** Metis TechBio 7666.HK jumps 144.8% from HK$10.50 offer price in Hong Kong debut, seventh most active stock by turnover
** AI-driven nanotech developer's shares earlier hit HK$29.98; Hang Seng .HSI gains 0.3%
** 74.6 mln shares worth HK$2.16 bln ($276 mln) traded so far
** Co raised HK$2.11 bln for R&D, clinical trials in global offering
** Hong Kong public offering portion was 6,910.96x subscribed, international portion is 33.86x subscribed
** IMPACT Therapeutics 7630.HK also debuts strong, up 111.9% from HK$20.10 offer price after 123.9% peak
** China biotech firm raised HK$844 mln for clinical development
** Hong Kong public offering portion was 2,282.4 times subscribed, international portion is 24.58 times
($1 = 7.8281 Hong Kong dollars)
(Reporting by Donny Kwok)
((donny.kwok@thomsonreuters.com))