** Shares of Vertex Pharmaceuticals VRTX.O fall 1.1% to $460.07 in after-market trading
** Co reports Q4 adj. profit of $5.03 per share, lower than estimates of $5.07 per share, as per LSEG data
** Forecasts 2026 revenue to be in the range of $12.95 billion to $13.1 billion, the midpoint of which is in line with analysts' estimates of $13.02 billion
** Reports Q4 revenue of $3.19 billion, compared with analysts' estimates of $3.18 billion
** VRTX was up 12.6% in 2025
(Reporting by Sneha S K)
((Sneha.SK@thomsonreuters.com))