(Updates)
** U.S.-listed shares QURE.O of gene therapy developer
UniQure fall ~41% to more than five-year low of $10.51
** Stock among top pct losers across U.S. exchanges
** Netherlands-based company's gene therapy for Huntington's
disease reduced levels of key protein linked to the disease by
8.1% at lower dose vs 52.8% reduction reported by company last
year
** Huntington's disease is an inherited disorder which
results in the death of brain cells and is caused by a mutation
in the gene for a protein called huntingtin (HTT)
** Stifel analysts say mHTT data very confusing and
discordant with prior 1-year data
** In updated data from an early- to mid-stage trial, QURE
says the gene therapy helped improve motor score and other
measures
** UniQure's U.S.-listed shares down 14.3% YTD
(Reporting by Manas Mishra and Bhanvi Satija)
((Manas.Mishra@thomsonreuters.com;
www.twitter.com/Manaswrites15))