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REG-Syncona Limited: Holding(s) in Company <Origin Href="QuoteRef">SYNCS.L</Origin>

For filings with the FCA include the annex                                                                                                                                                             
 For filings with issuer exclude the annex                                                                                                                                                              
                                                                                                                                                                                                        
 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES (i)                                                                                                                                                     
                                                                                                                                                                                                        
 1. Identity of the issuer or the underlying issuer                                                                                                             SYNCONA LIMITED                         
 of existing shares to which voting rights are                                                                                                                                                          
 attached: (ii)                                                                                                                                                                                         
 2 Reason for the notification (please tick the appropriate box or boxes):                                                                                                                              
 An acquisition or disposal of voting rights                                                                                                                                                            
 An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached                                        
 An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments                                                                                             
 An event changing the breakdown of voting rights                                                                                                                          X                            
 Other (please specify):                                                                                                                                                                                
 3. Full name of person(s) subject to the                                                                                  RATHBONE BROTHERS PLC                                                        
 notification obligation: (iii)                                                                                                                                                                         
 4. Full name of shareholder(s) (if different from 3.): (iv)                     RATHBONE BROTHERS PLC Rathbone Investment Management Ltd Rathbone Investment Management International Ltd              
 5. Date of the transaction and date on                                                                                          19/12/2016                                                             
 which the threshold is crossed or                                                                                                                                                                      
 reached: (v)                                                                                                                                                                                           
 6. Date on which issuer notified:                                                                                               20/12/2016                                                             
 7. Threshold(s) that is/are crossed or                                                                                           Under 5%                                                              
 reached: (vi, vii)                                                                                                                                                                                     
                                                                                                                                                                                                        

   

 8. Notified details:                                                                                                                                                                                                                        
 A: Voting rights attached to shares (viii, ix)                                                                                                                                                                                              
 Class/type of                             Situation previous                                                          Resulting situation after the triggering transaction                                                                  
 shares  if possible using the ISIN CODE   to the triggering                                                                                                                                                                                 
                                           transaction                                                                                                                                                                                       
                                                                 Number                                Number                                Number                      Number of voting                      % of 
                                                                 of                                    of                                    of shares                   rights                                votin 
                                                                 Shares                                Voting                                                                                                  g    
                                                                                                       Rights                                                                                                  right 
                                                                                                                                                                                                               s (x) 
                                                       Direct              Direct (xi)                 Indirect (xii)  Direct                              Indirect                    
               GG00B8P59C08                          22,583,470                            22,583,470                       22,583,470                   N/A              22,583,470                  N/A                       3.43%        
                                           
                                                                                                                                                                                                                                             
 B: Qualifying Financial Instruments                                                                                                                                                                                                         
 Resulting situation after the triggering transaction                                                                                                                                                                                        
 Type of financial                                               Expiration              Exercise/                                                         Number of voting                                    % of voting                   
 instrument                                                      date (xiii)             Conversion Period (xiv)                                           rights that may be                                  rights                        
                                                                                                                                                           acquired if the                                                                   
                                                                                                                                                           instrument is                                                                     
                                                                                                                                                           exercised/ converted.                                                             
                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                             
 C: Financial Instruments with similar economic effect to Qualifying Financial Instruments (xv, xvi)                                                                                                                                         
 Resulting situation after the triggering transaction                                                                                                                                                                                        
 Type of financial                                     Exercise price      Expiration date (xvii)      Exercise/                             Number of voting rights instrument refers to            % of voting rights (xix, xx)            
 instrument                                                                                            Conversion period (xviii)                                                                                                             
                                                                                                                                                                                                     Nominal                       Delta     
                                                                                                                       
                                                                                                                                                                                                                                             
 Total (A+B+C)                                                                                                                                                                                                                               
 Number of voting rights                                                                                                          Percentage of voting rights                                                                                
 22,583,470                                                                                                                       3.43                                                                                                       
                                                                                                                                                                                                                                             

   

 9. Chain of controlled undertakings through which the voting rights and/or the             
 financial instruments are effectively held, if applicable: (xxi)                           
 RATHBONE BROTHERS PLC*  Rathbone Investment Management Ltd 3.423%  Rathbone Investment Management International Ltd 0.007%    * Rathbone Brothers Plc is the holding company of the above 
                                                                                            
 Proxy Voting:                                                                              
 10. Name of the proxy holder:                                                              
 11. Number of voting rights proxy holder will cease                                        
 to hold:                                                                                   
 12. Date on which proxy holder will cease to hold                                          
 voting rights:                                                                             
                                                                                            
 13. Additional information:    Total voting rights used as a denominator:  658,387,407     
 14. Contact name:              Simon Walker – Compliance Department                        
 15. Contact telephone number:  0151 236 6666                                               
                                                                                            



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