RCS - Synairgen plc - Company Announce Collaboration on UNIVERSAL Trial

SynairgenAnnouncement

05/09/2022 07:00

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RNS Number : 1893Y  Synairgen plc  05 September 2022

 

Synairgen plc

('Synairgen' or the 'Company')

Synairgen announces its collaboration on the UNIVERSAL trial, an observational
study of patients hospitalised due to a range of respiratory viruses

·      Led by the Clinical Trials Unit at the University of Southampton,
supported by Synairgen and funded by Janssen

·      Will explore the varied nature of acute respiratory viral
infections in hospitalised patients to inform the development of much-needed
broad spectrum antiviral drugs

Southampton, UK - 5 September  2022: Synairgen plc (LSE: SNG), the
respiratory company developing SNG001, an investigational formulation for
inhalation containing the broad-spectrum antiviral protein interferon beta,
today announces its collaboration on the UNIVERSAL trial, an observational
study being led by the Clinical Trials Unit of the University of Southampton
to explore and better understand the varied nature of acute respiratory viral
infection and recovery seen in patients admitted to hospital with respiratory
symptoms.

The Understanding Infection, Viral Exacerbation and Respiratory Symptoms at
Admission-Longitudinal (UNIVERSAL) trial seeks to develop a prospective
longitudinal clinical database of respiratory viral infections in hospitalised
patients to inform the development of potential antivirals to treat severe
viral lung infections caused by seasonal viruses and emerging viral threats.
Patients admitted to hospital due to a range of different respiratory viruses
will be sampled to determine the clinical and biological predictors of
progression of disease, recovery and length of hospital stay. As an
observational study, no treatments are being investigated.

The trial, which aims to recruit 1,000 patients, will be initiated at 10 sites
across the UK following enrolment of its first patient which occurred on 1
September 2022. Viral testing equipment already owned by Synairgen and nursing
staff at the Southampton clinical trial site are being provided by Synairgen,
funding for the trial is being provided by Janssen.

Richard Marsden, CEO of Synairgen, commented: "The COVID-19 pandemic
highlighted the important link between research and clinical care and its
impact on the timely development of much-needed antivirals for severe lung
viral infections caused by seasonal viruses and emerging respiratory viral
threats. Our collaboration on the UNIVERSAL trial will help provide a better
understanding of what could predict clinical outcomes in patients hospitalised
with respiratory symptoms due to infection with a range of respiratory
viruses. The UNIVERSAL trial will help to further inform the development
programme of SNG001, our investigational broad-spectrum antiviral."

Prof. Tom Wilkinson, Lead investigator of the UNIVERSAL trial and Professor of
Respiratory Medicine, University of Southampton, added: "As seen over the
course of the pandemic, individual response to respiratory virus infection is
variable from patient to patient, ranging from mild symptoms requiring no
treatment to severe illness requiring higher levels of care. This observation
highlights the need for a study like UNIVERSAL to better understand this
patient journey to enable for the development of effective therapeutics for
respiratory viral illness beyond COVID."

For further enquiries, please contact:

Synairgen plc

Brooke Clarke, Head of Communications

Media@synairgen.com (mailto:Media@synairgen.com)

Tel: + 44 (0) 23 8051 2800

 

finnCap (NOMAD and Joint Broker)

Geoff Nash, Charlie Beeson (Corporate Finance)

Alice Lane, Sunil de Silva (ECM)

Tel: + 44 (0) 20 7220 0500

 

Numis Securities Limited (Joint Broker)

James Black, Freddie Barnfield, Duncan Monteith

Tel: + 44 (0) 20 7260 1000

 

Consilium Strategic Communications (Financial Media and Investor Relations)

Mary-Jane Elliott, Namrata Taak, Lucy Featherstone

cscsynairgen@consilium-comms.com (mailto:cscsynairgen@consilium-comms.com)

Tel: +44 (0) 20 3709 5700

 

MKC STRATEGIES, LLC (US Media Relations)

Mary Conway

MConway@MKCStrategies.com (mailto:MConway@MKCStrategies.com)

Tel: +1 516-606-6545

 

Notes for Editors

About the UNIVERSAL trial

The Understanding Infection, Viral Exacerbation and Respiratory Symptoms at
Admission-Longitudinal (UNIVERSAL) trial is an observational study led by the
Clinical Trials Unit of the University of Southampton, supported by Synairgen
and funded by Janssen, to explore the varied nature of acute respiratory viral
infection and recovery seen in patients admitted to hospital with respiratory
symptoms. The trial will be initiated across 10 sites in the UK and seek to
enrol 1000 patients, where 1000 test positive for respiratory viral infection,
over a 12-month period. The primary endpoints of the trial are to determine
the incidence of different respiratory viruses in admitted, sampled patient
population during the winter season and, the clinical and biological
predictors of progression of disease, recovery and length of stay.

The trial will provide a better understanding of the natural history of acute
respiratory viral infection and recovery to facilitate improved clinical
management with the potential to identify options for intervention in those at
risk of more severe disease.

About Synairgen

Synairgen is a UK-based respiratory company focused on drug discovery,
development and commercialisation. The Company's primary focus is developing
SNG001 (inhaled interferon beta) for the treatment of severe viral lung
infections, including COVID-19, as potentially the first host-targeted,
broad-spectrum antiviral treatment delivered directly into the lungs. SNG001
has been granted Fast Track status from the US Food and Drug Administration
(FDA). Founded by University of Southampton Professors Sir Stephen Holgate,
Donna Davies and Ratko Djukanovic in 2003, Synairgen is quoted on AIM (LSE:
SNG). For more information about Synairgen, please see www.synairgen.com
(http://www.synairgen.com) .

 

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