** Shares of antidepressant drug developer Relmada
Therapeutics Inc RLMD.O fall 4.4% to $6.2 premarket - on track
for their second straight session of losses
** Jefferies downgrades to 'hold' from 'buy', citing
decreased confidence in co's depression pill, REL-1017, after it
fails to meet main goal in keenly anticipated late-stage trial
** Brokerage also cuts PT to $8 from $75 on low clarity in
co's ability to show significant improvement in depression
symptoms compared to placebo in upcoming late-stage trials
** Also views co as a 'show-me' story, eyeing on more
late-stage data from its other 2 depression treatment trials in
2023
** Jefferies says current class of drug do not achieve the
rapid-acting antidepressant effect of REL-1017 and awaits more
clarity from co's discussions with FDA in the coming weeks
** Up to Thursday's close, stock was down 71.3% YTD
(Reporting by Pratik Jain)
((Pratik.Jain@thomsonreuters.com;))