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VRTX Vertex Pharmaceuticals News Story

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U.S. STOCKS ON THE MOVE-Marriott International, Coty, Carlyle Group

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Wall Street's main indexes were almost flat on Tuesday as gains
in megacaps such as Coca-Cola and Apple offset losses in some
growth stocks, while investors parsed Federal Reserve Chair
Jerome Powell's latest comments.  .N 
    
    At 13:33 EST, the Dow Jones Industrial Average  .DJI  was up
0.10% at 44,513.25. The S&P 500  .SPX  was down 0.06% at
6,062.78 and the Nasdaq Composite  .IXIC  was down 0.32% at
19,652.35.
    
 The top three S&P 500  .PG.INX  percentage gainers:
 ** Intel Corp  INTC.O , up 7.3%
 ** Dupont De Nemours Inc  DD.N , up 7.1%
 ** Ecolab Inc  ECL.N , up 6.5%
    
 The top three S&P 500  .PL.INX  percentage losers:
 ** Fidelity National Information Services  FIS.N , down 12.8%
 ** Super Micro Computer Inc  SMCI.O , down 8.6%
 ** Humana Inc  HUM.N , down 7.6%
    
 The top three NYSE  .PG.N  percentage gainers:
    
 ** SelectQuote Inc  SLQT.N , up 28.8%
 ** BP Prudhoe Bay Royalty Trust  BPT.N , up 19.5%
 ** FiscalNote Holdings Inc  NOTE.N , up 18.1%
    
 The top three NYSE  .PL.N  percentage losers:
 ** Paysafe Ltd  PSFE.N , down 17.5%
 ** Youdao Inc  DAO.N , down 16.7%
 ** Fidelity National Information Services  FIS.N , down 12.8%
    
 The top three Nasdaq  .PG.O  percentage gainers:
 ** Firefly Neuroscience Inc  AIFF.O , up 181.0%
 ** Omega Therapeutics Inc  OMGA.O , up 101.1%
 ** Blue Hat Interactive Entertainment Technology  BHAT.O , up
51.0%
    
 The top three Nasdaq  .PL.O  percentage losers:
 ** Fitell Corp  FTEL.O , down 53.0%
 ** Fluence Energy Inc  FLNC.O , down 48.9%
 ** Columbus McKinnon Corp  CMCO.O , down 42.5%
    
 ** Phillips 66  PSX.N :
 BUZZ - Rises after Elliott builds over $2.5 billion stake
 urn:newsml:reuters.com:*:nL4N3P21BH
    
 ** Coca-Cola Co  KO.N :
 BUZZ - Up after quarterly results beat estimates on strong
demand  urn:newsml:reuters.com:*:nL4N3P21C7
    
 ** United States Steel Corp  X.N :
 ** Nucor Corp  NUE.N :
 ** Steel Dynamics Inc  STLD.O :
 ** Century Aluminum Co  CENX.O :
 BUZZ - US steel, aluminum cos rise after Trump raises tariffs
on steel, aluminum imports  urn:newsml:reuters.com:*:nL4N3P2175
    
 ** Lipella Pharmaceuticals Inc  LIPO.O :
 BUZZ - Jumps after inflammatory disease drug found safe in
study   urn:newsml:reuters.com:*:nL4N3P20OK
    
 ** Hawaiian Electric Industries Inc  HE.N :
 BUZZ - Up after court rules against insurers in Maui wildfire
settlement   urn:newsml:reuters.com:*:nL4N3P20O9
    
 ** Leidos Holdings Inc  LDOS.N :
 BUZZ - Rises after upbeat fourth-quarter results   urn:newsml:reuters.com:*:nL4N3P20RT
    
 ** HubSpot Inc  HUBS.N :
 BUZZ - J.P. Morgan raises HubSpot PT on positive executive
comments, AI tailwinds   urn:newsml:reuters.com:*:nL4N3P20R5
    
 ** Albemarle Corp   ALB.N :
 BUZZ - Citigroup cuts Albemarle PT on lower lithium price
estimates   urn:newsml:reuters.com:*:nL4N3P20SC
    
 ** Playa Hotels & Resorts Inc  PLYA.O :
 BUZZ - Deutsche Bank downgrades Playa following Hyatt
acquisition   urn:newsml:reuters.com:*:nL4N3P20UZ
    
 ** Hess Midstream LP  HESM.N :
 BUZZ - Down as BlackRock's GIP chops stake in upsized secondary
offering   urn:newsml:reuters.com:*:nL6N3P20EY
    
 ** Humana Inc  HUM.N :
 BUZZ - Rises as it sees Q1 medical cost ratio better than
expected   urn:newsml:reuters.com:*:nL4N3P20QS
    
 ** Marriott International Inc  MAR.O :
 BUZZ - Slips after lower-than-expected annual profit forecast
  urn:newsml:reuters.com:*:nL4N3P20W5
    
 ** Fidelity National Information Services Inc  FIS.N :
 BUZZ - Slides after downbeat Q1 forecast   urn:newsml:reuters.com:*:nL4N3P20VU
    
 ** S&P Global Inc  SPGI.N :
 BUZZ -  Rises on better-than-expected forecast, share buyback
 urn:newsml:reuters.com:*:nL4N3P20WJ
    
 ** Charles Schwab Corp  SCHW.N :
 BUZZ - Up as Canada's TD Bank exits in $13.1 bln secondary
stock offering, buyback   urn:newsml:reuters.com:*:nL6N3P20FR
    
 ** Crinetics Pharmaceuticals Inc  CRNX.O :
 BUZZ - Gains after TD Cowen starts with 'buy' on optimism for
lead drugs   urn:newsml:reuters.com:*:nL4N3P20XJ
    
 ** WK Kellogg Co  KLG.N :
 BUZZ - Rises after beating quarterly profit estimates
 urn:newsml:reuters.com:*:nL4N3P219Y
    
 ** Hyperfine Inc   HYPR.O :
 BUZZ -  Falls after pricing stock offering   urn:newsml:reuters.com:*:nL4N3P20Y5
    
 ** Sera Prognostics Inc  SERA.O :
 BUZZ - Tumbles on $50 mln stock offering  urn:newsml:reuters.com:*:nL6N3P20GZ
    
 ** Carlyle Group Inc  CG.O :
 BUZZ - Falls on Q4 profit miss  urn:newsml:reuters.com:*:nL4N3P213U
    
 ** Biohaven Ltd  BHVN.N :
 BUZZ - Rises as FDA grants priority review status for brain
disorder drug  urn:newsml:reuters.com:*:nL4N3P210S
    
 ** Ecolab Inc  ECL.N :
 BUZZ - Rises after upbeat 2025 profit forecast, Q4 earnings
beat  urn:newsml:reuters.com:*:nL4N3P210R
    
 ** Firefly Neuroscience Inc  AIFF.O :
 BUZZ - Rises on acceptance into Nvidia Connect program
 urn:newsml:reuters.com:*:nL4N3P216N
    
 ** Newmont Corp  NEM.N : 
 ** Gold Fields Ltd  GFI.N : 
 ** Harmony Gold Mining Co Ltd  HMY.N :
 ** Agnico Eagle Mines  AEM.N : 
 BUZZ - Gold miners fall as bullion prices edge lower
 urn:newsml:reuters.com:*:nL4N3P218B
    
 ** Arch Capital Group Ltd  ACGL.O :
 BUZZ - Falls after Q4 profit drop  urn:newsml:reuters.com:*:nL4N3P218N
    
 ** Fluence Energy Inc  FLNC.O :
 BUZZ - Plunges on weak results, grim outlook, analyst
downgrades  urn:newsml:reuters.com:*:nL6N3P20KP
    
 ** Inspire Medical Systems Inc  INSP.N :
 BUZZ - Falls on slower-than-expected sleep apnea device launch
 urn:newsml:reuters.com:*:nL4N3P217I
    
 ** Exxon Mobil Corp  XOM.N :
 ** Chevron Corp  CVX.N :
 ** Devon Energy Corp  DVN.N :
 ** Diamondback Energy Inc  FANG.O : 
 BUZZ - US energy firms rise on supply worries after Trump's
tariffs  urn:newsml:reuters.com:*:nL4N3P2194
    
 ** Enphase Energy Inc  ENPH.O :
 BUZZ - Rises after launching expanded IQ Batteries for
California  urn:newsml:reuters.com:*:nL4N3P217V

 ** Cincinnati Financial Corp  CINF.O :
 BUZZ - Rises on higher Q4 operating profit  urn:newsml:reuters.com:*:nL4N3P21AM
    
 ** Coty Inc  COTY.N :
 BUZZ - Falls on trimming annual profit forecast, Q2 revenue
drop  urn:newsml:reuters.com:*:nL4N3P21D1
    
 ** DuPont de Nemours Inc :
 BUZZ - Rises after 2025 profit forecast tops expectations
 urn:newsml:reuters.com:*:nL4N3P21DL
    
 ** IN8BIO Inc  INAB.O :
 BUZZ - Rises on early-stage data from cancer therapy
 urn:newsml:reuters.com:*:nL4N3P2198
    
 ** Pagaya Technologies Inc  PGY.O :
 BUZZ - Slides after Iceberg Research discloses short
position urn:newsml:reuters.com:*:nL4N3P21HL
    
 ** CoreCivic Inc  CXW.N :
 BUZZ - Slides after 2025 EPS forecast misses expectations
 urn:newsml:reuters.com:*:nL6N3P20TI
    
 ** Vertex Pharmaceuticals Inc  VRTX.O :
 BUZZ - Falls after Q4 profit, sales of gene therapy disappoint
 urn:newsml:reuters.com:*:nL4N3P21CW
    
 ** Schlumberger NV  SLB.N :
 BUZZ - Rises on plan to cut jobs, reorganize company
 urn:newsml:reuters.com:*:nL4N3P21FP
    
 ** Lattice Semiconductor Corp  LSCC.O :
 BUZZ - Gains after Q4 results signal stability  urn:newsml:reuters.com:*:nL1N3P20W6
    
 ** Bank of NT Butterfield & Son Ltd  NTB.N :
BUZZ - Climbs after Q4 profit beats expectations  urn:newsml:reuters.com:*:nL4N3P21IC

 Index RIC  Index name                      Percent change %
  .SPX      S&P 500                         -0.06 
  .SPLRCT   S&P 500 Information Technology               0.34
  .SPLRCU   S&P 500 Utilities                           -0.25
  .SPLRCD   S&P 500 Consumer Discretionary              -1.36
  .SPLRCM   S&P 500 Materials                            0.44
  .SPLRCI   S&P 500 Industrials                         -0.28
  .SPLRCL   S&P 500 Communication Services              -0.24
            (Sector)                        
  .SPSY     S&P 500 Financials                          -0.01
  .SPLRCR   S&P 500 Real Estate                          0.15
  .SPXHC    S&P 500 Health Care                         -0.34
  .SPLRCS   S&P 500 Consumer Staples                     0.47
  .SPNY     S&P 500 Energy                               1.24
 
 (Reporting by Rajarshi Roy and Ateev Bhandari in Bengaluru)
 ((Ateev.Bhandari@thomsonreuters.com;))

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