Updates
** Shares of weight-loss drug developer Kailera Therapeutics KLRA.O jump as much as 64.1% in Nasdaq debut
** Stock opens at $26 apiece versus $16 offer price
** Waltham, Massachusetts-based KLRA sold 39.1 million shares in an upsized IPO at top end of $14-$16 apiece marketed range to raise $625 million
** Demand for weight-loss drugs has skyrocketed in recent years, with the market expected to generate about $150 billion in annual sales over the next decade
** Kailera's lead product candidate ribupatide is in late-stage trials as a once-weekly injectable GLP-1 drug
** Obesity, GLP-1 drug developers continue to fetch high takeover premiums, as seen with the recent acquisition of Metsera by Pfizer - IPOX Research Associate Lukas Muehlbauer
** J.P. Morgan, Jefferies, Leerink Partners, TD Cowen, Evercore ISI acted as joint book-running managers for offering
(Reporting by Arasu Kannagi Basil in Bengaluru)
((ArasuKannagi.Basil@thomsonreuters.com;))