REG - Hemogenyx Pharma Plc - Site Initiation Visit Completed

Hemogenyx PharmaceuticalsAnnouncement

09/12/2024 07:00

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RNS Number : 2714P  Hemogenyx Pharmaceuticals PLC  09 December 2024

9 December 2024

 

Hemogenyx Pharmaceuticals plc

("Hemogenyx Pharmaceuticals" or the "Company")

 

Site Initiation Visit Completed

 

Hemogenyx Pharmaceuticals Successfully Completes the Site Initiation Visit of
the First Clinical Site for Phase I Clinical Trial of HG-CT-1

 

Hemogenyx Pharmaceuticals plc (LSE: HEMO), the biopharmaceutical company
developing innovative therapies for blood diseases, is pleased to announce the
successful completion of the Site Initiation Visit at the first clinical site
for its Phase I clinical trial of HG-CT-1 (also known as HEMO-CAR-T). The
Phase I clinical trial is designed as a dose escalation study to assess the
safety of HG-CT-1 in adult patients with relapsed/refractory (R/R) acute
myeloid leukaemia (AML).

Patient recruitment will begin once the clinical site provides final details
to the Company's  clinical trials manager, Prevail Infoworks.

 

 

Dr Vladislav Sandler, CEO & Co-Founder of Hemogenyx Pharmaceuticals,
commented:
"This step marks a significant milestone for the Company as we advance our
lead asset, HG-CT-1, into clinical trials. This study represents our
commitment to developing innovative therapies for patients with R/R AML, a
condition with limited treatment options.

We are excited to see patient recruitment set to begin and take the next steps
in assessing the safety and treatment potential of HEMO-CAR-T. We remain
dedicated to delivering transformative therapies that address critical unmet
medical needs."

 

About AML and CAR-T Therapy

AML, the most common type of acute leukemia in adults, has poor survival rates
(a five-year survival rate of less than 30% in adults) and is currently
treated using chemotherapy, rather than the potentially more benign and
effective forms of therapy being developed by Hemogenyx Pharmaceuticals. The
successful development of a new therapy for AML would have a major impact on
treatment and survival rates for the disease.

CAR-T therapy is a treatment in which a patient's own T-cells, a type of
immune cell, are modified to recognize and kill the patient's cancer cells.
The procedure involves: isolating T-cells from the patient; modifying the
isolated T-cells in a laboratory using a CAR gene construct (which allows the
cells to recognize the patient's cancer); amplifying (growing to large
numbers) the newly modified cells; and re-introducing the cells back into the
patient.

 

Market Abuse Regulation (MAR) Disclosure

Certain information contained in this announcement would have been inside
information for the purposes of Article 7 of Regulation No 596/2014 (as it
forms part of UK domestic law by virtue of the European Union (Withdrawal) Act
2018) until the release of this announcement. The person responsible for
arranging for the release of this announcement on behalf of Hemogenyx
Pharmaceuticals plc is Dr Vladislav Sandler, Chief Executive Officer &
Co-Founder.

 

 

 

Enquiries:

 

 Hemogenyx Pharmaceuticals plc                                   https://hemogenyx.com (https://hemogenyx.com/)
 Dr Vladislav Sandler, Chief Executive Officer & Co-Founder      headquarters@hemogenyx.com (mailto:headquarters@hemogenyx.com)
 Peter Redmond, Director                                         peter.redmond@hemogenyx.com (mailto:peter.redmond@hemogenyx.com)

 SP Angel Corporate Finance LLP                                  Tel: +44 (0)20 3470 0470
 Matthew Johnson, Vadim Alexandre, Adam Cowl

 Peterhouse Capital Limited                                      Tel: +44 (0)20 7469 0930
 Lucy Williams, Duncan Vasey, Charles Goodfellow

 

 

About Hemogenyx Pharmaceuticals plc

Hemogenyx Pharmaceuticals is a publicly traded company (LSE: HEMO)
headquartered in London, with its US operating subsidiaries, Hemogenyx
Pharmaceuticals LLC and Immugenyx LLC, located in New York City at its
state-of-the-art research facility.

The Company is a clinical stage biopharmaceutical group developing new
medicines and treatments to treat blood and autoimmune disease and to bring
the curative power of bone marrow transplantation to a greater number of
patients suffering from otherwise incurable life-threatening diseases.
Hemogenyx Pharmaceuticals is developing several distinct and complementary
product candidates, as well as a platform technology that it uses as an engine
for novel product development.

 

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