REG - Sareum Holdings PLC - Update on SRA737

Sareum HoldingsAnnouncement

06/03/2023 07:00

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RNS Number : 9132R  Sareum Holdings PLC  06 March 2023

Sareum Holdings PLC

("Sareum" or the "Company")

Update on SRA737

Cambridge, UK, 6 March 2023 - Sareum Holdings plc (AIM: SAR), a biotechnology
company developing next generation kinase inhibitors for autoimmune disease
and cancer, today announces that Sierra Oncology, Inc. ("Sierra") (a
subsidiary of GSK plc) has completed the return of the Clinical Study Reports
and other associated documents and data related to SRA737 to Sareum's
co-development partner, the CRT Pioneer Fund LP ("CPF").

SRA737 is a clinical-stage oral, selective Checkpoint kinase 1 inhibitor that
targets cancer cell replication and DNA damage repair mechanisms. It was
discovered and initially developed by scientists at The Institute of Cancer
Research in collaboration with Sareum, with funding from Sareum and Cancer
Research UK.

CPF acquired
(http://www.sareum.com/news/press-releases-and-news/2013/sareum-enters-agreement-advance-chk1-programme/)
worldwide commercial rights to the programme in 2013 as part of a
co-development agreement with Sareum. SRA737 was licensed
(http://www.sareum.com/news/press-releases-and-news/2016/licence-agreement-chk1-inhibitor-cct245737/)
by CPF to Sierra in September 2016. Sierra progressed SRA737 through Phase 1/2
clinical development and, at the 2019 ASCO Annual meeting, reported
(http://www.sareum.com/news/press-releases-and-news/2019/positive-sra737-data-reported-asco/)
positive preliminary efficacy and safety data from two clinical trials
evaluating SRA737 as a monotherapy and in combination with chemotherapy. In
addition, preclinical data have been reported that indicate triple drug
combinations involving SRA737 may show great promise against hard-to-treat
cancers. Sierra has not progressed the asset beyond the Phase 1/2 clinical
trial.

Following the acquisition of Sierra by GSK in July 2022, primarily for
Sierra's momelotinib myelofibrosis asset, the rights to SRA737 were returned
to CPF in January 2023.

Sareum is evaluating potential further development opportunities for SRA737
with CPF and will provide further updates as appropriate.

Dr Tim Mitchell, CEO of Sareum, commented: "Our primary focus remains on
developing innovative TYK2/JAK1 inhibitors focused on autoimmune disease,
including our lead product SDC-1801. We look forward to evaluating the
potential development opportunities for SRA737 with CPF and will provide
further updates in due course."

- Ends -

 

For further information, please contact:

 Sareum Holdings plc

 Tim Mitchell, CEO                                   01223 497700

 Alex Harrison, Investor Relations                   ir@sareum.co.uk

 Strand Hanson Limited (Nominated Adviser)

 James Dance / James Bellman                         020 7409 3494

 Peel Hunt LLP (Joint Corporate Broker)

 James Steel / Oliver Duckworth                      020 7418 8900

 Hybridan LLP (Joint Corporate Broker)

 Claire Noyce                                        020 3764 2341

 Consilium Strategic Communications (Financial PR)

 Jessica Hodgson / Davide Salvi / Stella Lempidaki   0203 709 5700

 

About Sareum

Sareum is a specialist drug development company delivering targeted small
molecule therapeutics to improve the treatment of cancer and autoimmune
diseases. The Company aims to generate value through licensing its candidates
to international pharmaceutical and biotechnology companies at the preclinical
or early clinical trials stage.

Sareum is focused on advancing internal programmes focused on distinct dual
tyrosine kinase 2 (TYK2) / Janus kinase 1 (JAK1) inhibitors into clinical
development as potential new therapies for autoimmune diseases (with an
initial focus on psoriasis), respiratory symptoms arising from viral
infections and cancer immunotherapy. Sareum is also eligible to receive
certain milestone payments and future royalties on SRA737, a clinical-stage,
oral, selective Checkpoint kinase 1 (Chk1) inhibitor that targets cancer cell
replication and DNA damage repair mechanisms. SRA737 was licensed to Sierra
Oncology, which was acquired by GSK in June 2022.

Sareum Holdings plc is listed on the AIM market of the London Stock Exchange,
trading under the ticker SAR. For further information, please visit the
Company's website at www.sareum.com

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