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REG-Syncona Limited: Holding(s) in Company <Origin Href="QuoteRef">SYNCS.L</Origin>

For filings with the FCA include the annex                                                                                                                                        
 For filings with issuer exclude the annex                                                                                                                                         
                                                                                                                                                                                   
 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES (i)                                                                                                                                
                                                                                                                                                                                   
 1. Identity of the issuer or the underlying issuer                                                                                                     Syncona Ltd                
 of existing shares to which voting rights are                                                                                                                                     
 attached: (ii)                                                                                                                                                                    
 2 Reason for the notification (please tick the appropriate box or boxes):                                                                                                         
 An acquisition or disposal of voting rights                                                                                                                                  X    
 An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached                   
 An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments                                                                        
 An event changing the breakdown of voting rights                                                                                                                                  
 Other (please specify):           Type 1 disclosure as per the Transparency Directive II Regulation                                                                          X    
 3. Full name of person(s) subject to the                                                                            Schroders plc                                                 
 notification obligation: (iii)                                                                                                                                                    
 4. Full name of shareholder(s) (if different from 3.): (iv)                                                    Schroder & Co. Limited                                             
 5. Date of the transaction and date on                                                                                19.12.16                                                    
 which the threshold is crossed or                                                                                                                                                 
 reached: (v)                                                                                                                                                                      
 6. Date on which issuer notified:                                                                                     20.12.16                                                    
 7. Threshold(s) that is/are crossed or                                                                                Below 5%                                                    
 reached: (vi, vii)                                                                                                                                                                
                                                                                                                                                                                   

   

 8. Notified details:                                                                                                                                                                                                                          
 A: Voting rights attached to shares (viii, ix)                                                                                                                                                                                                
 Class/type of                             Situation previous                                     Resulting situation after the triggering transaction                                                                                         
 shares  if possible using the ISIN CODE   to the triggering                                                                                                                                                                                   
                                           transaction                                                                                                                                                                                         
                                                                Number                  Number                         Number                              Number of voting                                      % of 
                                                                of                      of                             of shares                           rights                                                votin 
                                                                Shares                  Voting                                                                                                                   g    
                                                                                        Rights                                                                                                                   right 
                                                                                                                                                                                                                 s (x) 
                                                                Direct                                                 Direct (xi)                         Indirect (xii)  Direct                                Indirect            
          Ordinary  GG00B8P59C08                   32,953,160                  32,953,160                   32,772,570                                                      32,772,570                                           4.978%        
                                                                                                                                                                                                                                               
 B: Qualifying Financial Instruments                                                                                                                                                                                                           
 Resulting situation after the triggering transaction                                                                                                                                                                                          
 Type of financial                                              Expiration              Exercise/                                                          Number of voting                                      % of voting                   
 instrument                                                     date (xiii)             Conversion Period (xiv)                                            rights that may be                                    rights                        
                                                                                                                                                           acquired if the                                                                     
                                                                                                                                                           instrument is                                                                       
                                                                                                                                                           exercised/ converted.                                                               
                                                                                                                                                                                                                                               
                                                                                                                                                                                                                                               
 C: Financial Instruments with similar economic effect to Qualifying Financial Instruments (xv, xvi)                                                                                                                                           
 Resulting situation after the triggering transaction                                                                                                                                                                                          
 Type of financial                                     Exercise price         Expiration date (xvii)        Exercise/                        Number of voting rights instrument refers to              % of voting rights (xix, xx)            
 instrument                                                                                                 Conversion period (xviii)                                                                                                          
                                                                                                                                                                                                       Nominal                       Delta     
                                                                                                  
                                                                                                                                                                                                                                               
 Total (A+B+C)                                                                                                                                                                                                                                 
 Number of voting rights                                                                                               Percentage of voting rights                                                                                             
                                                      32,772,570                                                                                                               4.978%                                                          
                                                                                                                                                                                                                                               

   

 9. Chain of controlled undertakings through which the voting rights and/or the                                                                                                                                                                                                                                                                                                                                                                                             
 financial instruments are effectively held, if applicable: (xxi)                                                                                                                                                                                                                                                                                                                                                                                                           
 Schroder & Co. Limited 32,772,570 4.978%                                                                                                                                                                                                                                                                                                                                                                                                                                   
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 Proxy Voting:                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 10. Name of the proxy holder:                                                                                                                                                                                                                                                                                                                                                                                                                                              
 11. Number of voting rights proxy holder will cease                                                                                                                                                                                                                                                                                                                                                                                                                        
 to hold:                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 12. Date on which proxy holder will cease to hold                                                                                                                                                                                                                                                                                                                                                                                                                          
 voting rights:                                                                                                                                                                                                                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 13. Additional information:    This notification is being made based on the legal entity position falling below 5%. Schroders plc’s position remains within disclosure thresholds as per the previous disclosure.The shares referred to in section 9 are held in portfolios managed by those firms on a discretionary basis for clients under investment management agreements. This disclosure has been calculated based on issue share capital amount 658,387,407.       
 14. Contact name:                                                                                                                                                                                                                             Chloe Talbot                                                                                                                                                                                                                 
 15. Contact telephone number:                                                                                                                                                                                                               +44 207 658 6000                                                                                                                                                                                                               
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            



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