** U.S.-listed shares of UroGen Pharma Ltd URGN.O fall
2.8% to $9.30 in premarket trading
** Brokerage Jefferies downgrades the Israel-based biotech
co to "hold" from "buy" on commercial underperformance and cuts
PT to $10 from $35
** Jefferies increases stock's discount rate to 14% from 11%
** Also reduces sales projections of co's cancer drug,
Jelmyto, and experimental urinary bladder cancer treatment,
Vesigel, by ~30% because of slower uptake
** Marginally increases 2023-2025 cost of goods sold (COGS)
to 11% from 10% and selling, general and administrative expenses
(SG&A) to 5% in 2025 on account of the Vesigel launch
** 4 of 6 brokerages covering the stock rate it "buy" or
higher, and 2 recommend "hold"; median PT is $23 - Refinitiv
data
** URGN stock feel 6.7% in 2022
(Reporting by Pratik Jain in Bengaluru)
((Pratik.Jain@thomsonreuters.com;))