RCS - Redx Pharma plc - Redx to Present at the ERS International Congress

Redx PharmaAnnouncement

31/08/2022 07:00

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RNS Number : 6140X  Redx Pharma plc  31 August 2022

REDX PHARMA PLC

("Redx" or "the Company")

 

Redx to Present Preclinical Data Poster for RXC007 at the European Respiratory
Society International Congress

 

Alderley Park, 31 August 2022 Redx (AIM: REDX), the clinical-stage
biotechnology company focused on discovering and developing novel, small
molecule, highly targeted therapeutics for the treatment of cancer and
fibrotic disease, today announces that it will present a poster on RXC007 at
the forthcoming European Respiratory Society (ERS) International Congress (4-6
September 2022, Barcelona, Spain/virtual).

 

The poster will present preclinical data on the potential benefits of RXC007,
Redx's lead fibrosis asset, based on ex vivo and in vivo models of pulmonary
fibrosis. RXC007 is an orally available, highly selective small molecule
inhibitor that targets Rho Associated Coiled-Coil Containing Protein Kinase 2
(ROCK2) which sits at a nodal point in cell signalling pathways associated
with fibrosis. RXC007 is expected to enter Phase 2a clinical studies in
idiopathic pulmonary fibrosis (IPF) in 2022, following encouraging Phase 1
safety and pharmacokinetic data.

 

 Title:                       Effects of RXC007, a highly potent and selective ROCK2 inhibitor, in ex-vivo
                              and in vivo models of pulmonary fibrosis

 Abstract:                    PA453

 Day/Date:                    Sunday, 4 September 2022

 Session name and category:   TP-24 - Interstitial lung diseases diagnosis in the COVID-19 era: new tools
                              for new challenges

 

A copy of the poster will be made available on the Company's website following
the presentation at: https://www.redxpharma.com/scientific-publications/
(https://www.redxpharma.com/scientific-publications/)

 

 For further information, please contact:

 Redx Pharma Plc

 UK Headquarters                                             T: +44 (0)1625 469 918

 Caitlin Pearson, Head of Communications ir@redxpharma.com
 (mailto:ir@redxpharma.com)

 Lisa Anson, Chief Executive Officer

 US Office

 Peter Collum, Chief Financial Officer

 SPARK Advisory Partners (Nominated Adviser)                 T: +44 (0)203 368 3550
 Matt Davis/ Adam Dawes

 WG Partners LLP (Joint Broker)                              T: +44 (0)203 705 9330
 Claes Spång/ Satheesh Nadarajah/ David Wilson

 Panmure Gordon (UK) Limited (Joint Broker)                  T: +44 (0)207 886 2500
 Rupert Dearden/ Freddy Crossley/ Emma Earl

 FTI Consulting                                              T: +44 (0)203 727 1000
 Simon Conway/ Ciara Martin

 

About Redx Pharma Plc

Redx Pharma (AIM: REDX) is a clinical-stage biotechnology company focused on
the discovery and development of novel, small molecule, highly targeted
therapeutics for the treatment of cancer and fibrotic diseases, aiming
initially to progress them to clinical proof of concept before evaluating
options for further development and potential value creation. Redx's lead
oncology product candidate, the Porcupine inhibitor RXC004, commenced a Phase
2 programme in November 2021. The Company's selective ROCK2 inhibitor product
candidate, RXC007, is in development for idiopathic pulmonary fibrosis and
commenced a Phase 1 clinical trial in June 2021. Encouraging safety and
pharmacokinetic data has been reported, and a Phase 2 clinical program is
confirmed to start in 2022. Redx's third drug candidate, RXC008, a GI-targeted
ROCK inhibitor for the treatment of fibrostenotic Crohn's disease, is
currently in pre-IND stage, with Phase 1 clinical studies expected to commence
in 2023.

 

The Company has a strong track record of discovering new drug candidates
through its core strengths in medicinal chemistry and translational science,
enabling the Company to discover and develop differentiated therapeutics
against biologically or clinically validated targets. The Company's
accomplishments are evidenced not only by its two wholly-owned clinical-stage
product candidates and rapidly expanding pipeline, but also by its strategic
transactions, including the sale of pirtobrutinib (RXC005, LOXO-305), a BTK
inhibitor now in Phase 3 clinical development by Eli Lilly following its
acquisition of Loxo Oncology and RXC006, a Porcupine inhibitor targeting
fibrotic diseases including idiopathic pulmonary fibrosis (IPF), which
AstraZeneca is progressing in a Phase 1 clinical study. In addition, Redx has
forged collaborations with Jazz Pharmaceuticals, which includes JZP815, a
preclinical pan-RAF inhibitor, which has received IND clearance from the US
FDA, and an early stage oncology research collaboration.

 

To subscribe to Email Alerts from Redx, please visit:
www.redxpharma.com/investor-centre/email-alerts/
(http://www.redxpharma.com/investor-centre/email-alerts/)

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