** Two major clinical data readouts in 2023 for Icosavax
Inc's ICVX.O RSV vaccine candidates present a greater upside
than downside for the vaccine maker, says Jefferies
** ICVX is on track to report 12-month durability data in
mid-2023 for IVX-121, its respiratory syncytial virus (RSV)
vaccine candidate - brokerage
** Data readout can help differentiate Icosavax's candidate
from other RSV vaccine programs, including from larger rivals
such as Pfizer Inc PFE.N and Moderna Inc MRNA.O , due to its
higher durable immune response seen in the six-month data, says
Jefferies
** ICVX is also set to share data from early-stage
combination vaccine IVX-A12 in mid-2023, which targets both RSV
and another respiratory disease called human metapneumovirus
** The combo vaccine can be a distinguished candidate for
older adults and help ICVX target a niche market of $5 bln-$10
bln - brokerage
** While the focus remains on ICVX's RSV franchise, its
other pipeline programs, including bivalent COVID-19 vaccine
candidate selection planned this year, show promise
** RSV is a respiratory disease that causes symptoms similar
to a cold but can be fatal for young children and older adults
** All 5 brokerages covering the stock rate "buy" or higher;
median PT is $27, representing an over 3x premium to stock's
last close - Refinitiv
** ICVX has fallen 40.2% in the past 12 months
(Reporting by Bhanvi Satija in Bengaluru)
((Bhanvi.Satija@thomsonreuters.com; Outside U.S. +91
9873062788))