RCS - PinCell - PinCell's Mouse Model; Appoints Dr. Antonino Amato
18/01/2023 19:30
For best results when printing this announcement, please click on link below: http://newsfile.refinitiv.com/getnewsfile/v1/story?guid=urn:newsml:reuters.com:20230118:nRSR1882Na&default-theme=true RNS Number : 1882N PinCell 18 January 2023 PinCell announces the development of a key transgenic mouse model and the appointment of Dr. Antonino Amato as CEO The biotechnology company has established a promising in-vivo platform for the development of its lead therapy, a monoclonal antibody that stops blistering in chronic skin conditions without suppressing the immune system. January 19, 2023 - MILAN - PinCell (http://www.pincell.it/) , a biotechnology company developing a first-in-class therapy for rare and debilitating autoimmune skin blistering diseases, has announced the generation of a transgenic mouse model that will provide an effective in-vivo platform for the development of its lead candidate. This innovative therapy is a fully human anti-FasL monoclonal antibody that stops blistering, without suppressing the immune system, thus avoiding side effects typical of immune-suppressant treatments. In two independent studies, PinCell's lead candidate has shown the reduction or the prevention of the formation of blisters in ex-vivo human models of pemphigus. The new mouse model will allow the production of in-vivo proof of concept data and the development of a solid understanding of how the antibody's blockade of excess human soluble Fas ligand relates to the effective treatment of pemphigus. The company's newly appointed Chief Executive Officer, Dr. Antonino (Tony) Amato, said PinCell's transgenic mouse model will provide "the icing on the cake" on what has been proven so far. "The mouse genome was modified so that mice would produce the human FasL protein, allowing the use of our human antibody against it, by selectively recognizing the human form of such a protein. The humanized FasL mouse model is a valuable tool to study the involvement of the Fas/FasL pathway also in other diseases in which this pathway may play a key role in disease development and progression." Pemphigus is a rare condition that affects about 330,000 patients worldwide. Conservatively, a treatment based on PC111 would be beneficial for over 30 percent of this population who are relapsing or refractory to first line treatments. PinCell's therapy will be an alternative to steroids or immunosuppressants currently prescribed or under development. By acting downstream to the immune system, at the level of skin cells, this new mode of action will contribute to the reduction or the avoidance of steroids/immunosuppressants. Luigi Costa, Chairman of PinCell's Board of Directors, commented: "We are pleased to welcome Tony during this important time in the company's development. He brings to PinCell a very relevant expertise in drug development and the leadership needed to guide the company to accelerate the development of our lead therapeutic candidate." ### About PinCell PinCell is a biotechnology company targeting a novel pathological pathway to develop first-in-class anti-inflammatory therapies for the treatment of rare, severe and highly undertreated skin diseases. Based in Milan, Italy, PinCell was founded in October 2008 as an academic spin-off of the University of Modena and Reggio Emilia by the world-class dermatology experts Prof. Carlo Pincelli and Prof. Alessandra Marconi. PinCell received seed funding from Sofinnova Partners. For more information, please visit: www.pincell.it (http://www.pincell.it) Contact: Tony Amato CEO, PinCell a.amato@pincell.com (mailto:a.amato@pincell.com) +39-334-6263471 This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com (mailto:rns@lseg.com) or visit www.rns.com (http://www.rns.com/) . Reach is a non-regulatory news service. By using this service an issuer is confirming that the information contained within this announcement is of a non-regulatory nature. Reach announcements are identified with an orange label and the word “Reach” in the source column of the News Explorer pages of London Stock Exchange’s website so that they are distinguished from the RNS UK regulatory service. Other vendors subscribing for Reach press releases may use a different method to distinguish Reach announcements from UK regulatory news. RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy (https://www.lseg.com/privacy-and-cookie-policy) . END NRAMZGMMRRKGFZM