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REG - Immupharma PLC - Interim results

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RNS Number : 8715K  Immupharma PLC  31 August 2023

RNS: RELEASE | 31 August 2023

 

 

ImmuPharma PLC

("ImmuPharma" or the "Company")

 

INTERIM RESULTS

for the six months ended 30 June 2023

 

ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug
discovery and development company, is pleased to announce its interim results
for the six months ended 30 June 2023 (the "Period").

 

Key Highlights (including post Period review)

 

Financials

·   Loss for the Period of £0.8m (30 June 2022:  £1.7m)

·   Research and development expenses of £0.8m (30 June 2022: £1.0m)

·   Administrative expenses of £0.4m (30 June 2022: £0.6m)

·   Share based expense of £0.1m (30 June 2022: £0.1m)

·   Cash balance of £0.2m as at 30 June 2023 (31 December 2022:
 £0.2m)

·   Derivative financial asset of £0.6m as at 30 June 2023 (31 December
2022: £0.6m)

·   Basic and diluted loss per share of 0.25p (30 June 2022: 0.58p)

·   Successful fundraising - see separate announcement today

 

Portfolio

·    In February 2023 an adaptive Phase 2/3 study for Lupuzor™ in
SLE/Lupus patients was agreed with US partner, Avion Pharmaceuticals.

·    In March 2023 a collaboration with Orano SA on ImmuPharma's peptide
technology was announced.

·    In May 2023, ImmuPharma received positive guidance from the Food and
Drug Administration ("FDA") following the Pre-Investigational New Drug
("PIND") meeting supporting a Phase 2/3 adaptive clinical study of P140 in
CIDP.

 

·    In June 2023, confirmation that following receipt of comprehensive
guidance from the FDA, a Phase 2/3 adaptive clinical trial of P140
(Lupuzor™) in patients with Lupus will commence in H2 2023.

 

·    Established discussions with new potential corporate partners across
the P140 platform and anti-infective programmes.

 

 

 

Corporate

·    In August 2023, the Board was strengthened with two NED appointments:
Dr Laurence Reilly & Dr Sébastien Goudreau.

 

Commenting on the statement and outlook Tim McCarthy, CEO and Chairman, said:

 

"We continue to make positive progressive steps for ImmuPharma. As a Board, we
remain focused on bringing our two key late stage P140 clinical assets in
Lupus and CIDP through their final clinical trials and to the market.

The drive to conclude further commercial and partnering deals will be
accelerated over this next period and which is now bolstered by the recently
announced new Board appointments.

The Board would like to take this opportunity to thank its shareholders for
their continued patience and support, as well as its staff, corporate and
scientific advisers and our partners including CNRS and Avion."

 

Market Abuse Regulation (MAR) Disclosure

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION AS STIPULATED UNDER THE UK
VERSION OF THE MARKET ABUSE REGULATION NO 596/2014 WHICH IS PART OF UK LAW BY
VIRTUE OF THE EUROPEAN UNION (WITHDRAWAL) ACT 2018, AS AMENDED.  ON
PUBLICATION OF THIS ANNOUNCEMENT VIA A REGULATORY INFORMATION SERVICE, THIS
INFORMATION IS CONSIDERED TO BE IN THE PUBLIC DOMAIN.

 For further information please contact:

ImmuPharma PLC (www.immupharma.co.uk)               + 44 (0) 2072 062650
 Tim McCarthy, Chief Executive Officer and Chairman

 Lisa Baderoon, Head of Investor Relations           + 44 (0) 7721 413496

 SPARK Advisory Partners Limited (NOMAD)             +44 (0) 203 368 8974 (tel:0113%20370%208974)

 Neil Baldwin

 Stanford Capital Partners (Joint Broker)            +44 (0) 203 815 8880

 Patrick Claridge, Bob Pountney

 SI Capital (Joint Broker)                           +44 (0) 1483 413500

 Nick Emerson

 

A copy of the interim report is available on the Company's website
www.immupharma.co.uk

 

 

 

 

ImmuPharma plc

 

INTERIM RESULTS

 

FOR THE SIX MONTH PERIOD ENDED 30 JUNE 2023

 

 

 

 

 

ImmuPharma plc

 

Chairman's Statement

 

The first part of 2023 was a period of further progress for ImmuPharma, as we
continued to focus on progressing our late-stage pipeline assets specifically,
within our P140 autoimmune platform.

 

Most recently in June, the Company announced that, after receiving
comprehensive guidance from the Food and Drug Administration ("FDA") on the
new Phase 2/3 adaptive clinical trial protocol for the lead programme for the
treatment of patients with systemic lupus erythematosus ("SLE/Lupus"), it is
moving forward with the study, together with its US partner Avion
Pharmaceuticals ("Avion").

Positive progress was also announced in May for a second high medical need
disease, chronic idiopathic demyelinating polyneuropathy ("CIDP"). The Company
received positive feedback from the FDA at a pre-IND meeting for a late-stage
Phase 2/3 adaptive clinical program in patients, which is a further
debilitating auto-immune condition within the Company's P140 platform.

In parallel with advancements in the late-stage clinical developments, the
Company is also actively in discussions with a number of potential commercial
partners for programmes across the Company's development portfolio.

 

Lupuzor™/P140 - opportunity and next steps

 

There are an estimated five million people suffering from Lupus, with
approximately 5 million patients in the US, Europe and Japan (Source: Lupus
Foundation of America). The prevalence in China may be 2-3 times that seen in
the US. Current 'standard of care' treatments, including steroids and
immunosuppressants, can potentially have either serious side effects for
patients or limited efficacy, with over 60 per cent of patients not adequately
treated.

 

ImmuPharma believes Lupuzor™/P140 has the potential to be a novel specific
drug therapy for the treatment of Lupus by specifically modulating the immune
system and halting disease progression in most Lupus patients. It has a unique
mechanism of action and is not an immunosuppressant like other drugs.
Lupuzor™/P140 normalises the over-activity of T-cells which are involved in
the immune response leading to Lupus disease. Lupuzor™ taken over the long
term may have the potential to prevent the progression of Lupus rather than
just treating its symptoms, with the rest of the immune system retaining the
ability to work normally.

 

A new major opportunity for P140 is CIDP, a rare acquired autoimmune disorder
of peripheral nerves. It is a neurological disorder characterized by
progressive weakness and impaired sensory function in the legs and arms. CIDP
is a potential orphan drug indication which would provide patent life
extension of 7 years post-approval.

 

The Board is confident that there is a route to market for P140 in Lupus and
CIDP including further corporate collaborations.

 

Lupuzor™ Phase 2/3 Adaptive Study

 

As announced in June 2023, following the receipt of comprehensive guidance
from the FDA, in conjunction with our US partner Avion, a Phase 2/3 adaptive
clinical trial of P140 (Lupuzor™) in patients with Lupus will commence in H2
2023.

 

 

The trial design and protocol is substantially different from previous
clinical trials that ImmuPharma has completed and includes maintaining
subcutaneous dosing but at much higher concentrations and significant changes
to patient inclusion criteria and primary and secondary clinical endpoints.

The detailed protocol and key elements of the clinical trial design will be
communicated at a later stage once the details of the trial are available on
clinicaltrials.gov (a comprehensive database of privately and publicly funded
clinical studies conducted around the world).

 

Lupus ABC Consortium

 

The FDA's Center for Drug Evaluation and Research ("CDER") has partnered with
the Lupus Research Alliance ("LRA") to launch the Lupus Accelerating
Breakthroughs Consortium ("Lupus ABC"), a first-of-its-kind public-private
partnership focused on addressing challenges impacting Lupus clinical trial
success.

 

Lupus ABC will convene people living with Lupus, medical societies, industry,
academic clinical researchers and scientists, FDA, and other federal agencies
to address scientific hurdles that are beyond the capacity of any single
entity. By connecting those with lived experience with all parties involved in
Lupus treatment research, CDER hopes to advance the development of urgently
needed treatments for Lupus.

 

This can only be extremely good news for Lupus patients worldwide, including
ImmuPharma, our partners and our peers, in bringing new safe Lupus drugs to
the market, sooner rather than later.

 

CIDP / P140

 

For P140 in CIDP we announced in April 2023 that we had received confirmation
from the FDA for a pre- Investigational New Drug ("PIND") meeting date of 16
May 2023, to consider a Phase 2/3 adaptive trial study protocol.

 

In May 2023, ImmuPharma received positive guidance from FDA following the PIND
meeting that confirms the route for a Phase 2/3 adaptive clinical study of
P140 in CIDP.

 

The FDA feedback recognises that P140 is suitable to be studied in another
disease indication in addition to SLE and this strongly supports the
underlying science and mechanism of action of P140 across several
auto-immune/inflammatory diseases and is a significant breakthrough for the
P140 platform.

 

The Phase 2/3 adaptive clinical trial will be the first pivotal stage study of
P140 in patients with CIDP: a rare neurological disease with high medical
need.

 

An IND application is now being prepared for submission to the FDA,
incorporating all guidance points. An application for Orphan Drug status for
CIDP will be also submitted in parallel to the full IND application.

 

The CIDP market is expected to reach global sales of US$2.7bn by 2029.

 

 

 

 

 

 

 

Anti-Infection

 

The innovative peptide technology at ImmuPharma Biotech has been a huge
success and very recently has given rise to a number of novel development
programs, out of which we have identified two core programs: BioAMB and
BioCin, which we believe have the best commercial opportunity and speed to
market. These programs are based on existing drugs that have been used for
decades so the PK, efficacy and safety of those drugs is well understood. They
will also be patent protected.

 

o  BioAMB, a novel peptide-based drug that offers a potential improvement on
the limiting side effects and poor administration regime of current
Amphotericin-B ("AMB") formulations. AMB is one of a last line of agents
against serious and life-threatening fungal infections caused by the
aspergillus family of fungi.

 

o  BioCin, a novel peptide-based drug based on an existing potent
antibacterial, vancomycin, used in high medical need cases and in many cases
the last line of defense. BioCin has the potential to offer improved safety
and administration benefits.

 

Pipeline Overview

 

Our therapeutic focus is on two core areas; Autoimmunity/Inflammation and
Anti-infection. We also look for valuable deals for non-core assets as
evidenced by a collaborative deal, signed in March 2023, with Orano SA on
ImmuPharma's peptide technology as a vector for cancer radiotherapy. The
initial collaboration is for 12 months, and a small undisclosed upfront
payment was paid to ImmuPharma.

 

Commercial Activities

 

Management has established discussions with new potential corporate partners
across the P140 platform and anti-infective programmes. The drive to conclude
further commercial and partnering deals will be accelerated over this next
period and which is now bolstered by the recently announced new Board
appointments.

 

Centre National de la Recherche Scientifique (CNRS)

 

ImmuPharma continues to have important collaboration arrangements with the
Centre National de la Recherche Scientifique ("CNRS"), the French National
Council for Scientific Research and the largest basic research organisation in
Europe. This is where Lupuzor™ /P140 platform was invented by Prof. Sylviane
Muller, Emeritus Research Director at the CNRS.

 

Interest in Incanthera Plc

 

As at 30 June 2023, ImmuPharma had a 12.7% interest in oncology specialist,
Incanthera plc, which trades on Aquis Stock Exchange ("AQSE") under the ticker
(TIDM:INC).

 

ImmuPharma also has 7,272,740 warrants in Incanthera at an exercise price of
9.5p. As most recently announced in August 2023, the term of these Warrants
has been extended by 12 months to 6 September 2024.

 

As announced in Incanthera's interim report in December 2022, the Company
continues to concentrate upon furthering discussions to capitalise on the
potential for various applications of its skincare portfolio for commercial
success.

 

As a major shareholder, ImmuPharma remains supportive of Incanthera.

Capital subscription post period end

 

The Company has undertaken a successful fundraising post period ended; see the
separate announcement issued today.

 

Current Activities and Outlook

 

"We continue to make positive progressive steps for ImmuPharma. As a Board, we
remain focused on bringing our two key late stage P140 clinical assets in
Lupus and CIDP through their final clinical trials and to the market.

The drive to conclude further commercial and partnering deals will be
accelerated over this next period and which is now bolstered by the recently
announced new Board appointments.

The Board would like to take this opportunity to thank its shareholders for
their continued patience and support, as well as its staff, corporate and
scientific advisers and our partners including CNRS and Avion."

 

 

Tim
McCarthy

Chairman & Chief Executive Officer

 

31 August 2023

ImmuPharma plc

 

CONSOLIDATED INCOME STATEMENT
FOR THE PERIOD ENDED 30 JUNE 2023

 

                                              Unaudited          Audited Year ended 31 December 2022      Unaudited 6 months ended

                                              6 months ended                                              30 June 2022

                                              30 June 2023

                                       Note
                                              £                  £                                        £
 Continuing operations
 Revenue                                      69,959                   -                                  -
 Research and development expenses            (828,767)          (2,022,507)                              (1,042,917)
 Administrative expenses                      (412,277)          (846,571)                                (555,600)
 Share based expense                          (127,327)          (159,874)                                (70,994)

                                              (1,298,412)        (3,028,952)                              (1,669,511)

 Operating loss

 Finance costs                         6      (931)              (1,455,966)                              (176,665)
 Finance income                               162,286            (28,585)                                 16,364

 Loss before taxation                         (1,137,057)        (4,456,333)                              (1,829,812)

 Tax                                          289,691            648,902                                  166,024

 Loss for the period                          (847,366)          (3,807,431)                              (1,663,788)

 Attributable to:
 Equity holders of the parent company         (847,366)          (3,807,431)                              (1,663,788)

 Loss per ordinary share

 Basic and diluted                     2      (0.25)p            (1.26)p                                  (0.58)p

 

 

 

ImmuPharma plc

 

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIOD ENDED 30 JUNE 2023

 

 

                                                                           Unaudited          Audited Year                   Unaudited 6 months ended

                                                                           6 months ended      ended 31 December 2022        30 June

                                                                           30 June                                           2022

                                                                           2023
                                                                           £                  £                              £

 Loss for the financial period                                             (847,366)          (3,807,431)                    (1,663,788)

 Other comprehensive income
 Items that will not be reclassified subsequently to profit or loss:

 Fair value loss on investment                                             (54,474)           (519,977)                      (614,068)
 Fair value loss on warrants                                               7,421              (206,279)                      (206,411)

 Total items that will not be reclassified subsequently to profit or loss  (47,053)           (726,256)                      (820,479)

 Items that may be reclassified subsequently to profit or loss:

 Exchange differences on translation of foreign operations                 (18,897)           79,104                         16,350

 Total items that may be reclassified subsequently to profit or loss       (18,897)           79,104                         16,350

 Other comprehensive loss for the period

                                                                           (65,950)           (647,152)                      (804,129)

 Total comprehensive loss for the period                                   (913,316)          (4,454,583)                    (2,467,917)

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION
AS AT 30 JUNE 2023
                                                                                                                                             Note  Unaudited              Audited Year                 Unaudited 6 months ended

                                                                                                                                                   6 months ended         ended 31 December 2022       30 June

                                                                                                                                                   30 June                                             2022

                                                                                                                                                   2023
                                                                                                                                                   £                      £                            £
 Non-current assets
 Intangible assets                                                                                                                                 463,207                473,892                      471,534
 Property, plant and equipment                                                                                                                     332,992                389,716                      330,835

 Financial                                                                                                                                         642,526                689,579                      595,355
 asset
 Derivative financial asset                                                                                                                  4     36,466                 82,563                       196,488

 Total non-current assets                                                                                                                          1,475,191              1,635,750                    1,594,212

 Current assets
 Trade and other receivables                                                                                                                       705,867                723,583                      114,450
 Cash and cash equivalents                                                                                                                         210,584                667,813                      170,922
 Current tax asset                                                                                                                                 624,429                695,297                      595,205
 Derivative financial asset                                                                                                                  4     272,388                252,258                      400,306

 Total current assets                                                                                                                              1,813,268              2,338,951                    1,280,883

 Current liabilities
 Financial liabilities - borrowings                                                                                                                -                      (111)                        (230)
 Trade and other payables                                                                                                                          (1,551,071)            (1,451,213)                  (858,291)

 Total current liabilities                                                                                                                         (1,551,071)            1,451,324)                   (858,521)

 Net current assets                                                                                                                                262,197                887,627                      422,362

 Net assets                                                                                                                                        1,737,388              2,523,377                    2,016,574

 EQUITY
 Ordinary shares                                                                                                                             5     28,982,676             28,982,676                   28,498,94
 Share premium                                                                                                                                     28,788,377             28,788,377                   27,237,329
 Merger reserve                                                                                                                                    106,148                106,148                      106,148
 Other reserves                                                                                                                                    5,869,926              5,761,496                    5,240,503
 Retained earnings                                                                                                                                 (62,009,739)           (61,115,320)                 (59,065,900)

 Total equity                                                                                                                                      1,737,388              2,523,377                    2,016,574

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY
FOR THE PERIOD ENDED 30 JUNE 2023
                                                       Ordinary shares                                                                                                                         Other reserves -Share based payment reserve                                                               Total

                                                       £                                                                                                                                       £                                                                                                         Equity

                                                                                                                                                                                                                                                                                                         £

                                                                                                                              Other              Other                                                                                          Other reserves - Warrant reserve

                                                                                                                               reserves -        reserves -                                                                                     £

                                                                              Share premium                     Merger        Acquisition        Translation                                                                                                                           Retained

                                                                                           £                    Reserve       Reserve            Reserve                                                                                                                               Earning

                                                                                                                £             £                  £                                                                                                                                     £s
     At 1 January 2022                                     28,498,494         27,237,329                        106,148       (3,541,203)        (1,344,657)                                   8,690,019                                        1,349,000                              (56,581,633)      4,413,497
     Loss for the financial period                     -                      -                                 -             -                  -                                             -                                                -                                      (1,663,788)       (1,663,788)
     Exchange differences                                                                                                                                16,350                                                                                 -                                                        16,350

                                                       -                      -                                 -             -                  -                                             -                                                                                       -
     Share based payments                              -                      -                                 -             -                  -                                             70,994                                           -                                      -                         70,994
     Fair value loss on investments                    -                      -                                 -             -                  -                                             -                                                -                                      (614,068)         (614,068)
     Fair value loss on warrants                       -                      -                                 -             -                  -                                             -                                                -                                      (206,411)         (206,411)
     At 30 June 2022 unaudited                         28,498,494             27,237,329                        106,148       (3,541,203)        (1,328,307)                                   8,761,013                                        1,349,000                              (59,065,900)      2,016,574

     At 1 January 2022                                     28,498,494         27,237,329                        106,148       (3,541,203)        (1,344,657)                                   8,690,019                                        1,349,000                              (56,581,633)      4,413,497
     Loss for the financial year                       -                      -                                 -             -                                      -                         -                                                                                       (3,807,431)       (3,807,431)
     Exchange differences                              -                                                        -             -                            79,104                              -                                                -                                      -                 (79,104)

     Share based payments                              -                      -                                 -             -                  -                                             159,874                                          -                                      -                 159,874
     New issue of equity capital                       484,182                1,866,727                         -             -                  -                                             -                                                -                                      -                 2,350,909
     Cost of new issue of equity capital               -                      (165,679)                         -             -                  -                                             -                                                -                                      -                 (165,679)
     Fair value loss on investments                    -                      -                                 -             -                  -                                             -                                                -                                      (519,977)         (519,977)
     Fair value loss on warrants                       -                      -                                 -             -                  -                                             -                                                -                                      (206,279)         (206,279)
     Issue of warrants                                                        (150,000)                                                                                                                                                         369,359                                -                 219,359
     At 31 December 2022 & 1 January 2023 audited          28,982,676         28,788,377                        106,148       (3,541,203)        (1,265,553)                                   8,849,893                                        1,718,359                              (61,115,320)      2,523,377

     Loss for the financial period                     -                      -                                 -             -                  -                                             -                                                -                                      (847,366)         (1,663,788)
     Exchange differences                                                                                                                                                                                                                                                                                16,350

                                                       -                      -                                 -             -                  (18,897)                                      -                                                                                       -

     Share split                                       -                                                                                                                                                                                                                                                 -
     Share based payments                              -                      -                                 -             -                  -                                             127,327                                          -                                      -                         70,994
     Fair value loss on investments                    -                      -                                 -             -                  -                                             -                                                -                                      (54,475)          (614,068)
     Fair value gain on warrants                       -                      -                                 -             -                  -                                             -                                                -                                      7,421             (206,411)
     At 30 June 2023 unaudited                         28,982,676             28,788,377                        106,148       (3,541,203)        (1,284,450)                                   8,977,220                                        1,718,359                              (62,009,739)      1,737,388

ImmuPharma plc

 

CONSOLIDATED STATEMENT OF CASHFLOWS
FOR THE PERIOD ENDED 30 JUNE 2023

 

                                                         Note                                     Unaudited            Audited Year                                  Unaudited 6 months ended

                                                                                                  6 months ended       ended 31 December 2022                        30 June

                                                                                                  30 June                                                            2022

                                                                                                  2023
                                                                                                  £                    £                                             £
 Cash flows from operating activities
 Cash used in operations                                 3                                        (990,977)            (3,224,906)                                   (1,966,598)
                                                                                                  338,992                               879,877                      343,246

 Tax received
 Interest paid                                                                                    (932)                         (2,036)                              (922)

                                                                                                  (652,917)            (2,347,065)                                   (1,624,274)

 Net cash used in operating activities

 Investing activities
 Purchase of property, plant and equipment                                                        -                             (106,009)                            -
 Interest received                                                                                1,464                      28,585                                  63

 Net cash (used in)/generated from investing activities                                           1,464                     (77,424)                                 63

 Financing activities
 Decrease in bank overdraft                                                                       (109)                            -                                 -
 New loans/(loan repayments)                                                                      -                          -                                       (470)
 Settlements from Sharing Agreement                                                               184,951              362,500                                       143,273
 Gross proceeds from issue of new share capital                                                   -                    2,350,909                                     -
 Share capital issue costs                                                                        -                    (165,679)                                     -
 Funds deferred per Sharing Agreement                                                             -                    (1,000,000)                                   -

 Net cash generated from financing activities                                                     184,842              1,547,730                                     142,803

 Net (decrease) in cash and cash equivalents                                                      (466,612)            (876,759)                                     (1,481,408)

 Cash and cash equivalents at start of period                                                     667,813              1,649,374                                     1,649,374

 Effects of exchange rates on cash and                                                                  9,382          (104,802)                                     2,956

 cash equivalents

                                                                                                                       667,813

 Cash and cash equivalents at end of period                                                       210,583                                                            170,922

ImmuPharma plc

 
NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

 

1          ACCOUNTING POLICIES

 

Basis of preparation

 

The interim financial information in this report has been prepared using
accounting policies consistent with IFRS as adopted by the United Kingdom.
IFRS is subject to amendment and interpretation by the International
Accounting Standards Board (IASB) and the IFRS Interpretations Committee and
there is an ongoing process of review and endorsement by the UK Endorsement
Board. The financial information has been prepared on the basis of IFRS
expected to be adopted by the United Kingdom and applicable as at 31 December
2022. The Group has chosen not to adopt IAS 34 "Interim Financial Statements"
in preparing the interim financial information.

 

The accounting policies applied are consistent with those that were applied to
the financial statements for the year ended 31 December 2022.

 

             Non-Statutory accounts

 

The financial information set out in this interim report does not constitute
the Group's statutory accounts, within the meaning of Section 434 of the
Companies Act 2006. The statutory accounts for the year ended 31 December 2022
have been filed with Registrar of Companies. The auditors reported on those
accounts; their report was unqualified, did not contain a statement under
either Section 498 (2) or Section 498 (3) of the Companies Act 2006 but did
include emphasis of matter paragraph relating to the carrying value of Parent
Company's investment in subsidiaries and receivables due from group
undertakings, and a reference to which the auditor drew attention by way of
emphasis without qualifying their report in respect of going concern.

 

 

 

 

 

 

 

ImmuPharma plc

 
NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023
(Continued)

 

 

2              LOSS PER SHARE

 

 

                                                                                Unaudited          Audited Year                 Unaudited 6 months ended

                                                                                6 months ended     ended 31 December 2022       30 June

                                                                                30 June                                         2022

                                                                                2023
                                                                                £                  £                            £

 Loss
 Loss for the purposes of basic and diluted loss per share being net loss       (847,366)          (3,807,431)                  (1,663,788)
 attributable to equity shareholders

 Number of shares
 Weighted average number of ordinary shares for the purposes of basic loss per  333,403,115        302,912,903                  284,984,933
 share

                                                                                (0.25)p            (1.26)p                      (0.58)p

 Basic loss per share

 Diluted loss per share                                                         (0.25)p            (1.26)p                      (0.58)p

There is no difference between basic loss per share and diluted loss per share
as the share options and warrants are anti-dilutive. Deferred shares are
excluded from the loss per share calculation as they have no attributable
earnings.

 

 

ImmuPharma plc

 
NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

 

(Continued)

 

 3                  CASH USED IN OPERATIONS
                                                                             Unaudited             Audited Year                  Unaudited 6 months ended

                                                                             6 months ended        ended 31 December 2022        30 June

                                                                             30 June                                             2022

                                                                             2023
                                                                             £                     £                             £

    Operating loss                                                           (1,298,417)           (3,028,952)                   (1,669,511)
    Depreciation & amortisation                                              58,787                117,563                                 86,639
    Share based payments                                                     127,327               159,874                              288,826
    Decrease/(increase) in trade & other receivables                         17,716                (132,392)                     312,749
    Increase/(decrease) in trade & other payables                            99,858                (296,384)                     (725,313)
    Gain / (loss) on foreign exchange                                        3,752                 (45,554)                      7,271

    Cash used in operations                                                  (990,977)             (3,224,906)                   (1,966,598)

 

 

 

 4    Derivative Financial Asset

      As part of the placement completed in March 2020, the Company issued

    13,000,000 new ordinary shares to Lanstead Capital Investors L.P. ("Lanstead")
      at a price of 10p per share for an aggregate subscription price of £1.3m
      before expenses. In December 2021, the Company issued 20,000,000 new ordinary
      shares to Lanstead at a price of 11p per share to raise £2.2m before
      expenses. In the placement completed in August 2022, the Company issued
      20,000,000 new ordinary shares to Lanstead at a price of 5p per share to raise
      £1m gross. All Subscriptions proceeds were pledged under Sharing Agreements,
      under which Lanstead made and will continue to make, subject to the terms and
      conditions of the respective Sharing Agreement, monthly settlements to the
      Company that are subject to adjustment upwards or downwards depending on the
      Company's share price performance.

      In December 2021 and August 2022 the Company also issued 1,400,000 new
      ordinary shares consecutively to Lanstead as value payments in connection with
      the Share Subscriptions and the Sharing Agreements. Monthly settlements under
      the Sharing Agreement from March 2020 completed in June 2022. The settlements
      from remaining Sharing Agreements (December 2021 and August 2022) will
      continue until 2024, completing in March 2024 and August 2024 respectively.

      At the end of the accounting period the amount receivable has been adjusted to
      fair value based upon the share price of the Company at that date. Any change
      in the fair value of the derivative financial asset is reflected in the income
      statement. As at 30 June 2023, the Company completed a calculation of fair
      value of the derivative financial asset that resulted in a finance gain of
      £142,439 (£174,742 loss at 30 June 2022), which was recorded in the income
      statement. The restatement to fair value will be calculated at the end of each
      accounting period during the course of each Sharing Agreement and will vary
      according to the Company's share price performance.

 

 

 

ImmuPharma plc

 
NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2023

 

(Continued)

 

 

5              Issued share capital

 

At 30 June 2023, the Company had no limit on its authorised share capital.

 

 Allotted, called up and fully paid  30 June 2023 No.  31 December 2022 No.  30 June 2023 £   31 December

                                                                                              2022 £
 At start of year:
 Ordinary shares of £0.10 each
 Ordinary shares of £0.01 each       333,403,115       284,984,933           3,334,032        2,849,849
 Deferred shares of £0.09 each       284,984,933       284,984,933           25,648,644       25,648,644
 Movements during period:
 Shares issued on 23 December 2021
 Shares issued on 16 August 2022     -                 42,418,182            -                424,183
 Shares issued on 30 August 2022     -                 1,000,000             -                10,000
 Shares issued on 5 September 2022   -                 2,000,000             -                20,000
 Shares issued on 13 September 2022  -                 3,000,000             -                30,000
 At end of the period                618,388,048       618,388,048           28,982,676       28,982,676

 

 

 

 

 

6.             Subsequent events

 

Successful fundraising, see separate announcement issued today

 

 

 

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