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REG-FORM 8.1(a) & (b) - Mural Oncology plc

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FORM 8.1(a) & (b)
(Opening Position Disclosure)

IRISH TAKEOVER PANEL

OPENING POSITION DISCLOSURE UNDER RULE 8.1(a) AND (b) OF THE IRISH TAKEOVER
PANEL ACT, 1997, TAKEOVER RULES, 2022 BY AN OFFEROR OR AN OFFEREE

1.      KEY INFORMATION

 (a) Full name of discloser:                                                                                                                                                                                                     Mural Oncology plc  
 (b) Owner or controller of interests and short positions disclosed, if different from 1(a):  The naming of nominee or vehicle companies is insufficient. For a trust, the trustee(s), settlor and beneficiaries must be named.  N/A                 
 (c) Name of offeror/offeree in relation to whose relevant securities this form relates:  Use a separate form for each offeror/offeree                                                                                           Mural Oncology plc  
 (d) Is the discloser the offeror or the offeree?                                                                                                                                                                                Offeree             
 (e) Date position held:  The latest practicable date prior to the disclosure                                                                                                                                                    29 April 2025       
 (f) In addition to the company in 1(c) above, is the discloser also making disclosures in respect of any other party to the offer?  If it is a cash offer or possible cash offer, state “N/A”                                   N/A                 

2.      INTERESTS AND SHORT POSITIONS

If there are interests and positions to disclose in more than one class of
relevant securities of the offeror or offeree named in 1(c), copy table 2 for
each additional class of relevant security.

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Interests and short positions in the relevant securities of the offeror or
offeree to which the disclosure relates (Note 1)

 Class of relevant security: (Note 2)                                                                                    
                                                                                      Interests      Short positions     
                                                                                      Number  %      Number    %         
 (1) Relevant securities owned and/or controlled:                                     NIL     -      NIL       -         
 (2) Cash-settled derivatives:                                                        NIL     -      NIL       -         
 (3) Stock-settled derivatives (including options) and agreements to purchase/ sell:  NIL     -      NIL       -         
 Total:                                                                               NIL     -      NIL       -         

All interests and all short positions should be disclosed.

Details of options including rights to subscribe for new securities and any
open stock-settled derivative positions (including traded options), or
agreements to purchase or sell relevant securities, should be given on a
Supplemental Form 8.

3.      INTERESTS AND SHORT POSITIONS OF PERSONS ACTING IN CONCERT WITH
THE PARTY MAKING THE DISCLOSURE

 Details of any interests and short positions (including directors’ and other employee options) of any person acting in concert with the party making the disclosure:                                                                                                                                                                                 
 a)                         The directors of the Offeree detailed in the table below (together with their connected persons under Rule 3.3(b)(ii) of Part A of the Irish Takeover Rules) have the following interests in the Offeree                                                                                                                  
 Director                   Class of Relevant Security                 Number of ordinary shares held at midnight on 29 April 2025  Percentage of total issued share capital (rounded)                                    Total number of ordinary shares underlying outstanding stock options, restricted share units and other subscription rights  
 Caroline Loew              Ordinary shares of US$0.01 each            43,622                                                       0.25%                                                                                 865,908                                                                                                                     
 Scott Jackson              Ordinary shares of US$0.01 each            ꟷ                                                            ꟷ                                                                                     23,483                                                                                                                      
 Francis Cuss               Ordinary shares of US$0.01 each            ꟷ                                                            ꟷ                                                                                     23,483                                                                                                                      
 George Stanley Golumbeski  Ordinary shares of US$0.01 each            ꟷ                                                            ꟷ                                                                                     15,334                                                                                                                      
 Benjamin Hickey            Ordinary shares of US$0.01 each            ꟷ                                                            ꟷ                                                                                     23,483                                                                                                                      
 Sachiyo Minegishi          Ordinary shares of US$0.01 each            ꟷ                                                            ꟷ                                                                                     15,335                                                                                                                      
 TOTAL                      -                                          43,622                                                       0.25%                                                                                 967,026                                                                                                                     

Details of any open stock-settled derivative positions (including traded
options), or agreements to purchase or sell relevant securities, should be
given on a Supplemental Form 8.

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4.      OTHER INFORMATION

(a)      Indemnity and other dealing arrangements

 Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the party to the offer making the disclosure or any person acting in concert with it:  
                                                                                                                                                                                                                                                                                                          
 Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state “none”                                                                                                                                                      
 None                                                                                                                                                                                                                                                                                                     

(b)      Agreements, arrangements or understandings relating to options
or derivatives

 Full details of any agreement, arrangement or understanding between the person disclosing and any other person relating to the voting rights of any relevant securities under any option referred to on this form or relating to the voting rights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form is referenced. If none, this should be stated.  
 None                                                                                                                                                                                                                                                                                                                                                                                                             

(c)      Attachments

 Is a Supplemental Form 8 attached?  YES/NO  
                                     No      



 Date of disclosure:  30 April 2025         
 Contact name:        Maiken Keson-Brookes  
 Telephone number:    +1 781 614 0239       

Public disclosures under Rule 8.1 of the Rules must be made to a Regulatory
Information Service.

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NOTES ON FORM 8.1(a) and (b)

1.         See the definition of “interest in a relevant security” in
Rule 2.5 of Part A of the Rules and see Rule 8.6(a) of Part B of the Rules.

2.         See the definition of “relevant securities” in Rule 2.1 of
Part A of the Rules.

3.      If details included in a disclosure under Rule 8 are incorrect,
they should be corrected as soon as practicable in a subsequent disclosure.
Such disclosure should state clearly that it corrects details disclosed
previously, identify the disclosure or disclosures being corrected, and
provide sufficient detail for the reader to understand the nature of the
corrections. In the case of any doubt, the Panel should be consulted.

For full details of disclosure requirements, see Rule 8 of the Rules. If in
doubt, consult the Panel.

References in these notes to “the Rules” are to the Irish Takeover Panel
Act, 1997, Takeover Rules, 2022

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