** Shares of biotech firm Replimune REPL.O rise 16.47% to $3.89
** U.S. President Donald Trump is planning to fire U.S. Food and Drug Administration Commissioner Marty Makary, the Wall Street Journal reports, citing people familiar with the matter
** Makary on Tuesday defended the regulator's decision to not approve REPL's drug, Tudriqev for advanced skin cancer
** Last month, the health regulator declined to approve the drug for the second time
** Including session's move, REPL down ~60% YTD
(Reporting by Kunal Das in Bengaluru)
((Kunal.Das2@thomsonreuters.com;))