(Updates)
** Shares of Regulus Therapeutics RGLS.O more than double
to a near two-year high of $2.84
** Stock set for biggest one-day pct rise in nearly 10
years, if gains hold
** Co says its therapy for autosomal dominant polycystic
kidney disease (ADPKD) in an early-stage trial showed a response
in patients based on levels of polycystins in urine; polycystins
are a group of proteins that promote formation of cysts
** RGLS says three patients with the highest increases in
polycystins also had reductions in total kidney cyst volume
** ADPKD is the most common form of polycystic kidney
disease, which causes numerous cysts to grow in the kidneys, and
may lead to kidney failure
** Stock up 127.2% in the last 12 months
(Reporting by Puyaan Singh)
((Puyaan.Singh@thomsonreuters.com;))