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REG - Roquefort Theraptcs. - Interim Results to 30 June 2022

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RNS Number : 3722A  Roquefort Therapeutics PLC  23 September 2022

23 September 2022

 

Roquefort Therapeutics plc

("Roquefort Therapeutics" or the "Company")

 

Interim Results to 30 June 2022

 

Roquefort Therapeutics (LSE:ROQ, OTCQB:ROQAF), the Main Market listed biotech
company focused on developing first in class drugs in the high value and high
growth oncology segment, is pleased to present its interim results for the
six-month period ended 30 June 2022 (the "period" or "H1").

 

Highlights

·      Collaborative work with Murdoch University, Western
Australia to design and test a novel series of gene silencing reagents,
antisense oligonucleotides, targeting Midkine

·      Positive pre-clinical trials results demonstrated that the
Company's lead oligonucleotide drug candidates significantly reduce Midkine
levels seen in human cancer cells

·      Portfolio review including the Midkine antibody programs to
assess commercial potential

·      Midkine patent filed following positive pe-clinical in vitro
trials

·      Significantly strengthened the Board with two highly experienced
sector NED appointments, Jean Duvall and Simon Sinclair

·      Professor Trevor Jones appointment as advisor to the Board

·      Announced on 22 June 2022 a conditional share sale and purchase
agreement with the shareholders of Oncogeni Limited ("Oncogeni"),
a UK biotech company developing novel patented cancer medicines and a
placing to raise £1 million at a price of 14p per share

·      Cash at period end of £3,328,573 and for the 6 months to 30 June
2022, net loss of £762,281

 

Post Period End Highlights

·      Completion of Oncogeni acquisition for £5.5 million, a
successful £1 million fundraise and key board appointments:

o  Ajan Reginald as CEO and Professor Sir Martin Evans as Group Chief
Scientific Officer, Darrin Disley as NED

·      Company has pivoted towards a material oncology business with
four fully funded, novel, patent-protected pre-clinical anti-cancer medicines

·      Near-term clinical trial application and licensing opportunities
from advanced stage of development of Midkine and siRNA products

·      State of the art facility located in Stratford-upon-Avon which
has the infrastructure required for the pre-clinical development of the
Group's portfolio of antibodies, oligonucleotides and cell and gene therapies

·      On 15 July 2022, the Company announced that trading in the
Company's Ordinary Shares had commenced on the OTCQB Venture Market in the
United States with the ticker: ROQAF

Outlook

·      Potential to drive significant value from our novel oncology
programs

·      Management is targeting clinical readiness for one of its
development programs during H2 2023

Chairman Statement

I am pleased to present the interim financial statements to shareholders for
the six months ending 30 June 2022.

 

The Company made encouraging progress with its pre-clinical program and on 17
January 2022 completed the first stage screening of a novel series of gene
silencing reagents targeting Midkine, with the most promising lead drugs
selected. The lead compounds were synthesised in preparation for in vitro
experiments to test efficacy in altering cancer cell properties. This is a
first-in-class drug target with significant clinical potential and we believe
the targeted delivery of Midkine inhibiting RNA therapeutic drugs to tumours
represents a novel anti-cancer treatment strategy.

Following the positive pre-clinical trials, the Company announced on 21 March
2022 that it had filed its first composition of matter provisional patent
application for a new class of RNA therapeutic drugs targeting Midkine. The in
vitro experiments generated very positive results demonstrating that the
Company's lead oligonucleotide drug candidates significantly reduce Midkine
levels seen in human cancer cells.

In order to drive the Company further towards commercialisation, Roquefort
Therapeutics strengthened the team with three appointments from the
pharmaceutical industry, each of whom add significant relevant expertise in
drug development, commercialising programs and driving pre-clinical and
clinical programs. As such, I'd like to again welcome Professor Trevor Jones,
as strategic and scientific advisor to the Board who joined the Company on 14
February 2022, and Ms Jean Duvall and Dr Simon Sinclair as Non-Executive
Directors, who joined on 5 April and 20 April 2022, respectively. All three
appointments will help further the Company's ability to capitalise on the
significant growth potential that Midkine inhibiting drugs offer.

The collaboration with Murdoch University continued to yield encouraging
results with the Company's lead oligonucleotide drug candidates. In addition,
following a review of the wider portfolio acquired with Lyramid, it resulted
in the conclusion that two of the antibody programs have high commercial
potential and we will therefore be accelerating development of those as we aim
to be the first to market with an anti-Midkine oncology antibody. These
developments broaden the commercial potential within the Company and enhance
the upside value that we believe can be delivered as we progress the programs.

 

On 22 June 2022, Roquefort Therapeutics announced that it had entered into a
conditional share sale and purchase agreement with Oncogeni Ltd, a UK biotech
company developing novel patented cancer medicines, pursuant to which
Roquefort Therapeutics had agreed to acquire the entire issued share capital
of Oncogeni for an aggregate consideration to be satisfied by the issue of
50,000,000 new ordinary shares in the Company.  I am pleased to say that
following the publication of a prospectus, the acquisition completed on 16
September 2022.

 

Post Period End

On 16 September 2022, we completed the fundraise and the acquisition of
Oncogeni, which pivots Roquefort Therapeutics into a material oncology biotech
company with a pre-clinical anti-cancer portfolio that is patent protected and
fully funded to clinical trial submission.

 

The Roquefort Therapeutics portfolio consists of four fully funded, novel,
patent-protected pre-clinical anti-cancer medicines.  The highly
complementary profile of four best-in-class medicines consists of:

•     Midkine antibodies with significant in vivo efficacy and
toxicology studies;

•     Midkine RNA therapeutics with novel anti-cancer gene editing
action;

•     Mesodermal Killer (MK) cells, are a new class of cellular medicine
engineered to kill cancer both directly and by enhancing the activity of
Natural Killer cells; and

•     Novel siRNAs (small interfering RNA) inhibit STAT-6, to kill solid
tumours.

 

The Company now has the potential to meet significant value inflection with
the average valuation of biotech companies with a single lead asset completing
pre-clinical development being circa US$71 million (£55 million,
2005-2020) 1  (#_ftn1) . In that context, now that Roquefort Therapeutics has
four lead assets, we believe the Company and its IP represents a highly
compelling value proposition.

 

In addition to the expanded portfolio, Roquefort Therapeutics now has a
state-of-the-art laboratory and manufacturing facility which provides the
Group with major cost saving and time advantages as we progress through the
pre-clinical stage of development. In addition, the acquisition strengthens
our Board and senior management team with complementary skills and expertise,
and I am very excited with the team we have in place to drive our programs
forward and to realise value.

 

We further strengthened the Roquefort Therapeutics senior team by welcoming
Ajan Reginald as CEO, Professor Sir Martin Evans as Group Chief Scientific
Officer and Dr Darrin Disley as NED to the Board of Roquefort Therapeutics,
and Professor Armand Keating as Roquefort Therapeutics' new independent Chief
Medical Advisor. Sir Martin Evans, a Nobel Prize winning scientist for his
work in embryonic stem cells and DNA research will be incredibly valuable as
Group Chief Scientific Officer throughout our preclinical studies. Ajan
Reginald's experience in commercialisation both within big pharma and in
biotech will be invaluable as we look to achieve value in this high growth
segment of life sciences.  Dr Darrin Disley is a great addition as
Non-Executive Director, and his expertise in fundraising and value creation is
incredibly complementary to our existing Board of Directors. Professor Keating
is a renowned expert in anti-cancer cell therapy, a key area of Roquefort
Therapeutics' research and is a welcome addition as Chief Medical Advisor.
The quality and industry standing of the team assembled reflects the
opportunity of the science being progressed by Roquefort Therapeutics.

 

Outlook

Roquefort Therapeutics has achieved a great deal in the reporting period, as
demonstrated by the significant progress made with our oligonucleotide Midkine
programs and following a review of the wider Lyramid portfolio we concluded
that two of the antibody programs have high commercial potential and we will
therefore be accelerating development in that area.  Following the
acquisition of Oncogeni, we are a material oncology focused biotech business.
It is very rare for a company of our size and valuation to have four
substantial anti-cancer pre-clinical assets, and we have the potential to
drive significant value from our novel oncology programs. We aim to have one
program clinic ready during H2 2023, as we are now better placed with Oncogeni
to complete the value milestone of IND / CTA filings. The team we have in
place now is truly world class, with a proven track record in drug development
which will help drive innovation and ultimately value in our portfolio of
oncology drugs, and I am confident in the prospects of Roquefort
Therapeutics.  I look forward to providing shareholders with progress of our
programs over the next few months.   Finally I would like to thank
shareholders for their continued support of Roquefort Therapeutics and to
welcome new shareholders.

 

Financial Review

For the 6 months to 30 June 2022, the Group reported a net loss of £762,281,
mostly relating to administrative expenses. The Group maintained a strong
balance sheet position at 30 June 2022, most notably holding cash at period
end of £3,328,573.

 

Directors

The following directors have held office during the period to 30 June 2022:

 

Mr Stephen West, Executive Chairman

Dr Michael Stein, Non-Executive Director

Mr Simon Sinclair, Non-Executive Director (appointed 20 April 2022)

Ms Jean Duvall, Non-Executive Director (appointed 5 April 2022)

Mr Mark Freeman, Non-Executive Director (resigned 16 September 2022)

Mr Mark Rollins, Non-Executive Director (resigned 4 April
2022)

 

Corporate Governance

The UK Corporate Governance Code (September 2014) ("the Code"), as appended to
the Listing Rules, sets out the Principles of Good Corporate Governance and
Code Provisions which are applicable to listed companies incorporated in the
United Kingdom. As a standard listed company, the Company is not subject to
the Code; however, the Board acknowledges the importance of high standards of
corporate governance and endeavours, given the Company's size and the
constitution of the Board, to comply with the principles set out in the QCA
Corporate Governance Code. The QCA Code sets out a standard of minimum best
practice for small and mid-size quoted companies.

 

Responsibility Statement

The Directors are responsible for preparing the Unaudited Interim Condensed
Financial Statements in accordance with the Disclosure and Transparency Rules
of the United Kingdom's Financial Conduct Authority ("DTR") and with
International Accounting Standard 34 on Interim Reporting ("IAS 34"). The
directors confirm that, to the best of their knowledge, this condensed interim
report has been prepared in accordance with IAS 34 as adopted by the European
Union. The interim management report includes a fair review of the information
required by DTR 4.2.7 and DTR 4.2.8, namely:

•      an indication of important events that have occurred during the
six months ended 30 June 2022 and their impact on the condensed financial
statements for the period, and a description of the principal risks and
uncertainties for the remaining six months of the financial year; and

•      related party transactions that have taken place in the six
months ended 30 June 2022 and that have materially affected the financial
position of the performance of the business during that period.

 

 

ENDS

Enquiries:
 Roquefort Therapeutics plc
 Stephen West (Chairman) / Ajan Reginald (CEO)  +44 (0)20 3290 9339

 Hybridan LLP (Joint Broker)

 Claire Louise Noyce                            +44 (0)203 764 2341

 Optiva Securities Limited (Joint Broker)
 Christian Dennis                               +44 (0)20 3411 1881

 Buchanan (Public Relations)

 Ben Romney / Jamie Hooper / George Beale       +44 (0)20 7466 5000

 

LEI: ‎254900P4SISIWOR9RH34

 

ROQUEFORT THERAPEUTICS PLC - CONDENSED INTERIM FINANCIAL STATEMENTS

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

AS AT 30 JUNE 2022

 

 

 

                                                                                 Unaudited                          Unaudited                          Audited
                                                                                 6 Month Period ended 30 June 2022  6 Month Period ended 30 June 2021  Period ended 31 December 2021
                                                                                 £                                  £                                  £
                                                                          Notes
                                                                                 -                                  -                                  719

 Revenue
                                                                                 -                                  -                                  130

 Other income
                                                                                 -                                  -                                  (10,069)

 Cost of goods
                                                                          7      (543,041)                          (301,232)                          (907,515)

 Administrative expenses
                                                                                 (69,288)                           -                                  (698)

 Research and Development
                                                                          10     (149,952)                          -                                  -

 Amortisation of Intangible assets
                                                                                 (762,281)                          (301,232)                          (917,433)

 Operating loss
                                                                                 -                                  -                                  -

 Finance income/(expense)
                                                                                 (762,281)                          (301,232)                          (917,433)

 Loss before taxation
                                                                          8      -                                  -                                  -

 Income tax
                                                                                 (762,281)                          (301,232)                          (917,433)

 Loss for the period from continuing operations
 Total loss for the period attributable to equity holders of the Company         (762,281)                          (301,232)                          (917,433)
                                                                                 -                                  -                                  -

 Other comprehensive loss
 Total comprehensive loss attributable to equity holders of the Company          (762,281)                          (301,232)                          (917,433)

 Basic and diluted earnings per ordinary share (pence)                    9      (2.05)                             (1.79)                             (3.71)

 

 

The notes form an integral part of the Unaudited Condensed Interim Financial
Statements.

ROQUEFORT THERAPEUTICS PLC - CONDENSED INTERIM FINANCIAL STATEMENTS

CONSOLIDATED STATEMENT OF FINANICAL POSITION

AS AT 30 JUNE 2022

 

 

                                      Unaudited                  Unaudited   Audited
                                      Period ended 30 June 2022  Period      Period ended 31 December 2021

ended 30

June 2021
                                      £                          £           £

 ASSETS                        Notes
 NON-CURRENT ASSETS
 Intangible assets             10     1,331,578                  -           1,481,530
 CURRENT ASSETS
 Cash and cash equivalents            3,328,573                  880,445     899,721
 Trade and other receivables   11     98,520                     13,241      2,178,783
 TOTAL ASSETS                         4,758,671                  893,686     4,560,034

 LIABILITIES
 NON-CURRENT LIABILITIES
 Deferred tax liabilities             281,911                    -           281,911
 CURRENT LIABILITIES
 Trade and other payables      12     1,094,389                  14,331      195,517
 TOTAL LIABILITIES                    1,376,300                  14,331      477,428

 NET ASSETS                           3,382,371                  879,355     4,082,606
 EQUITY
 Share Capital                 13     719,000                    339,000     719,000
 Share Premium                 13     3,910,595                  774,300     3,910,595
 Share Based Payment Reserves  14     424,219                    74,911      366,708
 Retained Earnings                    (1,676,602)                (308,856)   (914,321)
 Translation reserve                  5,159                      -           624
 TOTAL EQUITY                         3,382,371                  879,355     4,082,606

 

The notes form an integral part of the Unaudited Condensed Interim Financial
Statements.

ROQUEFORT THERAPEUTICS PLC - CONDENSED INTERIM FINANCIAL STATEMENTS

CONSOLIDATED STATEMENT OF CASH FLOW

AS AT 30 JUNE 2022

 

 

                                                           Unaudited                          Unaudited                          Audited
                                                           6 Month Period ended 30 June 2022  6 Month Period ended 30 June 2021  Period ended 31 December 2021
                                                           £                                  £                                  £
 Cash flow from operating activities
 Loss before income tax                                    (762,281)                          (301,232)                          (996,068)

 Adjustments for:
 Share based payment                                       57,511                             74,911                             366,708
 Foreign exchange                                          (5,160)                            -                                  765
 Non-cash adjustment                                       -                                  -                                  (2,602)
 Amortisation of intangible asset                          149,952                            -                                  -

 Changes in working capital:
 Decrease / (increase) in receivables                      2,083,286                          (11,798)                           (2,130,636)
 Increase / (decrease) in payables                         (121,325)                          14,331                             129,525
 Decrease in Inventory                                     -                                  -                                  9,273

 Net cash used in operating activities                     1,401,983                          (223,788)                          (2,623,035)

 Cash flow from investing activities
 Acquisition of subsidiary, net of cash acquired           -                                  -                                  (1,106,225)

 Net cash used in investing activities                     -                                  -                                  (1,106,225)

 Cashflows from financing activities
 Proceeds from issue of ordinary shares                    -                                  1,015,000                          4,789,000
 Share issue costs                                         -                                  (25,700)                           (159,405)
 Proceeds from fundraise                                   1,015,000                          -                                  -

 Net cash used in financing activities                     1,015,000                          989,300                            4,629,595

 Net increase in cash and cash equivalents
 Net increase in cash held                                 2,416,983                          765,511                            900,335
 Cash and cash equivalents at beginning of the period      899,721                            114,933                            -
 Foreign exchange impact on cash                           11,869                             -                                  (614)

 Cash and cash equivalents at end of the period            3,328,573                          880,445                            899,721

 

The notes form an integral part of the Unaudited Condensed Interim Financial
Statements.

ROQUEFORT THERAPEUTICS PLC - CONDENSED INTERIM FINANCIAL STATEMENTS

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

AS AT 30 JUNE 2022

 

 

 

                        Ordinary Share capital  Share Premium  Share Based Payment Reserves                      Translation Reserve

                                                                                             Retained earnings                        Total equity
                        £                       £              £                             £                   £                    £
                        719,000                 3,910,595      366,708                       (914,321)                                4,082,606

 As at 1 January 2022                                                                                            624
                                                               57,511                        (762,281)           4,535                (700,235)

 Loss for the period    -                       -
                        719,000                 3,910,595      424,219                       (1,676,602)         5,159                3,382,371

 As at 30 June 2022

 

 

 

                                           Ordinary Share capital  Share Premium  Share Based Payment Reserves                      Translation Reserve

                                                                                                                Retained earnings                        Total equity
                                           £                       £              £                             £                   £                    £
                                           -                       -              -                             -                   -                    -

 At incorporation
                                           -                       -              -                             3,112               -                    3,112

 On acquisition of subsidiary
                                           -                       -              -                             (917,433)           624                  (916,809)

 Loss for the Period
                                           -                       -              -                             (914,321)           624                  (913,697)

 Total comprehensive loss for the period

 Transactions with owners
                                           719,000                 4,070,000      -                             -                   -                    4,789,000

 Ordinary shares issued
                                           -                       -              366,708                       -                   -                    366,708

 Warrants issued
                                           -                       (159,405)      -                             -                   -                    (159,405)

 Share issue costs
                                           719,000                 3,910,595      366,708                       -                   -                    4,996,303

 Total transactions with owners
                                           719,000                 3,910,595      366,708                       (914,321)           624                  4,082,606

 As at 31 December 2021

 

 

 

                                           Ordinary Share capital  Share Premium  Share Based Payment Reserves

                                                                                                                Retained earnings   Total equity
                                           £                       £              £                             £                   £
                                           124,000                 -              -                             (7,624)             116,376

 At 1 January 2021
                                           -                       -              -                             (301,232)           (301,232)

 Loss for the Period
                                           -                       -              -                             (301,232)           (301,232)

 Total comprehensive loss for the period

 Transactions with owners
                                           200,000                 800,000        -                             -                   1,000,000

 Ordinary shares issued
                                           -                       -              74,911                        -                   74,911

 Warrants issued
                                           15,000                  -              -                             -                   15,000

 Warrants exercised
                                           -                       (25,700)       -                             -                   (25,700)

 Share issue costs
                                           215,000                 774,300        74,911                        -                   1,064,211

 Total transactions with owners
                                           339,000                 774,300        74,911                        (308,856)           879,355

 As at 30 June 2021

 

 

The notes form an integral part of the Unaudited Condensed Interim Financial
Statements.

ROQUEFORT THERAPEUTICS PLC - CONDENSED INTERIM FINANCIAL STATEMENTS

NOTES TO THE INTERIM FINANCIAL INFORMATION

FOR THE 6 MONTHS ENDED 30 JUNE 2022

 

1              General Information

The Company was incorporated on 17 August 2020 as a public company in England
and Wales with company number 12819145 under the Companies Act.

The address of its registered office is Eccleston Yards, 25 Eccleston Place,
London SW1W 9NF, United Kingdom.

The principal activity of the Company during the period ended 30 June 2022 was
the development of Midkine inhibitors through pre-clinical trials and, upon
success, through clinical development and commercialisation.  Midkine is a
novel therapeutic target that provides a platform for drug development to
treat numerous diseases including severe inflammatory diseases, autoimmune
disorders and cancer.

The Company listed on the London Stock Exchange ("LSE") on 22 March 2021.

The condensed consolidated interim financial statements of the Group have been
prepared in accordance with UK adopted International Accounting Standards as
issued by the UK Accounting Standards Board (ASB). They have been prepared
under the assumption that the Group operates on a going concern basis.

2              New Standards and Interpretations

There were no new standards or interpretations adopted by the Company in the
period.

Standards, amendments and interpretations that are not yet effective and have
not been early adopted are as follows:

 

 Standard             Impact on initial application                             Effective date
 IFRS 3               Reference to Conceptual Framework                         1 January 2022
 IAS 37               Onerous contracts                                         1 January 2022
 IAS 16               Proceeds before intended use                              1 January 2022
 Annual improvements  2018-2020 Cycle                                           1 January 2022
 IFRS 17              Insurance contracts                                       1 January 2023
 IAS 8                Accounting estimates                                      1 January 2023
 IAS 1                Classification of Liabilities as Current or Non-Current.  1 January 2023

The Directors are evaluating the impact of the new and amended standards
above. The Directors believe that these new and amended standards are not
expected to have a material impact on the financial statements of the Group.

3              Summary of Significant Accounting Policies

Basis of Preparation

These condensed consolidated interim financial statements do not comprise
statutory accounts within the meaning of section 434 of the Companies Act
2006. Statutory accounts for the year ended 31 December 2021 were approved by
the Board of Directors on 10 May 2022 and delivered to the Registrar of
Companies. The report of the auditors on those accounts was unqualified, did
not contain an emphasis of matter paragraph and did not contain any statement
under section 498 of the Companies Act 2006.

These condensed consolidated interim financial statements have been prepared
in accordance with the Disclosure Guidance and Transparency Rules of the
Financial Conduct Authority and with  IAS 34 "Interim Financial Statements."
The condensed consolidated interim financial statements do not include all
disclosures that would otherwise be required in a complete set of financial
statements but have been prepared in accordance with the existing accounting
policies of the Company. The condensed consolidated interim financial
statements should be read in conjunction with the annual financial statements
for the year ended 31 December 2021, which have been prepared in accordance
with UK adopted International Accounting Standards and the Companies Act 2006.

The condensed consolidated interim financial statements for the period ended
30 June 2022 are unaudited.

The condensed consolidated interim financial statements are presented in £
unless otherwise stated, which is the Company's functional and presentational
currency.

Going concern

The preparation of the financial statements requires an assessment on the
validity of the going concern assumption.

The Directors, having made due and careful enquiry, are of the opinion that
the Company and the Group have adequate working capital to execute its
operations over the next 12 months. As a result, the Directors have adopted
the going concern basis of accounting in the preparation of the interim
financial statements.

Furthermore, the Directors acknowledge that COVID-19 has had, and will
continue to have, a significant adverse impact on the global economy. The
Directors do not believe that COVID-19's impact on the global economy gives
rise to a material uncertainty in respect of the Company's going concern
status due to the Company not being dependent on future financing being
obtained in the going concern period.

Accounting policies

The same accounting policies, presentation and methods of computation have
been followed in these condensed consolidated interim financial statements as
were applied in the preparation of the Company's and the Group's financial
statements for the period ended 31 December 2021.

Segment reporting

The Company considers it has one operating segment and therefore the results
are as presented in the primary statements.

Forward-looking statements

Certain statements in this condensed set of consolidated interim financial
statements are forward looking. Although the Group believes that the
expectations reflected in these forward-looking statements are reasonable, we
can give no assurance that these expectations will prove to be correct. As
these statements involve risks and uncertainties, actual results may differ
materially from those expressed or implied by these forward-looking
statements. We undertake no obligation to update any forward-looking
statements, whether as a result of new information, future events or
otherwise.

4              Critical accounting estimates and judgments

In preparing the condensed consolidated interim financial statements, the
Directors have to make judgments on how to apply the Company's accounting
policies and make estimates about the future. Estimates and judgements are
continuously evaluated based on historical experiences and other factors,
including expectations of future events that are believed to be reasonable
under the circumstances. In the future, actual experience may deviate from
these estimates and assumptions.

Actual results may differ from these estimates. In preparing these condensed
consolidated interim financial statements, the significant judgements made by
management in applying the Group's accounting policies and the key sources of
estimation uncertainty were the same as those that applied to the financial
statements for the year ended 31 December 2021.

5              Financial risk management

The Group's activities expose it to a variety of financial risks, including
market risk (which includes currency risk and interest rate risk), credit risk
and liquidity risk. The condensed consolidated interim financial statements do
not include all financial risk management information and disclosures required
in the annual financial statements; they should be read in conjunction with
the Group's annual financial statements as at 31 December 2021. There have
been no changes in any risk management policies since the year.

 

6              Directors' Remuneration

Total Directors' remuneration for the period was as follows:

                             Period ended  Period ended  Period ended

                             30 June       30 June       31 December

                              2022         2021          2021

                             £             £             £
 Fees to directors           80,286        16,613        47,301
 Bonus                       -             -             10,000
 Share based payment charge  38,341        6,833         178,053
                             118,627       23,446        235,354

 

 

7              Operating Loss

Operating loss from continued operations:

                                             Period ended  Period ended  Period ended

                                             30 June       30 June       31 December

                                              2022          2021          2021

                                             £             £             £
 Costs associated with the IPO               -             (182,053)     (182,053)
 Directors' and employee costs               (149,586)     (16,613)      (59,607)
 Share based payments                        (57,511)      (6,833)       (248,326)
 Costs on the acquisition of Lyramid         -             -             (224,744)
 Costs associated with Oncogeni acquisition  (10,000)      -             -
 Consulting and professional fees            (156,703)     (76,874)      (156,972)
 OTC Listing costs                           (19,168)      -             -
 Other expenditure                           (150,073)     (18,859)      (35,813)
                                             (543,041)     (301,232)     (907,515)

 

 

 

8              Income Tax
                     Period ended  Period ended  Period ended

                     30 June       30 June       31 December

                      2022          2021          2021

                     £             £             £
 Current tax         -             -             -
 Deferred tax        -             -             -
 Income Tax expense  -             -             -

 

Income tax can be reconciled to the loss in the statement of comprehensive
income as follows:

                                                                Period ended  Period ended  Period ended

                                                                30 June       30 June       31 December

                                                                 2022          2021          2021

                                                                £             £             £
 Loss before taxation                                           (762,281)     (301,232)     (917,433)
 Tax at the UK corporation tax rate of 19%                      144,833       57,234        174,312
 Effect of overseas tax rate                                    11,279        -             867
 Tax losses on which no deferred tax asset has been recognised  (156,112)     (57,234)      (175,179)
 Total tax (charge) / credit                                    -             -             -

 

 

9              Earnings per Ordinary Share
                                                Period ended  Period ended  Period ended

                                                30 June       30 June       31 December

                                                 2022          2021          2021

                                                £             £             £
 Loss attributable to equity shareholders       (762,281)     (301,232)     (917,433)
 Weighted number of ordinary shares in issue    37,209,663    16,832,177    24,701,793
 Basic and diluted loss per share in pence      (2.05)        (1.79)        (3.71)

 

10           Intangible assets
                                      Period ended  Period ended  Period ended

                                      30 June       30 June       31 December

                                       2022          2021          2021

                                      £             £             £

 Cost at beginning of period          1,481,530     -             -
 Acquired Goodwill in period          -             -             281,911
 Acquired Licences in period          -             -             1,199,619
 Cost at end of period                1,481,530     -             1,481,530

 Amortisation at beginning of period  -             -             -
 Charge in period                     (149,952)     -             -
 Amortisation at period end           (149,952)     -             -

 Carrying value at period end         1,331,578     -             1,481,530

 

 

11           Trade and other receivables
                                 Period ended  Period ended  Period ended

                                 30 June       30 June       31 December

                                  2022          2021          2021

                                 £             £             £
 Trade receivables               -             -             17,825
 Prepayments and accrued income  65,344        6,607         25,927
 Other receivables               33,176        6,634         2,135,031
                                 98,520        13,241        2,178,783

 

 

12           Trade and other payables
                               Period ended  Period ended  Period ended

                               30 June       30 June       31 December

                                2022          2021          2021

                               £             £             £
 Trade creditors               36,997        5,259         40,718
 Accruals and other creditors  42,392        9,072         154,799
 Sundry creditor               1,015,000     -             -
                               1,094,389     14,331        195,517

 

13           Share Capital
                                        Ordinary Shares  Share       Capital        Share Premium  Total
                                        #                £                          £              £
 At 1 January 2022 and at 30 June 2022  71,900,000       719,000                    3,910,595      4,629,595

 

 

14           Share Based Payment Reserves
                                       Total

                                       £
 At 1 January 2022                     366,708
 Director and Adviser warrants issued  57,511
 At 30 June 2022                       424,219

 

The fair value of the services received in return for the share options
granted are measured by reference to the fair value of the share options
granted. The estimate of the fair value of the share options granted is
measured based on the Black-Scholes valuations model. Measurement inputs and
assumptions are as follows:

 

Warrants

 Warrant             Number of warrants  Share Price  Exercise Price  Expected volatility  Expected life  Risk free rate  Expected dividends
 Director            750,000             £0.05        £0.05           50.00%               5              15.00%          0.00%
 Director            750,000             £0.05        £0.10           50.00%               5              15.00%          0.00%
 Broker              1,500,000           £0.05        £0.01           50.00%               0.08           15.00%          0.00%
 Broker Placing      480,000             £0.05        £0.05           50.00%               3              15.00%          0.00%
 Completion          3,000,000           £0.10        £0.10           50.00%               3              15.00%          0.00%
 Senior Mgt          4,500,000           £0.10        £0.15           50.00%               5              15.00%          0.00%
 Optiva              1,320,000           £0.10        £0.10           50.00%               3              15.00%          0.00%
 Orana               175,000             £0.10        £0.10           50.00%               3              15.00%          0.00%
 Director / Adviser  900,000             £0.15        £0.15           50.00%               5              15.00%          0.00%

 

 

 

 

                                 Number of Warrants  Exercise Price  Expiry date
 On incorporation                -                   -               -
 Issued on 25 November 2020 (1)  5,000,000           £0.10           22 March 2026
 Issued on 25 November 2020 (1)  7,000,000           £0.10           22 March 2026
 Issued on 17 March 2021         1,500,000           £0.01           20 April 2021
 Issued on 17 March 2021         480,000             £0.05           22 March 2024
 Issued on 17 March 2021 (1)     750,000             £0.05           22 March 2026
 Issued on 17 March 2021 (1)     750,000             £0.10           22 March 2026
 Issued on 17 March 2021         10,000,000          £0.10           21 March 2023
 Exercised on 19 April 2021      (1,500,000)         £0.01           20 April 2021
 Issued on 18 August 2021        1,500,000           £0.10           22 March 2023
 Issued on 13 October 2021       3,000,000           £0.10           21 December 2024
 Issued on 13 October 2021       4,500,000           £0.15           21 December 2026
 Issued on 13 October 2021       1,320,000           £0.10           21 December 2024
 Issued on 13 October 2021       175,000             £0.10           21 December 2024
 Issued on 22 June 2022(2)       900,000             £0.15           21 June 2027
 At 30 June 2022                 35,375,000          £0.106

 

The weighted average time to expiry of the warrants as at 30 June 2022 is 3.10
years.

(1) The warrants vested on 21 March 2022, being 12 months from date of
admission.

(2) The warrants have been issued to Jean Duvall (300,000) and Simon Sinclair
(300,000) following their appointment to the Board during the period and form
part of their annual remuneration package. A further 300,000 warrants were
issued to Trevor Jones in his capacity as an adviser to the Board.

The warrants pertaining to Simon Sinclair are held in the name of Livingstone
Investment Holdings Ltd, a company in which he has a beneficial interest.

The warrants have a term of 5 years and are exercisable at a price of 15
pence, with 50% exercisable after 12 months and the balance exercisable after
24 months.

 

15           Related Party Transactions

Orana Corporate LLP has a service agreement with the Group for the provision
of accounting and company secretarial services. In the period Orana Corporate
LLP received £24,000 for these services from the Group.

16           Post Balance Sheet Events

On 15 July 2022, the Company announced that trading in the Company's Ordinary
Shares had commenced on the OTCQB Venture Market in the United States with the
ticker: ROQAF.

 

On 16 September 2022, the Company announced the completion of its acquisition
of the entire issued share capital of Oncogeni Limited ("Oncogeni") for an
aggregate consideration of £5,500,000 satisfied by the issue of 50,000,000
new ordinary shares in the Company to the shareholders of Oncogeni, together
with a successful placing, raising gross proceeds of £1,015,000 via the issue
of 7,249,998 Ordinary Shares at a price of 14 pence per share.

In addition, on 16 September 2022 the Company announced the resignation of
Mark Freeman as a non-executive director together with the following board
appointments:

·      Trevor Ajanthan (Ajan) Reginald as Executive Director and Chief
Executive Officer;

·      Professor Sir Martin Evans as Executive Director and Group Chief
Scientific Officer; and

·      Dr Darrin Disley as Non-Executive Director.

Other than the above, there has been no significant change in either the
financial performance or the financial position of the Group since 30 June
2022.

17           Ultimate Controlling Party

As at 30 June 2022, there was no ultimate controlling party of the Company.

18           Nature of the Consolidated Condensed Interim Financial Statements

The Company Financial Information presented above does not constitute
statutory accounts for the period under review.

19           Approval of the Condensed Interim Financial Statements

The Condensed Interim Financial Statements were approved by the Board of
Directors on 22 September 2022.

 

 1  (#_ftnref1) Therapeutic Innovation & Regulatory Science (2022)
56:313-322 https://doi.org/10.1007/s43441-021-00364-y
(https://doi.org/10.1007/s43441-021-00364-y)

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