Israel's Pluristem sees positive results from leg pain study

Pluri

12/06/2018 11:38

TEL AVIV, June 12 (Reuters) - Israel's Pluristem
Therapeutics Inc  PSTI.O , a developer of placenta-based stem
cell products, said on Tuesday it had positive results from a
mid-stage study of its therapy to treat leg pain known as
intermittent claudication (IC).
    Pluristem said its PLX-PAD treatment reduced incidence of
revascularization and improved patients’ mobility. 
    IC - muscle pain and weakness brought on by exercise - is
usually associated with early-stage peripheral artery disease
and if not treated can progress to critical limb ischemia (CLI),
where patients are at risk of leg amputation and death.
    The Phase II study was designed to evaluate the safety,
efficacy and optimal dosing regimen for PLX-PAD cells in
patients with IC. Enrollment took place at 28 clinical sites in
the United States, Germany, South Korea and Israel.
    The study's results also validate the design of Pluralism's
advanced Phase III trial for CLI, the company said.

 (Reporting by Tova Cohen, Editing by Ari Rabinovitch)
 ((tova.cohen@thomsonreuters.com; +972-9-899-0222; Reuters
Messaging: tova.cohen.thomsonreuters.com@reuters.net))