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SYRE — Spyre Therapeutics News Story

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- Wall Street's main indexes gained on Wednesday, as a softer-than-anticipated inflation reading buoyed hopes that the Federal Reserve might not hike rates as soon as next month. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was up 0.08% at 51,389.59. The S&P 500 .SPX was up 0.59% at 7,716.14, and the Nasdaq Composite .IXIC was up 0.98% at 27,061.33.

The top three S&P 500 .PG.INX percentage gainers:

** Gen Digital Inc. GEN.OQ, up 6.4%

** Hewlett Packard Enterprise Company HPE.N, up 6.3%

** CBOE Global Markets, Inc. CBOE.Z, up 5.2%

The top three S&P 500 .PL.INX percentage losers:

** Moderna, Inc. MRNA.OQ, down 8.3%

** Jabil Inc. JBL.N, down 5.9%

** Constellation Energy Corp CEG.OQ, down 4.5%

The top three NYSE .PG.N percentage gainers:

** Generation Essentials Group TGE.N, up 69.9%

** Rogers Corporation ROG.N, up 17.3%

** SES AI Corporation SES.N, up 17.1%

The top three NYSE .PL.N percentage losers:

** Rafael Holdings Inc RFL.N, down 38.9%

** Trulieve Cannabis Corp ( Delaware ) TRLV.N, down 17.2%

** Glass House Brands Inc GLAS.N, down 15.2%

The top three Nasdaq .PG.O percentage gainers:

** NewGenIvf Group Ltd NIVF.OQ, up 138.6%

** Tenon Medical Inc TNON.OQ, up 49.8%

** Creative Media & Community Trust Corporation CMCT.OQ, up 31.8%

The top three Nasdaq .PL.O percentage losers:

** Liquidia Corporation LQDA.OQ, down 33.9%

** DarkIris Inc DKI.OQ, down 33.3%

** Oceanpal Inc SVRN.OQ, down 28.4%

** Boeing Co BA.N:
BUZZ - Rises after landing $20 billion US Navy fighter jet contract nL6N43I0B0

** Concentrix Corp CNXC.O:
BUZZ - Slides as $1.05 billion charge drives Q3 loss nL6N45M0IP

** GameStop Corp GME.N:
BUZZ - Rises as CEO buys another $10.5 million of stock nL6N45M0KW

** Pyxis Oncology Inc PYXS.O:
BUZZ - Drops on $110 mln stock-and-warrants deal nL6N45M0NZ

** Robinhood Markets Inc HOOD.O:
BUZZ - Gains as weekend stock trading expands 24-hour push nL6N45M0N8

** Lumentum Holdings Inc LITE.O:
BUZZ - Up; Bernstein initiates coverage with 'outperform' nL4N45M0PP

** Cal-Maine Foods Inc CALM.O:
BUZZ - Drops after co posts wider quarterly loss nL6N45M0O8

** Moderna Inc MRNA.O:
BUZZ - Slips after Citi downgrades to 'sell' nL6N45M0O9

** Conagra Brands Inc CAG.N:
BUZZ - Falls after maintaining annual forecast nL6N45M0UB

** FactSet Research Systems Inc FDS.N:
BUZZ - Slips as soft full year guidance overshadows Q4 revenue beat nL4N45M0VW

** Peoples Bancorp Inc PEBO.O:
BUZZ - Slips on all-stock Capital Bancorp merger deal nL6N45M0Q6

** Hewlett Packard Enterprise Company HPE.N:
BUZZ - Rises on $1.2 billion Vultr deal, guidance raise nL4N45M0Y9

** Mattel Inc MAT.O:
BUZZ - Slips after announcing CEO transition nL6N45M0SZ

** Elmet Group Co ELMT.O:
BUZZ - Rises after $36 million US defense contract nL6N45M0TR

** Celcuity Inc CELC.O:
BUZZ - Gains as breast cancer drug launches in US nL4N45M14I

** Synopsys Inc SNPS.O:
BUZZ - Up on over $1 billion chip design licensing deal with Amazon nL4N45M14Q

** Expedia Group Inc EXPE.O:
BUZZ - Truist trims Expedia PT, cites concerns over Meta's Muse AI agent nL4N45M0ZH

** Cboe Global Markets Inc CBOE.N:
BUZZ - Shares rise on plans for event-driven products plan nL6N45M0Y9

** Norwegian Cruise Line Holdings Ltd NCLH.N:
BUZZ - Climbs after raising Q3 expectations nL6N45M0SL

** Accelevation Holdings Corp ACCV.O:
BUZZ - Poised for Nasdaq debut after below-range IPO nL6N45M0W2

** The Hartford Insurance Group Inc HIG.N:
BUZZ - Announces CEO succession; shares slip nL4N45M195

** General Mills Inc GIS.N:
BUZZ - Slips on CEO succession plan nL6N45M0XY

** Spyre Therapeutics Inc SYRE.O:
BUZZ - Gains after Merck's drug succeeds in skin disease trial nL4N45M1CK

** Space Exploration Technologies Corp SPCX.O:
BUZZ - Macquarie maintains bullish view on SpaceX after AI agreements, Starship mission success nL4N45M18F

** Capricor Therapeutics Inc CAPR.O:
BUZZ - Rises after promising 24-month data on Duchenne drug nL4N45M1CU

** Grocery Outlet Holding Corp GO.O:
BUZZ - Rises after BofA lifts rating to 'buy' nL6N45M0Y5

Index RIC

Index name

Percent change %

.SPX

S&P 500

0.6

.SPLRCT

S&P 500 Information Technology

1.33

.SPLRCU

S&P 500 Utilities

-0.27

.SPLRCD

S&P 500 Consumer Discretionary

0.51

.SPLRCM

S&P 500 Materials

0.08

.SPLRCI

S&P 500 Industrials

-0.4

.SPLRCL

S&P 500 Communication Services (Sector)

1.41

.SPSY

S&P 500 Financials

-0.4

.SPLRCR

S&P 500 Real Estate

-0.71

.SPXHC

S&P 500 Health Care

-0.16

.SPLRCS

S&P 500 Consumer Staples

-0.65

.SPNY

S&P 500 Energy

0.76


(Rajarshi Roy and Pragyan Kalita)

((Rajarshi.Roy@thomsonreuters.com))

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