BioNTech falls after terminating colorectal cancer trial

Moderna

28/08/2026 14:40

** U.S.-listed shares of German drugmaker BioNTech BNTX.O 22UAy.DE fall 8.6% to $101.84
** Shares of fellow mRNA drugmaker Moderna MRNA.O fall 5.2% to $135.37 
** Co terminates mid-stage trial of its experimental personalized mRNA treatment autogene cevumeran in patients with high-risk colorectal cancer who had undergone surgery
** Says independent monitors found a numerical imbalance in overall survival between patients receiving the treatment and those under watchful waiting, and concluded that continuing the trial was unlikely to change the outcome
** Does not disclose which group had worse survival, but says no new safety concerns were found
** Says a separate trial testing the treatment with other cancer medicines in pancreatic cancer will continue as planned; treatment is being jointly developed with Roche's ROPC.S Genentech unit
** Including session's moves, BNTX up 7.9% YTD 

(Reporting by Kunal Das in Bengaluru)
((Kunal.Das2@thomsonreuters.com;))