** H.C. Wainwright lowers drug developer Karuna Therapeutics
Inc's KRTX.O PT to $300 from $320 citing dilution impact from
a stock sale
** Co last week sold ~2.5 mln shares at $161.33, raising
$400 mln to fund its lead experimental schizophrenia drug, KarXT
** Brokerage expects KRTX to end Q1'23 with over $1.4 bln in
cash, cash equivalents and short-term marketable investments
** KRTX recently also reported KarXT, significantly reduced
symptoms of schizophrenia in a late-stage trial, but
hypertension concerns weighed
** H.C. Wainwright optimistic on the drug saying the
efficacy profile in totality seems to set a new standard in
schizophrenia, with broad impact across multiple symptom
categories
** Increases its approval probability for the drug to 90% vs
prior assumption of 85%
** Sees co to file for approval of KarXT in mid-2023, with
possible approval in H2'24
** Adds it conservatively, only expect revenue from sales of
KarXT to begin during 2025
** In 2022, KRTX stock was up 50%
(Reporting by Pratik Jain in Bengaluru)
((Pratik.Jain@thomsonreuters.com;))