REG - Ondine Biomedical - First commercial adoption of Steriwave by the NHS

Ondine BiomedicalAnnouncement

25/03/2024 07:00

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RNS Number : 0619I  Ondine Biomedical Inc.  25 March 2024

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25 March 2024

ONDINE BIOMEDICAL INC.

("Ondine Biomedical", "Ondine", or the "Company")

First commercial adoption of Steriwave by the NHS

NHS deal gives patients access to groundbreaking light-activated antimicrobial
to combat AMR (antimicrobial resistance)

·      A new light-activated antimicrobial that kills all types of bugs
- viruses, bacteria, and fungi - in minutes without generating resistance is
being adopted by two NHS hospitals to reduce surgical infections.

Mid Yorkshire Teaching NHS Trust has approved the commercial adoption of
Ondine's groundbreaking light-activated antimicrobial, Steriwave®. The
approval will see the use of Steriwave expanded across hip and knee surgery
patients at Pontefract and Pinderfields NHS Hospitals to reduce the incidence
of surgical site infections (SSIs). This adoption as standard-of-care for
orthopedic patients follows a successful, initial deployment that is being
used to evaluate Steriwave at Pontefract Hospital.

Dr Stuart Bond, Consultant antimicrobial pharmacist and Director of Innovation
at Mid Yorkshire Teaching NHS Trust, commented:

"We are very pleased to be the first NHS Trust to be giving patients access to
this important new technology. SSIs can have a devastating effect on patients
and their families, and we are pleased that we have demonstrated the
feasibility of using Steriwave in our Orthopaedic Centre of Excellence at
Pontefract Hospital. It is a real step forward to making Steriwave more widely
available across the Trust."

The CEO of Ondine Biomedical, a world leader in light-activated antimicrobial
technology, Carolyn Cross, said:

"We are delighted to see the first two NHS hospitals adopt Steriwave,
particularly as NHS is seen around the world as a leader in antibiotic
stewardship in response to the growing threat of AMR (antimicrobial
resistance). This is not only a significant milestone for Ondine, but Mid
Yorks's accelerated decision to adopt suggests that Steriwave has been well
received by patients, surgeons, and nurses."

As announced on 5 March 2024, Ondine Biomedical, Mid Yorkshire Teaching NHS
Trust, and Health Innovation Yorkshire & Humber have partnered to sponsor
a health economic analysis with the York Health Economics Consortium (YHEC).
The full findings of this study [are expected to be reported on later this
year and] will be used to support the further spread and adoption of Steriwave
across the NHS and across additional surgical applications.

SSIs are one of the most common healthcare-associated infections (HAIs) and
affect one in every 20 patients who undergo a surgical procedure in the
NHS. 1  SSIs can cost up to £100,000 per patient, 2  and the overall cost of
HAIs to NHS England is over £2 billion a year. 3  These costs are expected to
rise as growing rates of antimicrobial resistance (AMR) make the current
standard of care - the antibiotic mupirocin -  less effective. 4 

Steriwave is a light-activated antimicrobial that uses a specific wavelength
of red light to destroy pathogens that colonise the nose and can spread to
cause harmful infections. Crucially, unlike traditional antibiotics, Steriwave
is immediately effective with a single five-minute treatment and does not
trigger antimicrobial resistance (AMR). Nasal decolonization - eliminating
harmful pathogens from the nasal cavities - is recommended by WHO and NICE
prior to surgery as a key approach to preventing SSIs. 5 

Steriwave has been used in over 150,000 patient treatments, including at major
hospitals across Canada, including Vancouver General Hospital (VGH), The
Ottawa Hospital (TOH), and the Mazankowski Alberta Heart Institute. Research
recently published by VGH in the Canadian Journal of Surgery showed that the
use of Steriwave in patients undergoing spine surgery resulted in a 66.5%
reduction in post-surgical infection rates and almost $2600 per spine surgery
patient, representing $2.5 million in annual savings for Vancouver General
Hospital's spine group. 6  No serious adverse events have ever been reported
from Steriwave treatment.

**ENDS**

Enquiries:

 Ondine Biomedical Inc.
 Carolyn Cross, CEO                                           +001 (604) 665 0555
 Singer Capital Markets (Nominated Adviser and Joint Broker)
 Aubrey Powell, Asha Chotai, Sam Butcher                      +44 (0)20 7496 3000
 RBC Capital Markets (Joint Broker)
 Rupert Walford, Kathryn Deegan                               +44 (0)20 7653 4000
 Vane Percy & Roberts (Media Contact)
 Simon Vane Percy, Amanda Bernard                             +44 (0)77 1000 5910

 

About Ondine Biomedical Inc.

Ondine Biomedical Inc. is a Canadian life science company and a world leader
in the development and clinical use of light-activated antimicrobial therapies
(also known as 'photodisinfection'). Based on its proprietary light-activated
technology, Ondine has a pipeline of investigational products in various
stages of development.

Ondine's nasal decolonisation light-activated technology has a CE mark in
Europe and the UK and is approved in Canada and several other countries under
the name Steriwave®. In the US, it has been granted Qualified Infectious
Disease Product designation and Fast Track status by the FDA and is currently
undergoing clinical trials for regulatory approval. Light-activated
antimicrobial products in development include therapies for a variety of
medical indications such as chronic sinusitis, ventilator-associated
pneumonia, burns, and other indications.

About Steriwave®

Ondine's Steriwave is a patented technology using a proprietary
light-activated antimicrobial (photosensitizer) to destroy bacteria, viruses,
and fungi colonizing the nose - a major reservoir of pathogens. The treatment
is carried out by a trained healthcare professional and is an easy-to-use,
painless, two-step process. The photosensitizer is applied to each nostril
using a nasal swab, followed by illumination of the area with a specific
wavelength of red light for less than five minutes. The light activates the
photosensitizer, causing an oxidative burst that is lethal to all types of
pathogens without causing long-term adverse effects on the nasal microbiome. A
key benefit of this approach, unlike with antibiotics, which have resistance
rates reported as high as 81%( 7 ), is that pathogens do not develop
resistance to the therapy.

Nasal decolonization is recommended in the 2016 WHO Global guidelines for the
prevention of surgical site infections,( 8 ) and the Society for Healthcare
Epidemiology of America (SHEA) guidelines, published in May 2023, recommend
nasal decolonisation for major surgical procedures.( 9 )

 

 1  National Institute for Health and Care Excellence, Surgical site
infections: prevention and treatment NICE guideline  NG125 , 2019,
https://www.nice.org.uk/guidance/ng125/chapter/Context)

 2  Getting it Right First Time, SSI National Survey, April 2019,
https://gettingitrightfirsttime.co.uk/wp-content/uploads/2017/08/SSI-Report-GIRFT-APRIL19e-FINAL.pdf)

 3  Guest JF, Keating T, Gould D, et al Modelling the annual NHS costs
and outcomes attributable to healthcare-associated infections in England BMJ
Open 2020; 10:e033367. https://doi.org/10.1136/bmjopen-2019-033367
(https://doi.org/10.1136/bmjopen-2019-033367)

 4  Naylor NR, Evans S, Pouwels KB, Troughton R, Lamagni T, Muller-Pebody B,
Knight GM, Atun R, Robotham JV. Quantifying the primary and secondary effects
of antimicrobial resistance on surgery patients: Methods and data sources for
empirical estimation in England. Front Public Health. 2022 Aug 8;10:803943.
doi: 10.3389/fpubh.2022.803943. PMID: 36033764; PMCID: PMC9413182.

 5  https://www.nice.org.uk/guidance/ng125/chapter/recommendations
(https://www.nice.org.uk/guidance/ng125/chapter/recommendations)

 6  Eryck Moskven, Daniel Banaszek, Eric C. Sayre, Aleksandra Gara, Elizabeth
Bryce, Titus Wong, Tamir Ailon, Raphaële Charest-Morin, Nicolas Dea, Marcel
F. Dvorak, Charles G. Fisher, Brian K. Kwon, Scott Paquette and John T.
Street. Can J Surg November 15, 2023 66 (6) E550-E560; DOI:
https://doi.org/10.1503/cjs.016922 (https://doi.org/10.1503/cjs.016922)

 7  Poovelikunnel T, Gethin G, Humphreys H. Mupirocin resistance: clinical
implications and potential alternatives for the eradication of MRSA. J
Antimicrob Chemother. 2015;70(10):2681-2692. doi:10.1093/jac/dkv169

 8 
https://cdn.who.int/media/docs/default-source/integrated-health-services-(ihs)/ssi/fact-sheet-staphylococcus-web.pdf?sfvrsn=7e7266ed_2
(https://cdn.who.int/media/docs/default-source/integrated-health-services-(ihs)/ssi/fact-sheet-staphylococcus-web.pdf?sfvrsn=7e7266ed_2)

 9  Calderwood MS, Anderson DJ, Bratzler DW, et al. Strategies to prevent
surgical site infections in acute-care hospitals: 2022 Update. Infect Control
Hosp Epidemiol. 2023;44(5):695-720. doi:10.1017/ice.2023.67

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