** Shares of cancer test maker Grail GRAL.O fall 52% to $49 premarket
** Co says its test for early cancer detection failed in large study
** Says main result of trial was not statistically significant but favorable trend was observed over time
** GRAL says it already sells the test called Galleri and has applied for FDA approval
** The Galleri trial is run with England's National Health Service and uses blood test aiming to detect cancers early by spotting DNA shed by tumors into bloodstream, GRAL says
** Stock up ~68% in 2025
(Reporting by Sahil Pandey in Bengaluru)
((Sahil.Pandey@thomsonreuters.com))