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U.S. stock indexes fell sharply on Thursday, with the Dow on track for its
steepest single-day fall in three months, as the Federal Reserve's guidance for
protracted policy tightening quelled hopes of the rate-hike cycle ending anytime
soon.  .N 
    At 11:40 a.m. ET, the Dow Jones Industrial Average  .DJI  was down 2.24% at
33,204.39. The S&P 500  .SPX  was down 2.46% at 3,896.87 and the Nasdaq
Composite  .IXIC  was down 2.90% at 10,846.744.
 
 The top three S&P 500  .PG.INX  percentage gainers:
 ** Align Technology Inc  ALGN.OQ , up 6.1%
 ** Charles River Laboratories International Inc  CRL.N , up 5.1%
 ** Fortune Brands Home & Security Inc  FBIN.N , up 2.8%
 
 The top three S&P 500  .PL.INX  percentage losers:
 ** MasterBrand Inc  MBC.N , down 10%
 ** Generac Holdings Inc  GNRC.N , down 8.2%
 ** EPAM Systems Inc  EPAM.N , down 8.2%
 
 The top three Nasdaq  .PG.O  percentage gainers:
 ** Icosavax Inc  ICVX.O , up 43.3%
 ** Clearmind Medicine Inc  CMND.O , up 29.6%
 ** Kintara Therapeutics Inc  KTRA.O , up 26.1%
 
 The top three Nasdaq  .PL.O  percentage losers:
 ** Third Harmonic Bio Inc  THRD.O , down 77%
 ** Gorilla Technology Group Inc  GRRR.O , down 31.6%
 ** Miromatrix Medical Inc  MIRO.O , down 27.3%
 
 ** Core Scientific Inc  CORZ.O : up 41.2%
 BUZZ - Extends gains as B.Riley offers $72 mln to avoid bankruptcy  urn:newsml:reuters.com:*:nL4N3352I0
 ** Newmont Corp  NEM.N : down 2.1%
 ** Barrick Gold Corp  GOLD.N : down 3.0%
 ** Sibanye Stillwater Ltd  SBSW.N : down 4.2%
 ** AngloGold Ashanti Ltd  AU.N : down 4.3%
 BUZZ - Gold miners decline as dollar rises on hawkish Fed  urn:newsml:reuters.com:*:nL4N3352OW 
 ** Trade Desk Inc  TTD.O : down 6.5%
 BUZZ - Shares fall on Jefferies downgrade to 'hold'  urn:newsml:reuters.com:*:nL4N3352MW 
 ** Western Digital Corp  WDC.O : down 7.3%
 BUZZ - Falls 5% on report Goldman slaps 'sell' rating  urn:newsml:reuters.com:*:nL4N3352RZ 
 ** Cognizant Technology Solutions Corp  CTSH.O : down 3.4%
 BUZZ - JPM downgrades Cognizant to 'underweight' on macroeconomic woes
 urn:newsml:reuters.com:*:nL4N3352R2
 ** New Fortress Energy Inc  NFE.O : down 9.2%
 BUZZ -Falls on pricing secondary share offering  urn:newsml:reuters.com:*:nL1N3350VD 
 ** Reviva Pharmaceuticals Holdings Inc  RVPH.O : up 3.2%
 BUZZ - Rises on positive schizophrenia drug interaction trial data  urn:newsml:reuters.com:*:nL4N3352TA
 ** AbCellera Biologics Inc  ABCL.O : up 3.5%
 BUZZ - Up on partnership with AbbVie for antibody therapies  urn:newsml:reuters.com:*:nL4N3352UY 
 ** JetBlue Airways Corp  JBLU.O : down 3.3%
 BUZZ - Cowen downgrades JetBlue Airways as pending merger awaits approval
 urn:newsml:reuters.com:*:nL4N3352V6 
 ** Snap Inc  SNAP.N : down 8.4%
 BUZZ - Falls after Jefferies downgrades stock amid digital ads weakness
 urn:newsml:reuters.com:*:nL4N3352VL 
 ** Hexo Corp  HEXO.O : down 19.8%
 BUZZ - Falls on raising going concern doubts  urn:newsml:reuters.com:*:nL4N3352VY 
 ** AT&T Inc  T.N : down 1.8%
 BUZZ - Morgan Stanley downgrades AT&T on slow growth expectations in 2023
 urn:newsml:reuters.com:*:nL4N3352W0 
 ** Dow Inc  DOW.N : down 2.9%
 ** LyondellBasell Industries NV  LYB.N : down 2.8%
 ** Olin Corp  OLN.N : down 3.6%
 ** Westlake Corp  WLK.N : down 2.7%
 BUZZ - Weak demand for chemicals to persist through at least Q1 2023 - Credit
Suisse  urn:newsml:reuters.com:*:nL4N3352VU 
 ** EOG Resources Inc  EOG.N : down 1.6%
 BUZZ - PT cut by Truist Securities on rising costs  urn:newsml:reuters.com:*:nL4N3352UN 
 ** Third Harmonic Bio Inc  THRD.O : down 76.4% premarket
 BUZZ - Down on discontinuation of inflammation drug study  urn:newsml:reuters.com:*:nL4N3352X6 
 ** FedEx Corp  FDX.N : down 2.4%
 BUZZ - Baird lowers FedEx PT as weak demand pressures volume  urn:newsml:reuters.com:*:nL4N3352WS 
 ** Verizon Communications Inc  VZ.N : up 0.9%
 BUZZ - Rises after MS upgrades stock to 'overweight'  urn:newsml:reuters.com:*:nL4N3352Y9 
 ** Alight Inc  ALIT.N : down 10.2%
 BUZZ - Drops as block trade marketed  urn:newsml:reuters.com:*:nL1N33511O 
 ** Nikola Corp  NKLA.O : up 1.7%
 BUZZ - Gains on truck sales deal with Plug Power  urn:newsml:reuters.com:*:nL4N3352NX 
 ** Astria Therapeutics Inc  ATXS.O : up 14.5%
 BUZZ - Rises on early trial data of swelling disease drug  urn:newsml:reuters.com:*:nL4N33530H 
 ** Netflix Inc  NFLX.O : down 7.5%
 BUZZ - Falls after report says ad-supported plan off to a slow start
 urn:newsml:reuters.com:*:nL4N33532D 
 ** Trip.com Group Ltd  TCOM.O : up 0.9%
 BUZZ - Morgan Stanley raises Trip.com PT on revenue rebound  urn:newsml:reuters.com:*:nL4N335327 
    
 ** BioCryst Pharmaceuticals Inc  BCRX.O : down 1.8%
 BUZZ - Slips on discontinuing development of blood disorder drug  urn:newsml:reuters.com:*:nL4N33532S
 ** Soligenix Inc  SNGX.O : up 15.1%
 BUZZ - Seeks FDA nod for marketing its cancer therapy, shares rise  urn:newsml:reuters.com:*:nL4N335354
 ** CASI Pharmaceuticals Inc  CASI.O : up 6.4%
 BUZZ - Up on Chinese nod for cancer therapy application  urn:newsml:reuters.com:*:nL4N3352W6
 ** Roblox Corp  RBLX.N : down 16.5%
 BUZZ - Down after user metrics drop  urn:newsml:reuters.com:*:nL4N3353CB
 ** Nucor Corp  NUE.N : down 8.1%
 BUZZ - Sees Q4 earnings below estimates, shares slip  urn:newsml:reuters.com:*:nL4N33536V
 ** Kintara Therapeutics Inc  KTRA.O : up 26.1%
 BUZZ - Rises as FDA grants orphan drug tag to its brain cancer drug
 urn:newsml:reuters.com:*:nL4N33539H
 ** Mid America Apartment Communities Inc  MAA.N : down 2.4%
 BUZZ - UBS initiates coverage of Mid America Apartment at 'sell'  urn:newsml:reuters.com:*:nL4N33536L
 ** Intel Corp : down 3.3%    
 ** Advanced Micro Devices Inc   AMD.O : down 3.2%
 ** Nvidia Corp  NVDA.O : down 4.8%
 ** Marvel Technology Inc  MRVL.O : down 5.5%
 BUZZ - Semiconductor index past bottom, investors eye soft landing into 2023 -
Evercore  urn:newsml:reuters.com:*:nL4N3353F0
 ** Hecla Mining Co  HL.N : down 4.5%
 ** Coeur Mining Inc  CDE.N : down 5.1%
 BUZZ - Silver miners, ETFs fall as U.S. dollar firms on hawkish Fed
 urn:newsml:reuters.com:*:nL4N3352RB
 ** Alibaba.com Ltd  BABA.N : down 3.1%
 ** JD.com Inc  JD.O : down 2.9%
 ** Pinduoduo Inc  PDD.O : down 4.0%
 ** NetEase Inc  NTES.O : down 1.3%
 BUZZ - China ADRs fall as U.S. regulator gets full access to inspect Chinese
firms  urn:newsml:reuters.com:*:nL4N3353FU
 The 11 major S&P 500 sectors:
 
 Communication Services   .SPLRCL   down 3.40%
 Consumer Discretionary   .SPLRCD   down 2.30%
 Consumer Staples         .SPLRCS   down 2.06%
 Energy                   .SPNY     down 2.11%
 Financial                .SPSY     down 2.03%
 Health                   .SPXHC    down 1.62%
 Industrial               .SPLRCI   down 2.64%
 Information Technology   .SPLRCT   down 3.26%
 Materials                .SPLRCM   down 2.89%
 Real Estate              .SPLRCR   down 1.28%
 Utilities                .SPLRCU   down 1.38%
 (Compiled by Rajarshi Roy and Pratyush Thakur)
 ((Rajarshi.Roy@thomsonreuters.com; pratyush.thakur@thomsonreuters.com))

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