** Galera Therapeutics Inc's shares GRTX.O down 69% at
$2.27 - top pct loser on Nasdaq Composite index .IXIC and set
for worst day on record
** GRTX hit a record low of $1.96 earlier in the session
** GRTX says its lead drug Avasopasem failed to meet primary
endpoint of reduction in radiotherapy-induced severe oral
mucositis in late-stage trial urn:newsml:reuters.com:*:nFWN2RF04S
** More than 26 million shares traded, the highest on record
for GRTX since it went public in November 2019
** Brokerage BTIG says lack of significance at the primary
endpoint creates a high barrier for acceptance by regulatory
authorities, despite material unmet need in the population;
downgrading GRTX to 'neutral' from 'buy', and removes PT
** Including session's losses, stock had slumped 78% YTD
compared with a 17% increase in the Nasdaq Composite index
(Reporting by Leroy Leo in Bengaluru)
((Leroy.Dsouza@thomsonreuters.com;))