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- The major U.S. stock indexes edged lower on Tuesday as fresh hostilities in the Middle East pushed oil prices to their highest since late July, while markets await inflation data due later this week. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was down 1.00% at 52,882.78. The S&P 500 .SPX was down 0.32% at 7,694.26, and the Nasdaq Composite .IXIC was down 0.08% at 26,486.53.

The top three S&P 500 .PG.INX percentage gainers:

** Lumentum Holdings Inc. LITE.OQ, up 11.9%

** Coherent Corp. COHR.N, up 10.6%

** Corning Incorporated GLW.N, up 9.2%

The top three S&P 500 .PL.INX percentage losers:

** Amgen Inc AMGN.OQ, down 9.6%

** Stryker Corporation SYK.N, down 8.5%

** GoDaddy Inc. GDDY.N, down 7.0%

The top three NYSE .PG.N percentage gainers:

** GrafTech International Ltd EAF.N, up 16.9%

** Solaris Energy Infrastructure, Inc. SEI.N, up 16.6%

** Nuscale Power Corp SMR.N, up 14.1%

The top three NYSE .PL.N percentage losers:

** Novartis AG NVS.N, down 13.5%

** N-Able Inc NABL.N, down 10.0%

** CI&T Inc. CINT.N, down 9.2%

The top three Nasdaq .PG.O percentage gainers:

** NuRAN Wireless Inc NUR.OQ, up 129.7%

** CEA Industries Inc BNC.OQ, up 47.9%

** Indaptus Therapeutics Inc INDP.OQ, up 36.9%

The top three Nasdaq .PL.O percentage losers:

** Focus Universal Inc FCUV.OQ, down 64.2%

** bioAffinity Technologies Inc BIAF.OQ, down 41.1%

** Lexaria Bioscience Corp LEXX.OQ, down 33.6%

** Sigma Lithium Corp SGML.N:
BUZZ - Falls after Brazil court suspends mining at Grota do Cirilo mine nL6N4500FJ

** Shake Shack Inc SHAK.N:
BUZZ - Rises after RBC initiates coverage with 'outperform' nL6N4500G1

** Novartis AG NVS.N:
BUZZ - Hits record high on retina drugs distribution deal, Pfizer brand acquisition nL4N4500KV

** Amgen Inc AMGN.O:
BUZZ - Falls after Novartis trial setback, BMO downgrade nL4N4500KO

** Everpure Inc P.N:

** Illumina Inc ILMN.O:
BUZZ - Gain on S&P 500 inclusion nL4N4500KP

** Biohaven Ltd BHVN.N:
BUZZ - RBC downgrades Biohaven to 'sector perform', shares fall nL4N4500MG

** Roivant Sciences Ltd ROIV.O:
BUZZ - Jumps after lung disease drug meets main goal in mid-stage study nL4N45013K

** Autoliv Inc ALV.N:
BUZZ - Falls after TD Cowen downgrades to 'hold', cuts PT nL4N4500QI

** Sarepta Therapeutics Inc SRPT.O:

** Dyne Therapeutics Inc DYN.O:
BUZZ - Fall after Novartis muscle disorder trial failure nL4N450158

** Boston Scientific Corp BSX.N:
BUZZ - Falls as cyberattack seen hurting 2026 sales, profit nL6N4500JU

** C.H. Robinson Worldwide Inc CHRW.O:
BUZZ - Citigroup upgrades C.H. Robinson to 'buy' as freight market conditions improve nL4N4500RS

** Ionis Pharmaceuticals Inc IONS.O:
BUZZ - Tumbles after heart drug fails late-stage trial nL4N4500PU

** Rigetti Computing Inc RGTI.O:
BUZZ - Climbs on $100 million US government deal nL6N4500LO

** United Natural Foods Inc UNFI.N:
BUZZ - Jumps on Q4 earnings beat, upbeat annual outlook nL4N4500VU

** Pharvaris NV PHVS.O:
BUZZ - Gains after genetic disorder drug meets late-stage trial goal nL4N4500UD

** IonQ Inc IONQ.N:
BUZZ - Rises as it raises full-year revenue outlook nL4N4500UF

** Solaris Energy Infrastructure Inc SEI.N:
BUZZ - Up after raising quarterly forecasts nL6N4500M5

** Bloom Energy Corp BE.N:
BUZZ - Jumps ahead of S&P 500 addition nL6N4500MF

** Intellia Therapeutics Inc NTLA.O:
BUZZ - Rises after FDA grants fast-track status to its treatment for rare disease nL4N4500YD

** ABM Industries Inc ABM.N:
BUZZ - Falls after Q3 revenue misses estimates nL6N4500NV

** Qualcomm Inc QCOM.O:
BUZZ - Rises after deal with Amazon to develop custom chips for AI data centers nL6N4500PM

** Definium Therapeutics Inc DFTX.O:
BUZZ - Rises on FDA's 'breakthrough' tag for depression drug nL4N45013M

** Eaton Corporation PLC ETN.N:
BUZZ - Climbs as UBS turns bullish on data center strength nL6N4500R7

** Howmet Aerospace Inc HWM.N:
BUZZ - Falls after GE Aerospace agrees to buy CPP for $11.75 billion nL4N450178

Index RIC

Index name

Percent change %

.SPX

S&P 500

-0.32

.SPLRCT

S&P 500 Information Technology

0.18

.SPLRCU

S&P 500 Utilities

0.99

.SPLRCD

S&P 500 Consumer Discretionary

-0.26

.SPLRCM

S&P 500 Materials

-0.1

.SPLRCI

S&P 500 Industrials

-0.04

.SPLRCL

S&P 500 Communication Services (Sector)

-0.26

.SPSY

S&P 500 Financials

-0.97

.SPLRCR

S&P 500 Real Estate

0.35

.SPXHC

S&P 500 Health Care

-2.63

.SPLRCS

S&P 500 Consumer Staples

-0.77

.SPNY

S&P 500 Energy

1.1


(Compiled by Rajarshi Roy and Megavarshini G. Somasundaram in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))

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