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REG-Oxford Instruments: Holding(s) in Company <Origin Href="QuoteRef">OXIG.L</Origin>

TR-1: Notifications of Major Interests in Shares                                                                                                                                                                                                                                                                                                                                                        
 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:                                                                                                                              Oxford Instruments PLC                                                                                                                                          
 2. Reason for notification (yes/no)                                                                                                                                                                                                                                                                                                                                                                     
 An acquisition or disposal of voting rights                                                                                                                                                                                                                                                                                                 Yes                                                         
 An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached                                                                                                                                                                                        No                                                          
 An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments                                                                                                                                                                                                                                  No                                                          
 An event changing the breakdown of voting rights                                                                                                                                                                                                                                                                                            No                                                          
 Other (please specify): Voluntary baseline disclosure in line with the UK implementation of the Amended Transparency Directive                                                                                                                                                                                                              No                                                          
 3. Full name of person(s) subject to notification obligation:                                                                                           Ameriprise Financial, Inc. and its group                                                                                                                                                                                                        
 4. Full name of shareholder(s) (if different from 3):                                                                                                   HSBC Global Custody Nominee (UK) Limited Nortrust Nominees LTD Securities Services Nominees Limited State Street Bank & Trust Boston State Street Nominees Limited Vidacos Nominees Ltd                                                         
 5. Date of transaction and date on which the threshold is crossed or reached:                                                                           26 January 2017                                                                                                                                                                                                                                 
 6. Date on which issuer notified:                                                                                                                       27 January 2017                                                                                                                                                                                                                                 
 7. Threshold(s) that is/are crossed or reached:                                                                                                         Above the threshold of 11%                                                                                                                                                                                                                      
 8: Notified Details                                                                                                                                                                                                                                                                                                                                                                                     
 A: Voting rights attached to shares                                                                                                                                                                                                                                                                                                                                                                     
 Class/type of shares If possible use ISIN code          Situation previous to the triggering transaction              Resulting situation after the triggering transaction                                                                                                                                                                                                                              
                                                                     Number of shares                    Number of voting rights     Number of shares                                            Number of voting rights                                                                                                 Perce 
                                                                                                                                                                                                                                                                                                                         ntage 
                                                                                                                                                                                                                                                                                                                         of   
                                                                                                                                                                                                                                                                                                                         votin 
                                                                                                                                                                                                                                                                                                                         g    
                                                                                                                                                                                                                                                                                                                         right 
                                                                                                                                                                                                                                                                                                                         s    
                                                                     Direct                                                                                                  Direct                                                                          Indirect                                Direct                                                      Indirect                                
 GB0006650450                                            5,785,267                           5,785,267                 31,506                                                31,506                                                                          6,477,061                               0.055%                                                      11.303%                                 
 B: Qualifying Financial Instruments                                                                                                                                                                                                                                                                                                                                                                     
 Resulting situation after the triggering transaction                                                                                                                                                                                                                                                                                                                                                    
 Type of financial instrument                                        Expiration date                     Exercise/ conversion period                                                             No. of voting rights that may be acquired if the instrument is exercised/converted.                                     Percentage of voting rights                                                     
                                                                                                                                                                                                                                                                                                                                                                                                         
 C: Financial Instruments with similar economic effect to Qualifying Financial Instruments                                                                                                                                                                                                                                                                                                               
 Resulting situation after the triggering transaction                                                                                                                                                                                                                                                                                                                                                    
 Type of financial instrument  Exercise Price                                    Expiration date                       Exercise / conversion period                                                                  No. of voting rights instrument refers to                   Percentage of voting rights                                                                                             
                                                                                                                                                                                                                                                                                 Nominal                                                                                             Delta               
                                                                                                                                                                                                                                                                                                                                                                                                         
 Total (A+B+C)                                                                                                                                                                                                                                                                                                                                                                                           
 Number of voting rights                                                                                                             Percentage of voting rights                                                                                                                                                                                                                                         
 6,508,567                                                                                                                           11.358%                                                                                                                                                                                                                                                             
 9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:                                                                                                                                                                                                                                                              
 Threadneedle Asset Management Limited (11.358%)  Threadneedle Asset Management Limited is wholly owned by TC Financing Limited, which is itself wholly owned by Threadneedle Asset Management Holdings Limited, which is itself wholly owned by TAM UK Holdings Limited, which is itself wholly owned by Threadneedle Holdings Limited, which is itself wholly owned by Threadneedle Asset Management Holdings SARL, which is itself wholly owned by Ameriprise International Holdings GmbH, which is itself wholly owned by 
 Ameriprise Financial, Inc.                                                                                                                                                                                                                                                                                                                                                                              
 Proxy Voting:                                                                                                                                                                                                                                                                                                                                                                                           
 10. Name of proxy holder:                                                                                                           N/A                                                                                                                                                                                                                                                                 
 11. Number of voting rights proxy holder will cease to hold:                                                                        N/A                                                                                                                                                                                                                                                                 
 12. Date on which proxy holder will cease to hold voting rights:                                                                    N/A                                                                                                                                                                                                                                                                 
 13. Additional information:                                                                                                         The Shares referred to in section 9 of this form are held in portfolios and funds managed on a discretionary basis by the entities set out in section 9. Please note that the Shares are held through certain nominee companies.                                    
 14 Contact name:                                                                                                                    Susan Johnson-Brett Company Secretary                                                                                                                                                                                                                               
 15. Contact telephone name:                                                                                                         01865 393 200                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                         



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