** Brokerage Wedbush Securities downgrades Impel
Pharmaceuticals Inc IMPL.O to "neutral" from "outperform",
cuts PT to $5 from $24
** Wedbush lowers revenue estimates for company's migraine
drug, Trudhesa, citing "pricing improvements taking longer to
materialize" and lower-than-expected demand for the drug
** Commercial traction "remains elusive" for the drug in
migraine space - brokerage
** Expansion of sales force may increase drug's uptake,
however, this will increase pressure on company's cash runway -
Wedbush
** Cowen and Co also trims PT on IMPL to $40 from $55
** As of last close, stock down ~61% YTD
(Reporting by Raghav Mahobe)
((Raghav.Mahobe@thomsonreuters.com))