** Shares of Israel-based drug developer PainReform Ltd
PRFX.O fall ~14% to $0.41 after the bell
** Says its supplier of active pharmaceutical ingredient
(API) has received a deficiency notice from the U.S. FDA,
related to a file representing the manufacturing process and
production facility for the API
** PRFX says second part of late-stage trial for lead drug
PRF-110 is expected to begin once the deficiency notice has been
resolved, adding that none of the issues raised relate to
PRF-110
** PRF-110 is being tested to provide postoperative pain
relief in patients undergoing surgery to treat a type of joint
deformity
** As of last close, PRFX shares up ~16% this year
(Reporting by Raghav Mahobe)
((Raghav.Mahobe@thomsonreuters.com;))