REG - OptiBiotix Health - Results of cholesterol human volunteer study <Origin Href="QuoteRef">OPTIO.L</Origin>

OptiBiotix HealthAnnouncement

07/04/2016 07:05

RNS Number : 4332U
OptiBiotix Health PLC
07 April 2016
7 April 2016
OptiBiotix Health plc
("OptiBiotix"or "the Company")
 Results of cholesterol human volunteer study 
OptiBiotixHealthplc(AIM: OPTI),alifesciencesbusinessdevelopingcompoundstotackleobesity,high
cholesterolanddiabetes, announces that further to its announcement of successful humans studies on its capsular supplement to reduce cholesterol on 28 July 2015, more detail on the results of the study. 
The twelve week double blind placebo controlled study recruited fifty volunteers and was designed to establish safety, compliance, and the extent of the cholesterol lowering potential of OptiBiotix's Lactobacillus plantarum strain in mildly hypercholesterolaemic adults.
When volunteers taking placebo were compared to those taking OptiBiotix's capsular supplement the results showed a:-
 7.2% reduction in LDL cholesterol (bad cholesterol) averaged across the whole test group
 12.4% reduction in LDL cholesterol in females volunteers
 15% reduction in the 50-55 age groups (both sexes)
 36.7% reduction in volunteers' who had totalcholesterol levels higher than6mmol/L
 A 6mmHg (5.1%) reduction in systolic blood pressure averaged across the OptiBiotix group
No safety, compliance, or tolerance issues were reported by volunteers during the study in either group.
The results of this independent, blinded study provide early evidence that OptiBiotix's strain has commercial potential as a safe, easy to use, low cost, cholesterol reducing supplement. These results suggest efficacy across all volunteers similar or greater to 1.5 - 2.4 g plant sterols/stanols per day, and in volunteers with total cholesterol level greater than 6mmol/Lan efficacy more typically associated with pharmaceuticals. 
StephenO'Hara,CEOofOptiBiotix,commented:"We are really pleased with the results of this study which opens up opportunities for a single product for both conditions (high cholesterol and high blood pressure) or two different products targeting separate conditions. Given the market opportunity and limitations of existing products such as statins, the commercial potential for this product looks promising.Commercial discussions are progressing with potential partners best positioned to fully exploit the opportunity as a cholesterol and/or hypertension supplement, in isolation, or in combination with existing approaches."
OptiBiotix Health plc
www.optibiotix.com
Stephen O'Hara, Chief Executive
Contact via Walbrook below


Cairn Financial Advisers LLP
Tel: 020 7148 7900
Liam Murray / Avi Robinson



Hybridan LLP (Joint Broker)
Claire Louise Noyce
Tel: 020 3713 4581
Peterhouse Corporate Finance Ltd (Joint Broker)
Tel: 020 7469 0936
Lucy Williams / Duncan Vasey



Walbrook PR Ltd
Tel: 020 7933 8780 or optibiotix@walbrookpr.com
Anna Dunphy
Mob: 07876 741 001
Mike Wort
Mob: 07900 608 002
About OptiBiotix Health PLC - www.optibiotix.com 
OptiBiotix was formed in March 2012 to develop compounds which modify the human microbiome - the collective genome of the microbes in the body - to prevent and manage human disease. 
The aim of OptiBiotix is to discover and develop microbial strains, compounds and formulations, which modulate the human microbiome and can be used as food ingredients and supplements or active compounds for the prevention and management of human metabolic diseases, examples of which include obesity, cholesterol and lipid distribution and diabetes. 
OptiBiotix has established a pipeline of microbiome modulators that can impact on lipid and cholesterol management, energy harvest and appetite suppression. The development pipeline is fuelled by its proprietary OptiScreen and OptiBiotic platform technologies designed to identify metabolic pathways and compounds that impact on human physiology and bring potential health benefits. These platforms are applicable across a wider range of other human diseases. 

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