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Graphite Bio rises on job cuts, exploring strategic alternatives

** Shares of drug developer Graphite Bio Inc  GRPH.O  rise
~9% to $2.4 premarket 
    ** Co said late on Wednesday it completed a review of its
business and will initiate a process to explore strategic
alternatives
    ** GRPH board has decided to reduce workforce by ~50% as
part of corporate restructuring to reduce cash burn
    ** Expects to incur estimated severance and related costs of
about $4.9 mln, which will be recorded in Q2 2023
    ** Co has decided to discontinue further development of its
treatment for sickle cell disease, says is exploring potential
to continue nula-cel development externally
    ** As of Dec 31, 2022, co had a preliminary unaudited
~$283.5 million in cash, cash equivalents and investments in
marketable securities
    ** Co lost ~73% in 2022
 (Reporting by Sriparna Roy)
 ((Sriparna.Roy@thomsonreuters.com;))

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