REG - Genflow Biosciences - Second European Patent Application

Genflow BiosciencesAnnouncement

22/10/2025 07:00

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RNS Number : 2934E  Genflow Biosciences PLC  22 October 2025

 

 

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22 October 2025

 

Genflow Biosciences Plc

 

Publication of Second European Patent Application - SIRT6 Variant for NASH

 

Genflow Biosciences Plc (LSE:GENF) (OTCQB:GENFF) ("Genflow" or the "Company"),
the only publicly listed longevity company in Europe, is pleased to announce
that its second European patent application (Application No. 23821586.7,
Publication No. EP4630038) titled "SIRT6 Variant for NASH" has been published
in the European Patent Bulletin ("EPO").

 

Publication of the patent application in the European Patent Bulletin follows
entry into the European phase under the Patent Cooperation Treaty (PCT) and
represents a key milestone in

Genflow's expanding intellectual property (IP) portfolio.

This publication confers provisional protection under Article 67(3) of the
European Patent Convention (EPC), enabling Genflow to claim retroactive
damages in designated EPC states for infringing acts occurring after the
publication date, once the patent is formally granted and national validation
requirements are met.

 

Strategic Significance

This development marks continued progress in Genflow's comprehensive patent
strategy to strengthen protection for its SIRT6 gene variant technologies and
expand their therapeutic reach across metabolic and age-related disorders,
including NASH (non-alcoholic steatohepatitis). It also reinforces Genflow's
IP leadership in the longevity and metabolic disease space, complementing the
recently published EP4338267 covering the Company's core SIRT6 variant for
healthy aging. Together, these filings establish a robust European patent
framework supporting Genflow's therapeutic platform and upcoming clinical
programs.

 

Dr. Eric Leire, Chief Executive Officer of Genflow Biosciences, commented:
"The publication of our second European patent marks another important
validation of our science and IP strategy. With both of our key SIRT6
applications now public and provisionally enforceable in Europe, we have
solidified the foundation for long-term value creation, enhanced partnership
potential, and future grant protection across our portfolio."

 

Contacts

 Genflow Biosciences  Harbor Access
 Dr Eric Leire, CEO   Jonathan Paterson, Investor Relations
 +32-477-495-881      +1 475 477 9401
                      Jonathan.Paterson@Harbor-access.com

 

About Genflow Biosciences

 

Founded in 2020, Genflow Biosciences Plc. (LSE:GENF) (OTCQB:GENFF), a
biotechnology company headquartered in the UK with R&D facilities in
Belgium, is pioneering gene therapies to decelerate the aging process, with
the goal of promoting longer and healthier lives while mitigating the
financial, emotional, and social impacts of a fast-growing aging global
population. Genflow's lead compound, GF-1002, works through the delivery of a
centenarian variant of the SIRT6 gene which has yielded promising results.
Genflow's 12-month proof-of-concept clinical trial evaluating their
SIRT6-centenarian gene therapy in aged dogs began in March 2025. Other
programs planned include a clinical trial that will explore the potential
benefits of GF-1002 in treating MASH (Metabolic Dysfunction-Associated
Steatohepatitis), the most prevalent chronic liver disease for which there are
no effective treatments. Please visit www.genflowbio.com
(http://www.genflowbio.com/)   and follow the Company on LinkedIn
(https://www.linkedin.com/company/genflow-biosciences/?viewAsMember=true)
 and X (https://x.com/genflowbio) .

 

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