REG - IQ-AI Limited - IQ-AI Announces Positive Interim Phase 1 Results

IQ-AIAnnouncement

05/12/2023 11:00

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RNS Number : 7354V  IQ-AI Limited  05 December 2023

IQ-AI Ltd

("IQ-AI" or the "Company")

IQ-AI Announces Positive Interim Phase 1 Results

On-going trial to study the safety of oral gallium maltolate in relapsed GBM
patients

·    All three planned dose levels tested to date continue to exhibit
favorable safety and tolerability

·    Patients report no adverse effects, side effects, or symptoms

·    An amendment to the study protocol is approved for dose escalation

Imaging Biometrics, LLC (IB), a wholly owned subsidiary of IQ-AI Ltd (LSE:
IQAI), is pleased to update shareholders with additional positive details on
the on-going study of oral gallium maltolate, an investigational monotherapy
for the treatment of recurrent/refractory glioblastoma (GBM). These
preliminary results were recently presented by the study PI, Dr. Jennifer
Connelly, MD, at the Society for Neuro-Oncology (SNO) 28th Annual Meeting held
November 15-19 in Vancouver.

Seventeen patients have met the eligibility criteria and have enrolled in the
phase 1 component of the study. As of 30 November 2023, of the fourteen
patients evaluable for treatment with oral GaM, three patients have achieved a
median progression-free survival (PFS) of greater than 180 days, with 1
patient on treatment for greater than one year. This compares favorably with
the 1.5 to 6-month range historically reported for progression-free survival
in this population of relapsed GBM.

Patients enrolled in the study have all received prior treatments with some
experiencing multiple episodes of cancer recurrence. Historically, following
GBM recurrence, patients have a median overall survival (OS) of 2-9 months.

"We are encouraged by the favorable safety and tolerability profile at all
dose levels," said Dr. Christopher Chitambar, MD, Chair of the study. "Other
pre-clinical studies have been conducted that demonstrate that oral gallium
maltolate may prove to be a viable treatment alternative across multiple solid
tumors as well."

"This is an encouraging update and I am pleased with the steady progress being
made by the team" said Trevor Brown, CEO of IQ-AI.

--ENDS-

 

The Directors of the Company accept responsibility for the contents of this
announcement.

 

For further information, please contact:

 

 IQ-AI Ltd

 Trevor Brown/Vinod Kaushal/Brett Skelly/Michael Schmainda

 Tel: 020 7469 0930
 Peterhouse Capital Limited (Financial Adviser and Broker)

 Lucy Williams/Heena Karani

 Tel: 020 7220 9797

 

About Imaging Biometrics® LLC:  IB is a wholly owned subsidiary of IQ-AI
Limited, (LON: IQAI), and focuses on delivering quantitative imaging platforms
and therapeutics that transform how clinicians diagnose and treat patients
more efficiently and effectively. For more information about Imaging
Biometrics, visit the company's website at www.imagingbiometrics.com
(http://www.imagingbiometrics.com/) . Follow IB on Twitter, @IQAI_IB.

 

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