number of voting rights that may be acquired if the instrument is exercised/converted.       % of voting rights  
                                                 date (x)    Conversion Period (xi)                                                                                                                                     
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                             SUBTOTAL 8. B 1                                                                                                                                            
                                                                                                                                                                                                                        
 B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)                                                                                                                                 
 Type of financial instrument  Expiration                    Exercise/                   Physical or cash Settlement (xii)                                           Number of voting rights        % of voting rights  
                               date (x)                      Conversion Period (xi)                                                                                                                                     
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                         SUBTOTAL 8.B.2                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        

 9. Information in relation to the person subject to the notification obligation (please mark the applicable box with an “X”)                                                                                                                                                                                                                     
 Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer (xiii)                                                                                                                 
 Full chain of controlled undertakings through which the voting rights and/or the                                                                                                                                                                                                                                                                 
 financial instruments are effectively held starting with the ultimate controlling natural person or legal entity (please add additional rows as necessary) (xiv)                                                                                                                                                                                 
 Name (xv)                                                  % of voting rights if it equals or is higher than the notifiable threshold  % of voting rights through financial instruments if it equals or is higher than the notifiable threshold  Total of both if it equals or is higher than the notifiable threshold                           
 Oscillate plc                                              0%                                                                                                                                                                                    0%                                                                                              
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
 10. In case of proxy voting, please identify:                                                                                                                                                                                                                                                                                                    
 Name of the proxy holder                                                                                                                                                                                                                                                                                                                         
 The number and % of voting rights held                                                                                                                                                                                                                                                                                                           
 The date until which the voting rights will be held                                                                                                                                                                                                                                                                                              
                                                                                                                                                                                                                                                                                                                                                  
 11. Additional information (xvi)                                                                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  

 Place of completion  London, UK    
 Date of completion   14 July 2023  

 Please note that from 22 March 2021, the Standard TR-1 Form should be completed and submitted to the FCA via our Electronic Submission System (ESS) in relation to notifications of voting rights held in issuers whose shares are admitted to trading on UK regulated markets.Holders of voting rights in issuers whose shares are admitted to trading on UK prescribed markets such as AIM market, can continue to use this form to send their notifications to those issuers. Alternatively, if they wish they can register  
 on ESS to be able to notify to us, produce a TR-1 Form via ESS and submit the downloaded version to issuers with shares admitted to trading on  prescribed markets.More information on how to submit a TR-1 Form via ESS is available here (https://www.fca.org.uk/markets/primary-markets/regulatory-disclosures/shareholding-notification-disclosure)                                                                                                                                                                         

TR-1: Standard form for notification of major holdings

 NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible) (i)                                                                                                                                                                               
                                                                                                                                                                                                                                                                                                          
 1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached (ii):                                                          Igraine Plc                                                                                                                    
 1b. Please indicate if the issuer is a non-UK issuer  (please mark with an “X” if appropriate)                                                                                                                                                                                                           
 Non-UK issuer                                                                                                                                                                                                                                                                                            
 2. Reason for the notification (please mark the appropriate box or boxes with an “X”)                                                                                                                                                                                                                    
 An acquisition or disposal of voting rights                                                                                                                                                                                                                            X                                 
 An acquisition or disposal of financial instruments                                                                                                                                                                                                                                                      
 An event changing the breakdown of voting rights                                                                                                                                                                                                                                                         
 Other (please specify) (iii):                                                                                                                                                                                                                                                                            
 3. Details of person subject to the notification obligation (iv)                                                                                                                                                                                                                                         
 Name                                                                                                                                                                      Paul Johnson                                                                                                                   
 City and country of registered office (if applicable)                                                                                                                     London, UK                                                                                                                     
 4. Full name of shareholder(s) (if different from 3.) (v)                                                                                                                                                                                                                                                
 Name                                                                                                                                                                                                                                                                                                     
 City and country of registered office (if applicable)                                                                                                                                                                                                                                                    
 5. Date on which the threshold was crossed or reached (vi):                                                                                                               14 July 2023                                                                                                                   
 6. Date on which issuer notified (DD/MM/YYYY):                                                                                                                            19 July 2023                                                                                                                   
 7. Total positions of person(s) subject to the notification obligation                                                                                                                                                                                                                                   
                                                                            % of voting rights attached to shares (total of 8. A)  % of voting rights through financial instruments                   Total of both in % (8.A + 8.B)  Total number of voting rights held in issuer (8.A + 8.B) (vii)      
                                                                                                                                   (total of 8.B 1 + 8.B 2)                                                                                                                                               
 Resulting situation on the date on which threshold was crossed or reached  24.64%                                                                                                                                                    21,312,460                                                          
 Position of previous notification (if applicable)                          0%                                                                                                                                                        0                                                                   
                                                                                                                                                                                                                                                                                                          

 8. Notified details of the resulting situation on the date on which the threshold was crossed or reached (viii)                                                                                                        
 A: Voting rights attached to shares                                                                                                                                                                                    
 Class/type of                                   Number of voting rights (ix)                                                         % of voting rights                                                                
 sharesISIN code (if possible)                                                                                                                                                                                          
                                                 Direct(DTR5.1)            Indirect (DTR5.2.1)                                        Direct(DTR5.1)                                                Indirect(DTR5.2.1)  
 GB00BM9CKV18                                    21,312,460                                                                           24.64%                                                                            
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
 SUBTOTAL 8. A                                   21,312,460                                                                           24.64%                                                                            
                                                                                                                                                                                                                        
 B 1: Financial Instruments according to DTR5.3.1R (1) (a)                                                                                                                                                              
 Type of financial instrument                    Expiration  Exercise/                                 Number of voting rights that may be acquired if the instrument is exercised/converted.       % of voting rights  
                                                 date (x)    Conversion Period (xi)                                                                                                                                     
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                             SUBTOTAL 8. B 1                                                                                                                                            
                                                                                                                                                                                                                        
 B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)                                                                                                                                 
 Type of financial instrument  Expiration                    Exercise/                   Physical or cash Settlement (xii)                                           Number of voting rights        % of voting rights  
                               date (x)                      Conversion Period (xi)                                                                                                                                     
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        
                                                                                         SUBTOTAL 8.B.2                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                                                                                                                                        

 9. Information in relation to the person subject to the notification obligation (please mark the applicable box with an “X”)                                                                                                                                                                                                                     
 Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer (xiii)                                                                                                                 
 Full chain of controlled undertakings through which the voting rights and/or the                                                                                                                                                                                                                                                                 
 financial instruments are effectively held starting with the ultimate controlling natural person or legal entity (please add additional rows as necessary) (xiv)                                                                                                                                                                                 
 Name (xv)                                                  % of voting rights if it equals or is higher than the notifiable threshold  % of voting rights through financial instruments if it equals or is higher than the notifiable threshold  Total of both if it equals or is higher than the notifiable threshold                           
 Oscillate plc                                              0%                                                                                                                                                                                    0%                                                                                              
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  
 10. In case of proxy voting, please identify:                                                                                                                                                                                                                                                                                                    
 Name of the proxy holder                                                                                                                                                                                                                                                                                                                         
 The number and % of voting rights held                                                                                                                                                                                                                                                                                                           
 The date until which the voting rights will be held                                                                                                                                                                                                                                                                                              
                                                                                                                                                                                                                                                                                                                                                  
 11. Additional information (xvi)                                                                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                                                                                                                                                  
                                                                                                                                                                                                                                                                                                                                                  

 Place of completion  London, UK    
 Date of completion   14 July 2023  



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