Karyopharm Therapeutics to cut workforce by 20%; shares fall
** Drugmaker Karyopharm Therapeutics' shares KPTI.O down 15.8% at $4.21 premarket ** Company says in an SEC filing it is reducing its workforce by 20% ** Company expects its one-time expenses in connection with these actions to be immaterial ** Co says board is evaluating financing and strategic alternatives ** As of last close, stock down 50.7% YTD (Reporting by Siddhi Mahatole) ((siddhi.mahatole@thomsonreuters.com))